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ALPI recombinant protein :: Intestinal-type alkaline phosphatase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1265148 (PROMOTIONAL PRICING: 10% OFF web price. Discount is not applicable for bulk pricing such as 5x96T or 10x96T. Discount will be applied after order has been placed)
SDS-PAGE
Unit / Price
0.01 mg  /  $150 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Intestinal-type alkaline phosphatase (ALPI), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Intestinal-type alkaline phosphatase

 Product Gene Name   

ALPI recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1265148 COA    COA PDF
 Sequence Positions    26-500. Partial.
 Sequence    ENPAFWNRQA AEALDAAKKL QPIQKVAKNL ILFLGDGLGV PTVTATRILK GQKNGKLGPE TPLAMDRFPY LALSKTYNVD RQVPDSAATA TAYLCGVKAN FQTIGLSAAA RFNQCNTTRG NEVISVMNRA KQAGKSVGVV TTTRVQHASP AGTYAHTVNR NWYSDADMPA SARQEGCQDI ATQLISNMDI DVILGGGRKY MFPMGTPDPE YPADASQNGI RLDGKNLVQE WLAKHQGAWY VWNRTELMQA SLDQSVTHLM GLFEPGDTKY EI HRDPTL DPSLMEMTEA ALRLLSRNPR GFYLFVEGGR IDHGHHEGVA YQALTEAVMF DDAIERAGQL TSEEDTLTLV TADHSHVFSF GGYTLRGSSI FGLAPSKAQD SKAYTSILYG NGPGYVFNSG VRPDVNESES GSPDYQQQAA VPLSSETHGG EDVAVFARGP QAHLVHGVQE QSFVAHVMAF AACLEPYTAC DLAPPAC
 OMIM    171740
 3D Structure    ModBase 3D Structure for P09923
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ALPI recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for ALPI recombinant protein    Signal Transduction
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 SDS-PAGE of ALPI recombinant protein    ALPI recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for ALPI. It may not necessarily be applicable to this product.
 NCBI GI #    157266292
 NCBI GeneID    248
 NCBI Accession #    NP_001622.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001631.4 [Other Products]
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 UniProt Primary Accession #    P09923 [Other Products]
 UniProt Secondary Accession #    Q53S80; Q9UBV5; Q9UCL2; B2R7Y4 [Other Products]
 UniProt Related Accession #    P09923 [Other Products]
 Molecular Weight    55.6kD
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 NCBI Official Full Name    intestinal-type alkaline phosphatase
 NCBI Official Synonym Full Names    alkaline phosphatase, intestinal
 NCBI Official Symbol    ALPI [Similar Products]
 NCBI Official Synonym Symbols   
IAP
[Similar Products]
 NCBI Protein Information    intestinal-type alkaline phosphatase
 UniProt Protein Name    Intestinal-type alkaline phosphatase
 Protein Family    Intestinal-type alkaline phosphatase
 UniProt Gene Name    ALPI [Similar Products]
 UniProt Synonym Gene Names    IAP; Intestinal alkaline phosphatase [Similar Products]
 UniProt Entry Name    PPBI_HUMAN
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 NCBI Summary for ALPI    There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]
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 UniProt Comments for ALPI    ALPI: intestinal alkaline phosphatase is one of four related alkaline phosphatases. The exact physiological function of alkaline phosphatases is not known. This protein is a GPI-anchored membrane bound glycosylated enzyme that is localized to fetal and adult intestines.

Protein type: Phosphatase; Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.1.3.1; Motility/polarity/chemotaxis; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: alkaline phosphatase activity; magnesium ion binding; protease binding; protein binding; zinc ion binding

Biological Process: dephosphorylation
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Product References and Citations for ALPI recombinant protein

   Cloning and sequencing of human intestinal alkaline phosphatase cDNA.Berger J., Garattini E., Hua J.-C., Udenfriend S.Proc. Natl. Acad. Sci. U.S.A. 84:695-698(1987) Nucleotide and amino acid sequences of human intestinal alkaline phosphatase close homology to placental alkaline phosphatase.Henthorn P.S., Raducha M., Edwards Y.H., Weiss M.J., Slaughter C., Lafferty M.A., Harris H.Proc. Natl. Acad. Sci. U.S.A. 84:1234-1238(1987) Sequence and characterization of the human intestinal alkaline phosphatase gene.Henthorn P.S., Raducha M., Kadesch T., Weiss M.J., Harris H.J. Biol. Chem. 263:12011-12019(1988) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) Generation and annotation of the DNA sequences of human chromosomes 2 and 4.Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.Nature 434:724-731(2005)
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 Research Articles on ALPI    1. Data indicate that histone deacetylase inhibitors (HDACi) induce intestinal alkaline phosphatase (ALPi) in a subset of colon cancer cell lines in a Kruppel-like factor 5 (KLF5)-dependent manner.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ALPI recombinant proteinPathways associated with ALPI recombinant protein
 Reference Product  PubMed Publications
 INHA recombinant protein  >2 publications with ALPI and INHA
 CHRND recombinant protein  >1 publications with ALPI and CHRND
 Products by Pathway  Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
Diseases associated with ALPI recombinant proteinOrgans/Tissues associated with ALPI recombinant protein
 Disease Name  Pubmed Publications
 Anemia Antibodies  >10 publications with ALPI and Anemia
 Cardiovascular Diseases Antibodies  >10 publications with ALPI and Cardiovascular Diseases
 Kidney Diseases Antibodies  >9 publications with ALPI and Kidney Diseases
 Chromosome Aberrations Antibodies  >9 publications with ALPI and Chromosome Aberrations
 Inflammation Antibodies  >9 publications with ALPI and Inflammation
 Diabetes Mellitus Antibodies  >6 publications with ALPI and Diabetes Mellitus
 Colitis Antibodies  >6 publications with ALPI and Colitis
 Colonic Neoplasms Antibodies  >5 publications with ALPI and Colonic Neoplasms
 Necrosis Antibodies  >5 publications with ALPI and Necrosis
 Edema Antibodies  >4 publications with ALPI and Edema
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >49 publications with ALPI and Intestine
 Heart Antibodies  >12 publications with ALPI and Heart
 Placenta Antibodies  >3 publications with ALPI and Placenta
 Amniotic Fluid Antibodies  >2 publications with ALPI and Amniotic Fluid
 Uterus Antibodies  >1 publications with ALPI and Uterus
 Esophagus Antibodies  >1 publications with ALPI and Esophagus
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