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IVL recombinant protein :: Involucrin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS306399 IVL recombinant protein
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Involucrin (IVL), Recombinant Protein

 Also Known As   

Recombinant Human Involucrin Protein

 Product Gene Name   

IVL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147360
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 Characterization    On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 41kDa (including GST).
 Source    Recombinant protein encoding human involucrin aa 420-578 expressed in E Coli.
 Domain    aa 420-578
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 Preparation and Storage    Store at -20 degree to -80 degree C. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
 Other Notes    Small volumes of IVL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for IVL. It may not necessarily be applicable to this product.
 NCBI GI #    44890059
 NCBI GeneID    3713
 NCBI Accession #    NP_005538.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005547.2 [Other Products]
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 UniProt Secondary Accession #    Q5T7P4 [Other Products]
 UniProt Related Accession #    P07476 [Other Products]
 Molecular Weight    68,479 Da [Similar Products]
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 NCBI Official Full Name    involucrin
 NCBI Official Synonym Full Names    involucrin
 NCBI Official Symbol    IVL [Similar Products]
 NCBI Protein Information    involucrin
 UniProt Protein Name    Involucrin
 Protein Family    Involucrin
 UniProt Gene Name    IVL [Similar Products]
 UniProt Entry Name    INVO_HUMAN
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 NCBI Summary for IVL    Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IVL    IVL: Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Belongs to the involucrin family.

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; cornified envelope

Molecular Function: protein binding, bridging; structural molecule activity

Biological Process: keratinocyte differentiation; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; keratinization; peptide cross-linking; response to UV-B
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 Research Articles on IVL    1. Together, these results suggest that GR modulates involucrin expression of keratinocytes by regulating the intracellular signaling network in a ligand-independent manner.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IVL recombinant proteinPathways associated with IVL recombinant protein
 Reference Product  PubMed Publications
 LOR recombinant protein  >5 publications with IVL and LOR
 SPRR3 recombinant protein  >2 publications with IVL and SPRR3
 JUNB recombinant protein  >2 publications with IVL and JUNB
 KRT1 recombinant protein  >1 publications with IVL and KRT1
 Products by Pathway  Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway antibodies  Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway Diagram
Diseases associated with IVL recombinant proteinOrgans/Tissues associated with IVL recombinant protein
 Disease Name  Pubmed Publications
 Skin Neoplasms Antibodies  >46 publications with IVL and Skin Neoplasms
 Leiomyoma Antibodies  >43 publications with IVL and Leiomyoma
 Brain Diseases Antibodies  >38 publications with IVL and Brain Diseases
 Lung Neoplasms Antibodies  >27 publications with IVL and Lung Neoplasms
 Lung Diseases Antibodies  >21 publications with IVL and Lung Diseases
 Heart Diseases Antibodies  >18 publications with IVL and Heart Diseases
 Liver Neoplasms Antibodies  >18 publications with IVL and Liver Neoplasms
 Neoplasm Invasiveness Antibodies  >16 publications with IVL and Neoplasm Invasiveness
 Pain Antibodies  >13 publications with IVL and Pain
 Anemia Antibodies  >13 publications with IVL and Anemia
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >79 publications with IVL and Skin
 Brain Antibodies  >62 publications with IVL and Brain
 Muscle Antibodies  >45 publications with IVL and Muscle
 Lung Antibodies  >36 publications with IVL and Lung
 Mouth Antibodies  >4 publications with IVL and Mouth
 Esophagus Antibodies  >3 publications with IVL and Esophagus
 Prostate Antibodies  >3 publications with IVL and Prostate
 Bladder Antibodies  >2 publications with IVL and Bladder
 Larynx Antibodies  >2 publications with IVL and Larynx
 Mammary Gland Antibodies  >1 publications with IVL and Mammary Gland
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