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Kcnj2 recombinant protein :: Inward rectifier potassium channel 2 (KCNJ2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS960204 Kcnj2 recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Inward rectifier potassium channel 2 (KCNJ2), Recombinant Protein

 Also Known As   

Recombinant Guinea pig Inward rectifier potassium channel 2 (KCNJ2)

 Product Synonym Names    Recombinant Inward rectifier potassium channel 2 (KCNJ2); Inward rectifier potassium channel 2; Cardiac inward rectifier potassium channel Inward rectifier K(+) channel Kir2.1; IRK-1 Potassium channel, inwardly rectifying subfamily J member 2
 Product Gene Name   

Kcnj2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    KCNJ2; IRK1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-427
 Sequence    MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK DGHCNVQFIN VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG CVFWLIALLH GDLDASKESK ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV TDECPIAVFM VVFQSIVGCI IDAFIIGAVM AKMAKPKKRN ETLVFSHNAV IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG EYIPLDQIDI NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDIDNA DFEIVVILEG MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKHYYKVD YSRFHKTYEV PNTPLCSARD LAEKKYILSN ANSFCYENEV ALTSKEEDDS ENGVPESTST DTPPDIDLHN QASVPLEPRP LRRESEI
 Chromosome Location    chromosome: Un
 3D Structure    ModBase 3D Structure for P52185
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Cavia porcellus (Guinea pig)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Kcnj2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Kcnj2. It may not necessarily be applicable to this product.
 NCBI GI #    290543565
 NCBI GeneID    100135566
 NCBI Accession #    NP_001166446.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001172975.1 [Other Products]
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 UniProt Primary Accession #    P52185 [Other Products]
 UniProt Related Accession #    P52185 [Other Products]
 Molecular Weight    48,318 Da [Similar Products]
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 NCBI Official Full Name    inward rectifier potassium channel 2
 NCBI Official Symbol    Kcnj2 [Similar Products]
 NCBI Official Synonym Symbols   
IRK1; IRK-1
[Similar Products]
 NCBI Protein Information    inward rectifier potassium channel 2; inward rectifier K(+) channel Kir2.1; inward rectifier potassium channel Kir2.1; cardiac inward rectifier potassium channel; inwardly-rectifying potassium channel Kir2.1; potassium channel, inwardly rectifying subfamily J member 2
 UniProt Protein Name    Inward rectifier potassium channel 2
 UniProt Synonym Protein Names   
Cardiac inward rectifier potassium channel; Inward rectifier K(+) channel Kir2.1; IRK-1; Potassium channel, inwardly rectifying subfamily J member 2
 Protein Family    Inward rectifier potassium channel
 UniProt Gene Name    KCNJ2 [Similar Products]
 UniProt Synonym Gene Names    IRK1; IRK-1 [Similar Products]
 UniProt Entry Name    IRK2_CAVPO
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 UniProt Comments for Kcnj2    Function: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked by external barium or cesium.

Subunit structure: Homomultimeric and heteromultimeric association with Kir2.3, resulting in an enhanced G-protein-induced current. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily. [View classification]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with Kcnj2 recombinant protein
 Disease Name  Pubmed Publications
 Arrhythmias, Cardiac Antibodies  >117 publications with Kcnj2 and Arrhythmias, Cardiac
 Cardiovascular Diseases Antibodies  >109 publications with Kcnj2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >108 publications with Kcnj2 and Heart Diseases
 Long QT Syndrome Antibodies  >75 publications with Kcnj2 and Long QT Syndrome
 Andersen Syndrome Antibodies  >65 publications with Kcnj2 and Andersen Syndrome
 Tachycardia, Ventricular Antibodies  >32 publications with Kcnj2 and Tachycardia, Ventricular
 Muscular Diseases Antibodies  >20 publications with Kcnj2 and Muscular Diseases
 Syncope Antibodies  >15 publications with Kcnj2 and Syncope
 Ventricular Fibrillation Antibodies  >14 publications with Kcnj2 and Ventricular Fibrillation
 SHORT QT SYNDROME 3 Antibodies  >12 publications with Kcnj2 and SHORT QT SYNDROME 3
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