View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List jak2b active protein :: JAK2, N-terminal GST tag Active Protein Catalog # MBS637772 Unit / Price 0.01 mg / $1,050 +1 FREE 8GB USB 5x0.01 mg / $4,470 +5 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name JAK2, N-terminal GST tag (jak2b), Active Protein Full Product Name JAK2, Recombinant, Human, N-terminal GST tag (Janus Kinase 2) Product Gene Name jak2b active protein[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Chromosome Location Chromosome: 5; NC_007116.5 (69030569..69106033). Location: chromosome: 5 Species Reactivity Human Purity/Purification 80% by SDS-PAGE Form/Format 25 mM Tris-HCl, pH 8.0, 100 mM sodium chloride, 0.05% Tween-20, 50% glycerol, 10 mM reduced glutathione, and 3mM DTT. Specific Activity 4 U/ug. One unit is defined as the amount of enzyme that will incorporate 1 nmol phosphate to the tyrosine substrate per minute at pH 7.4 and 30 degree C Assay Buffer 50 mM HEPES, pH 7.4, 3 mM MgCl2, 3 mM MnCl2, 1 mM DTT, 3uM Na orthovanadate, 0.5 mM ATP, 30 ug/ml Poly (Glu:Tyr)4:1 substrate, and 0.04ug recombinant JAK2 Preparation and Storage -70 degree CStability: >6 months at -80 degree C Active Protein Note Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product. Other Notes Small volumes of jak2b active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for jak2b active protein The Janus (JAK) family of cytoplasmic tyrosine kinases has been implicated in signal transduction induced by cytokines and growth factors, physically associated with ligand-bound receptors. This association that results in tyrosine phosphorylation and activation. JAK1 is approximately 130kD and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among JAK family members. Family members such as JAK1, JAK2, and TYK2 are ubiquitous, whereas JAK3 is predominantly expressed in T lymphocytes. Studies with mutant cells that do not express JAK1, JAK2, or TYK2 show that their activation is essential for cellular signaling. JAK family kinases may either phosphorylate each other or be phosphorylated by a yet undescribed tyrosine kinase. Different cytokines can activate via phosphorylation distinct JAK family members. In some cells, the membrane-associated gp130 protein has been implicated in the induction of JAK family phosphorylation, although gp130 itself has no known activity.Human Jak2 (GenBank Accession No. NM_004972), (a.a. 808-end) with N-terminal His tagMW 42.5kD, expressed in an Baculovirus infected Sf9 cell expression system. Product Categories/Family for jak2b active protein Molecular Biology; MB-Receptor Tyrosine Kinases Application Notes for jak2b active protein useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. TOP NCBI/Uniprot data below describe general gene information for jak2b. It may not necessarily be applicable to this product. NCBI GI # 226237500 NCBI GeneID 30298 NCBI Accession # BAH47262.1 [Other Products] Molecular Weight 42.5kD[Similar Products] TOP NCBI Official Full Name jak2 NCBI Official Synonym Full Names Janus kinase 2b NCBI Official Symbol jak2b [Similar Products] NCBI Official Synonym Symbols jak2; JAK2bCA [Similar Products] NCBI Protein Information tyrosine-protein kinase JAK2; PTK JAK2b; Jak2b kinase; protein tyrosine kinase JAK2b TOP Research Articles on jak2b 1. Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma signal. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Pathways associated with jak2b active protein Products by Pathway Pathway Diagram Adipocytokine Signaling Pathway antibodies Adipocytokine Signaling Pathway Diagram Adipocytokine Signaling Pathway antibodies Adipocytokine Signaling Pathway Diagram Cytokine Signaling In Immune System Pathway antibodies Cytokine Signaling In Immune System Pathway Diagram Delta-Notch Signaling Pathway antibodies Delta-Notch Signaling Pathway Diagram EGFR1 Signaling Pathway antibodies EGFR1 Signaling Pathway Diagram EPO Receptor Signaling Pathway antibodies EPO Receptor Signaling Pathway Diagram Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram Growth Hormone Receptor Signaling Pathway antibodies Growth Hormone Receptor Signaling Pathway Diagram Hemostasis Pathway antibodies Hemostasis Pathway Diagram Herpes Simplex Infection Pathway antibodies Herpes Simplex Infection Pathway Diagram TOP © 2006-24 MyBioSource.com. 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