NP_446248.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
32,370 Da
NCBI Official Full Name
junctional adhesion molecule A
NCBI Official Synonym Full Names
F11 receptor
NCBI Official Synonym Symbols
NCBI Protein Information
junctional adhesion molecule A
UniProt Protein Name
Junctional adhesion molecule A
UniProt Synonym Protein Names
Junctional adhesion molecule 1; JAM-1; CD_antigen: CD321
UniProt Synonym Gene Names
UniProt Comments for JAM-A / F11R
JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q24
Cellular Component: cell junction; cytoplasmic vesicle; intercellular junction; microtubule cytoskeleton; plasma membrane; tight junction
Molecular Function: PDZ domain binding; protein binding
Biological Process: actomyosin structure organization and biogenesis; cell adhesion; cell differentiation; epithelial cell differentiation; intestinal absorption; positive regulation of blood pressure; positive regulation of GTPase activity; regulation of cytokine production; response to radiation
Research Articles on JAM-A / F11R
Precautions
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Pathways associated with JAM-A / F11R recombinant protein
Diseases associated with JAM-A / F11R recombinant protein
Organs/Tissues associated with JAM-A / F11R recombinant protein
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