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JAM3 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204249
SDS-Page
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
0.1 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JAM3, Recombinant Protein

★Popular Item★
 Also Known As   

JAM3, 32-241aa, Human, His tag, E Coli

 Product Synonym Names    Junctional adhesion molecule C; Junctional adhesion molecule 3; JAM-C; JAMC
 Product Gene Name   

JAM3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSMVNLKSS NRTPVVQEFE SVELSCIITD SQTSDPRIEW KKIQDEQTTY VFFDNKIQGD LAGRAEILGK TSLKIWNVTR RDSALYRCEV VARNDRKEID EIVIELTVQV KPVTPVCRVP KAVPVGKMAT LHCQESEGHP RPHYSWYRND VPLPTDSRAN PRFRNSSFHL NSETGTLVFT AVHKDDSGQY YCIASNDAGS ARCEEQEMEV YDLN
 OMIM    AF356518 mRNA
 3D Structure    ModBase 3D Structure for Q9BX67
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM EDTA, 5mM DTT
 Concentration    0.25 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of JAM3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for JAM3 recombinant protein

   Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. JAM3 is localized in the tight junctions between high endothelial cells. unlike other proteins in this family, this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. JAM3 is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. Recombinant human JAM3 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for JAM3 recombinant protein    Signal Transduction
 Applications Tested/Suitable for JAM3 recombinant protein   

SDS-PAGE

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 SDS-Page of JAM3 recombinant protein    JAM3 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for JAM3. It may not necessarily be applicable to this product.
 NCBI GI #    328927055
 NCBI GeneID    83700
 NCBI Accession #    NP_116190 [Other Products]
 NCBI GenBank Nucleotide #    NM_032801.4 [Other Products]
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 UniProt Primary Accession #    Q9BX67 [Other Products]
 UniProt Secondary Accession #    Q8WWL8; Q96FL1; B3KWG9 [Other Products]
 UniProt Related Accession #    Q9BX67 [Other Products]
 Molecular Weight    26 kDa (234aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    junctional adhesion molecule C isoform 1
 NCBI Official Synonym Full Names    junctional adhesion molecule 3
 NCBI Official Symbol    JAM3 [Similar Products]
 NCBI Official Synonym Symbols   
JAMC; JAM-2; JAM-3; JAM-C
[Similar Products]
 NCBI Protein Information    junctional adhesion molecule C
 UniProt Protein Name    Junctional adhesion molecule C
 UniProt Synonym Protein Names   
JAM-2; Junctional adhesion molecule 3; JAM-3
 Protein Family    Junctional adhesion molecule
 UniProt Gene Name    JAM3 [Similar Products]
 UniProt Synonym Gene Names    JAM-C; JAM-3 [Similar Products]
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 NCBI Summary for JAM3    Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
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 UniProt Comments for JAM3    Participates in cell-cell adhesion. It is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.
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Product References and Citations for JAM3 recombinant protein

   Santoso S., et al. (2002). J Exp Med. 2;196 (5):679-91.
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 Research Articles on JAM3    1. JAM-C controls Src family kinase (SFK) activation in leukemic stem cells and leukemia-initiating cell activity with exacerbated SFK activation was uniquely found within the JAM-C-expressing leukemic stem cell compartment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with JAM3 recombinant proteinDiseases associated with JAM3 recombinant protein
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >17 publications with JAM3 and Inflammation
 Uterine Cervical Neoplasms Antibodies  >6 publications with JAM3 and Uterine Cervical Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with JAM3 and Neoplasms, Experimental
 Heart Diseases Antibodies  >5 publications with JAM3 and Heart Diseases
 Necrosis Antibodies  >4 publications with JAM3 and Necrosis
 Infertility, Male Antibodies  >3 publications with JAM3 and Infertility, Male
 Cardiovascular Abnormalities Antibodies  >3 publications with JAM3 and Cardiovascular Abnormalities
 Heart Defects, Congenital Antibodies  >3 publications with JAM3 and Heart Defects, Congenital
 Lung Neoplasms Antibodies  >3 publications with JAM3 and Lung Neoplasms
 Fibrosis Antibodies  >2 publications with JAM3 and Fibrosis
Organs/Tissues associated with JAM3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >54 publications with JAM3 and Blood
 Vascular Antibodies  >37 publications with JAM3 and Vascular
 Brain Antibodies  >13 publications with JAM3 and Brain
 Lung Antibodies  >12 publications with JAM3 and Lung
 Heart Antibodies  >8 publications with JAM3 and Heart
 Bone Antibodies  >7 publications with JAM3 and Bone
 Embryonic Tissue Antibodies  >6 publications with JAM3 and Embryonic Tissue
 Nerve Antibodies  >6 publications with JAM3 and Nerve
 Skin Antibodies  >6 publications with JAM3 and Skin
 Kidney Antibodies  >5 publications with JAM3 and Kidney
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