NP_001091996.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,136 Da
NCBI Official Full Name
junctional adhesion molecule-like isoform 1
NCBI Official Synonym Full Names
junction adhesion molecule like
NCBI Official Synonym Symbols
AMICA; Gm638; AMICA1; CREA7-1; CREA7-4 [Similar Products]
NCBI Protein Information
junctional adhesion molecule-like
UniProt Protein Name
Junctional adhesion molecule-like
UniProt Synonym Protein Names
Adhesion molecule interacting with CXADR antigen 1; Dendritic cell-specific protein CREA7-1
UniProt Comments for JAML / AMICA
AMICA1: an adhesion molecule that may function in the migration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells. Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells. Three alternatively spliced isoforms have been described.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: plasma membrane; tight junction
Molecular Function: cell adhesion molecule binding; integrin binding; protein homodimerization activity
Biological Process: gamma-delta T cell activation; heterophilic cell adhesion; leukocyte migration; neutrophil chemotaxis; positive regulation of epithelial cell proliferation involved in wound healing; regulation of immune response
Research Articles on JAML / AMICA
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Pathways associated with JAML / AMICA recombinant protein
Diseases associated with JAML / AMICA recombinant protein
Organs/Tissues associated with JAML / AMICA recombinant protein
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