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JNK2/SAPK1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS142762 JNK2/SAPK1 recombinant protein
Unit / Price
0.001 mg  /  $140 +1 FREE 8GB USB
0.005 mg  /  $205 +1 FREE 8GB USB
0.2 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JNK2/SAPK1, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human JNK2/SAPK1

 Product Synonym Names    JNK2/SAPK1 Human; JNK2/SAPK1 Human Recombinant; Mitogen-activated protein kinase 9; EC 2.7.11.24; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2; JNK-55; JNK2; JNK2A; JNK2B; PRKM9; JNK2BETA; p54aSAPK; JNK2ALPHA; MAPK9; SAPK1
 Product Gene Name   

JNK2/SAPK1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602896
 3D Structure    ModBase 3D Structure for P45984
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    JNK2/SAPK1 (1.3 mg/ml) is supplied in 50mM Tris-HCl, 100mM NaCl, 1mM DTT, 50% glycerol, pH 8.
Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of JNK2/SAPK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for JNK2/SAPK1 recombinant protein

   Description: SAPK1/JNK2 Human Recombinant (stress-activated protein kinase/c-jun kinase) is a non-glycosilated polypeptide having a molecular mass of 49.5 kDa. SAPK1/JNK2 is purified by proprietary chromatographic techniques.

Introduction: JUN N-terminal Kinase 2is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
 Product Categories/Family for JNK2/SAPK1 recombinant protein    PROTEIN KINASES; Enzymes; Jun N-terminal Kinase
NCBI/Uniprot data below describe general gene information for JNK2/SAPK1. It may not necessarily be applicable to this product.
 NCBI GI #    205277412
 NCBI GeneID    5601
 NCBI Accession #    NP_001128516.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135044.1 [Other Products]
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 UniProt Primary Accession #    P45984 [Other Products]
 UniProt Secondary Accession #    Q15708; Q15710; Q15711; Q8N5C5; A8K0S3; B5BU66; B5M0B4; D3DWQ8; D3DWQ9 [Other Products]
 UniProt Related Accession #    P45984 [Other Products]
 Molecular Weight    27,334 Da
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 NCBI Official Full Name    mitogen-activated protein kinase 9 isoform JNK2 gamma
 NCBI Official Synonym Full Names    mitogen-activated protein kinase 9
 NCBI Official Symbol    MAPK9 [Similar Products]
 NCBI Official Synonym Symbols   
JNK2; SAPK; p54a; JNK2A; JNK2B; PRKM9; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase 9; Jun kinase; MAP kinase 9; MAPK 9; c-Jun N-terminal kinase 2; c-Jun kinase 2; stress-activated protein kinase 1a; stress-activated protein kinase JNK2
 UniProt Protein Name    Mitogen-activated protein kinase 9
 UniProt Synonym Protein Names   
JNK-55; Stress-activated protein kinase 1a; SAPK1a; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2
 UniProt Gene Name    MAPK9 [Similar Products]
 UniProt Synonym Gene Names    JNK2; PRKM9; SAPK1A; MAP kinase 9; MAPK 9; SAPK1a [Similar Products]
 UniProt Entry Name    MK09_HUMAN
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 NCBI Summary for JNK2/SAPK1    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
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 UniProt Comments for JNK2/SAPK1    JNK2: a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses including UV radiation. Phosphorylates specific transcription factors such as c-Jun and ATF2, mediating immediate-early gene expression. Closely related to JNK1. Both are involved in UV radiation induced apoptosis. Blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells in the mouse. Four alternatively-spliced isoforms have been described.

Protein type: Kinase, protein; Protein kinase, CMGC; EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); CMGC group; MAPK family; MAPK/JNK subfamily; JNK subfamily

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: nucleoplasm; mitochondrion; cytosol

Molecular Function: protein binding; caspase activator activity; mitogen-activated protein kinase kinase kinase binding; JUN kinase activity; transcription factor binding; ATP binding

Biological Process: positive regulation of nitric oxide biosynthetic process; central nervous system development; regulation of protein ubiquitination; response to toxin; positive regulation of transcription, DNA-dependent; rhythmic process; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; regulation of JNK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of transcription factor activity; response to stress; JNK cascade; toll-like receptor 4 signaling pathway; protein targeting to mitochondrion; neurite development; positive regulation of prostaglandin biosynthetic process; response to drug; caspase activation; release of cytochrome c from mitochondria; MyD88-independent toll-like receptor signaling pathway; regulation of circadian rhythm; positive regulation of chemokine production; toll-like receptor 2 signaling pathway; JUN phosphorylation; MyD88-dependent toll-like receptor signaling pathway; response to cadmium ion; response to mechanical stimulus; positive regulation of prostaglandin secretion; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; positive regulation of protein amino acid phosphorylation; response to amine stimulus; positive regulation of nitric-oxide synthase biosynthetic process
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 Research Articles on JNK2/SAPK1    1. Our findings demonstrate that AKT/mTOR and JNK2 signaling pathways are required for chrysotile asbestos-induced autophagy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with JNK2/SAPK1 recombinant proteinPathways associated with JNK2/SAPK1 recombinant protein
 Reference Product  PubMed Publications
 JUN recombinant protein  >12 publications with JNK2/SAPK1 and JUN
 FOS recombinant protein  >1 publications with JNK2/SAPK1 and FOS
 RAC1 recombinant protein  >1 publications with JNK2/SAPK1 and RAC1
 TP53 recombinant protein  >1 publications with JNK2/SAPK1 and TP53
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
Diseases associated with JNK2/SAPK1 recombinant proteinOrgans/Tissues associated with JNK2/SAPK1 recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4 publications with JNK2/SAPK1 and Breast Neoplasms
 Inflammation Antibodies  >4 publications with JNK2/SAPK1 and Inflammation
 Lung Neoplasms Antibodies  >3 publications with JNK2/SAPK1 and Lung Neoplasms
 Disease Models, Animal Antibodies  >3 publications with JNK2/SAPK1 and Disease Models, Animal
 Acute Kidney Injury Antibodies  >2 publications with JNK2/SAPK1 and Acute Kidney Injury
 Necrosis Antibodies  >2 publications with JNK2/SAPK1 and Necrosis
 Lung Diseases Antibodies  >1 publications with JNK2/SAPK1 and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with JNK2/SAPK1 and Carcinoma, Hepatocellular
 Edema Antibodies  >1 publications with JNK2/SAPK1 and Edema
 Kidney Diseases Antibodies  >1 publications with JNK2/SAPK1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with JNK2/SAPK1 and Blood
 Vascular Antibodies  >4 publications with JNK2/SAPK1 and Vascular
 Lung Antibodies  >4 publications with JNK2/SAPK1 and Lung
 Muscle Antibodies  >3 publications with JNK2/SAPK1 and Muscle
 Kidney Antibodies  >3 publications with JNK2/SAPK1 and Kidney
 Brain Antibodies  >2 publications with JNK2/SAPK1 and Brain
 Liver Antibodies  >1 publications with JNK2/SAPK1 and Liver
 Prostate Antibodies  >1 publications with JNK2/SAPK1 and Prostate
 Mammary Gland Antibodies  >1 publications with JNK2/SAPK1 and Mammary Gland
 Pancreas Antibodies  >1 publications with JNK2/SAPK1 and Pancreas
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