Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow JAG1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • BAFF (TNFSF13B) Antibody
 • Fibrinogen Like Protein 2 (FGL2) Recombinant Protein
 • Von Willebrand Factor (vWF) ELISA Kit
 • Dopamine (DA) ELISA Kit
 • Nuclear Factor-kappaB p65 (NF-kappaB p65) ELISA Kit
 • Protein Gene Product 9.5 (PGP9.5) Antibody
 • MADD (CT) Antibody
 • A Disintegrin Like and Metalloproteinase With Thrombospondin... ELISA Kit
 • Titin (TTN), partial Recombinant Protein
 • N-cadherin Antibody
 • Mouse IgE ELISA Kit
 • Growth Hormone Receptor (GHR) ELISA Kit
 • UCHL1 - PGP9.5 Antibody
 • Apolipoprotein-M (APOM) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

JAG1 recombinant protein :: Jagged 1 Protein (JAG1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2011360 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) JAG1 recombinant protein
Unit / Price
0.01 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $235 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
0.2 mg  /  $440 +1 FREE 8GB USB
0.5 mg  /  $845 +1 FREE 8GB USB
1 mg  /  $1,250 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Jagged 1 Protein (JAG1), Recombinant Protein

 Also Known As   

Recombinant Jagged 1 Protein (JAG1)

 Product Gene Name   

JAG1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF-G YRCICPPGYA GDHCERDIDE CASNPCLNGG HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC YNRASDYFCK CPEDYEGKNC SHLKDHCRTT PCEVIDSCTV AMASNDTPEG VRYISSNVCG PHGKCKSQSG GKFTCDCNKG FTGTYCHENI NDCESNPCRN GGTCIDGVNS YKCICSDGWE GAYCETNIND CSQNPCHNGG TCRDLVNDFY CDCKNGWKGK TCHSRDSQCD EATCNNGGTC YDEGDAFKCM CPGGWEGTTC NIARNSSCLP NPCHNGGTCV VNGESFTCVC KEGWEGPICA QNTNDCSPHP CYNSGTCVDG DNWYRCECAP GFAGPDCRIN INECQSSPCA FGAT
 Chromosome Location    Chromosome: 20; NC_000020.10 (10618332..10654694, complement). Location: 20p12.1-p11.23
 OMIM    118450
 3D Structure    ModBase 3D Structure for P78504
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Section Bar
 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Gly470~Thr834 (Accession # P78504) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
Section Bar
 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of JAG1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for JAG1 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for JAG1 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for JAG1. It may not necessarily be applicable to this product.
 NCBI GI #    4557679
 NCBI GeneID    182
 NCBI Accession #    NP_000205.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000214.2 [Other Products]
Section Bar
 UniProt Primary Accession #    P78504 [Other Products]
 UniProt Secondary Accession #    O14902; O15122; Q15816; A0AV43 [Other Products]
 UniProt Related Accession #    P78504 [Other Products]
 Molecular Weight    41.0kDa
Table BarTOPTable Bar
 NCBI Official Full Name    protein jagged-1
 NCBI Official Synonym Full Names    jagged 1
 NCBI Official Symbol    JAG1 [Similar Products]
 NCBI Official Synonym Symbols   
AGS; AHD; AWS; HJ1; CD339; JAGL1
[Similar Products]
 NCBI Protein Information    protein jagged-1
 UniProt Protein Name    Protein jagged-1
 Protein Family    Protein jagged
 UniProt Gene Name    JAG1 [Similar Products]
 UniProt Synonym Gene Names    JAGL1; Jagged1; hJ1 [Similar Products]
 UniProt Entry Name    JAG1_HUMAN
Section Bar
 NCBI Summary for JAG1    The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for JAG1    JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p12.1-p11.23

Cellular Component: membrane; integral to plasma membrane; apical part of cell; plasma membrane; extracellular region

Molecular Function: protein binding; growth factor activity; calcium ion binding; structural molecule activity; Notch binding

Biological Process: nervous system development; endothelial cell differentiation; Notch signaling pathway; positive regulation of myeloid cell differentiation; T cell mediated immunity; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; keratinocyte differentiation; myoblast differentiation; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; hemopoiesis; angiogenesis; positive regulation of Notch signaling pathway

Disease: Tetralogy Of Fallot; Alagille Syndrome 1
Table BarTOPTable Bar
 Research Articles on JAG1    1. derived mesenchymal stem cells (hPDLSCs) on a Jagged-1-modified surface had increased expression of Notch signaling target genes, Hes-1 and Hey-1, suggesting the involvement of Notch signaling in hPDLSCs.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with JAG1 recombinant proteinPathways associated with JAG1 recombinant protein
 Reference Product  PubMed Publications
 NOTCH1 recombinant protein  >67 publications with JAG1 and NOTCH1
 NOTCH2 recombinant protein  >46 publications with JAG1 and NOTCH2
 DLL1 recombinant protein  >28 publications with JAG1 and DLL1
 NOTCH3 recombinant protein  >26 publications with JAG1 and NOTCH3
 HES5 recombinant protein  >16 publications with JAG1 and HES5
 MIB1 recombinant protein  >2 publications with JAG1 and MIB1
 ADAM10 recombinant protein  >1 publications with JAG1 and ADAM10
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
Diseases associated with JAG1 recombinant proteinOrgans/Tissues associated with JAG1 recombinant protein
 Disease Name  Pubmed Publications
 Alagille Syndrome Antibodies  >120 publications with JAG1 and Alagille Syndrome
 Heart Defects, Congenital Antibodies  >106 publications with JAG1 and Heart Defects, Congenital
 Liver Diseases Antibodies  >103 publications with JAG1 and Liver Diseases
 Neoplasms Antibodies  >61 publications with JAG1 and Neoplasms
 Facies Antibodies  >29 publications with JAG1 and Facies
 Heart Diseases Antibodies  >26 publications with JAG1 and Heart Diseases
 Breast Neoplasms Antibodies  >20 publications with JAG1 and Breast Neoplasms
 Eye Abnormalities Antibodies  >15 publications with JAG1 and Eye Abnormalities
 Tetralogy of Fallot Antibodies  >15 publications with JAG1 and Tetralogy of Fallot
 Bone Diseases Antibodies  >13 publications with JAG1 and Bone Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >70 publications with JAG1 and Liver
 Heart Antibodies  >50 publications with JAG1 and Heart
 Vascular Antibodies  >43 publications with JAG1 and Vascular
 Blood Antibodies  >40 publications with JAG1 and Blood
 Eye Antibodies  >30 publications with JAG1 and Eye
 Embryonic Tissue Antibodies  >26 publications with JAG1 and Embryonic Tissue
 Brain Antibodies  >25 publications with JAG1 and Brain
 Ear Antibodies  >23 publications with JAG1 and Ear
 Kidney Antibodies  >18 publications with JAG1 and Kidney
 Muscle Antibodies  >13 publications with JAG1 and Muscle
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions