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JAK2 recombinant protein :: Janus Kinase 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142815 JAK2 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Janus Kinase 2 (JAK2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Janus Kinase 2

 Product Gene Name   

JAK2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHH HHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMGE SPIFWYAPES LTESKFSVAS DVWSFGVVLY ELFTYIEKSK SPPAEFMRMI GNDKQGQMIV FHLIELLKNN GRLPRPDGCP DEIYMIMTEC WNNNVNQRPS FRDLALRVDQ IRDNMAG.
 OMIM    176977
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    JAK2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of JAK2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for JAK2 recombinant protein

   JAK2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 157 amino acids (1014-1132 a.a) and having a molecular mass of 18.1kDa. JAK2 is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
 Product Categories/Family for JAK2 recombinant protein    PROTEIN KINASES
NCBI/Uniprot data below describe general gene information for JAK2. It may not necessarily be applicable to this product.
 NCBI GI #    31377782
 NCBI GeneID    5580
 NCBI Accession #    NP_006245.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006254.3 [Other Products]
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 UniProt Secondary Accession #    Q15144; Q86XJ6; B0KZ81; B2R834 [Other Products]
 UniProt Related Accession #    Q05655 [Other Products]
 Molecular Weight    80,953 Da
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 NCBI Official Full Name    protein kinase C delta type
 NCBI Official Synonym Full Names    protein kinase C, delta
 NCBI Official Symbol    PRKCD [Similar Products]
 NCBI Official Synonym Symbols   
MAY1; PKCD; ALPS3; CVID9; nPKC-delta
[Similar Products]
 NCBI Protein Information    protein kinase C delta type; protein kinase C delta VIII; tyrosine-protein kinase PRKCD
 UniProt Protein Name    Protein kinase C delta type
 UniProt Synonym Protein Names   
Tyrosine-protein kinase PRKCD (EC:2.7.10.2); nPKC-deltaCleaved into the following 2 chains:Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunitAlternative name(s):Sphingosine-dependent protein kinase-1; SDK1
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    PRKCD [Similar Products]
 UniProt Synonym Gene Names    SDK1 [Similar Products]
 UniProt Entry Name    KPCD_HUMAN
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 NCBI Summary for JAK2    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
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 UniProt Comments for JAK2    PKCD: an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities.

Protein type: Tumor suppressor; Nuclear receptor co-regulator; EC 2.7.11.13; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Delta subfamily

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: nucleoplasm; nuclear matrix; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; intercellular junction; cytosol; nucleus

Molecular Function: calcium-independent protein kinase C activity; protein serine/threonine kinase activity; protein binding; protein kinase C activity; enzyme binding; metal ion binding; insulin receptor substrate binding; enzyme activator activity; non-membrane spanning protein tyrosine kinase activity; ATP binding

Biological Process: B cell proliferation; negative regulation of MAP kinase activity; interleukin-12 production; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; apoptosis; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of filopodium formation; positive regulation of superoxide release; regulation of receptor activity; negative regulation of protein binding; cell structure disassembly during apoptosis; epidermal growth factor receptor signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; platelet activation; fibroblast growth factor receptor signaling pathway; protein stabilization; neutrophil activation; negative regulation of actin filament polymerization; cytokine and chemokine mediated signaling pathway; peptidyl-threonine phosphorylation; cell cycle; phospholipase C activation; negative regulation of inflammatory response; defense response to bacterium; interleukin-10 production; innate immune response; gene expression; immunoglobulin mediated immune response; vascular endothelial growth factor receptor signaling pathway; blood coagulation; induction of apoptosis by oxidative stress

Disease: Autoimmune Lymphoproliferative Syndrome, Type Iii
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 Research Articles on JAK2    1. There is a PRKCD-dependent proapoptotic mechanism controlling stability of HAX-1, a proto-oncogene in mantle cell lymphoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with JAK2 recombinant proteinPathways associated with JAK2 recombinant protein
 Reference Product  PubMed Publications
 SRC recombinant protein  >64 publications with JAK2 and SRC
 STAT1 recombinant protein  >10 publications with JAK2 and STAT1
 STAT3 recombinant protein  >8 publications with JAK2 and STAT3
 PTK2B recombinant protein  >6 publications with JAK2 and PTK2B
 FYN recombinant protein  >6 publications with JAK2 and FYN
 IRS1 recombinant protein  >6 publications with JAK2 and IRS1
 SHC1 recombinant protein  >3 publications with JAK2 and SHC1
 RAF1 recombinant protein  >1 publications with JAK2 and RAF1
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 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Ca-dependent Events Pathway antibodies  Ca-dependent Events Pathway Diagram
 CaM Pathway antibodies  CaM Pathway Diagram
Diseases associated with JAK2 recombinant proteinOrgans/Tissues associated with JAK2 recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >48 publications with JAK2 and Necrosis
 Heart Diseases Antibodies  >47 publications with JAK2 and Heart Diseases
 Nervous System Diseases Antibodies  >39 publications with JAK2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >35 publications with JAK2 and Disease Models, Animal
 Inflammation Antibodies  >33 publications with JAK2 and Inflammation
 Hypertrophy Antibodies  >23 publications with JAK2 and Hypertrophy
 Breast Neoplasms Antibodies  >20 publications with JAK2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >18 publications with JAK2 and Adenocarcinoma
 Cardiomyopathies Antibodies  >17 publications with JAK2 and Cardiomyopathies
 Hyperglycemia Antibodies  >16 publications with JAK2 and Hyperglycemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >142 publications with JAK2 and Blood
 Heart Antibodies  >91 publications with JAK2 and Heart
 Vascular Antibodies  >76 publications with JAK2 and Vascular
 Brain Antibodies  >69 publications with JAK2 and Brain
 Nerve Antibodies  >38 publications with JAK2 and Nerve
 Kidney Antibodies  >34 publications with JAK2 and Kidney
 Liver Antibodies  >30 publications with JAK2 and Liver
 Lung Antibodies  >29 publications with JAK2 and Lung
 Skin Antibodies  >28 publications with JAK2 and Skin
 Bone Antibodies  >22 publications with JAK2 and Bone
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