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KAT2A recombinant protein :: K (lysine) Acetyltransferase 2A Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144461 KAT2A recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

K (lysine) Acetyltransferase 2A (KAT2A), Recombinant Protein

 Also Known As   

Recombinant Human K (lysine) Acetyltransferase 2A

 Product Synonym Names    KAT2A Human; K (lysine) Acetyltransferase 2A Human Recombinant; Histone acetyltransferase KAT2A; General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; HsGCN5; Lysine acetyltransferase 2A; STAF97; KAT2A; GCN5; GCN5L2; HGCN5; PCAF-b
 Product Gene Name   

KAT2A recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MGGGSNSSLS LDSAGAEPMP GEKRTLPENL TLEDAKRLRV MGDIPMELVN EVMLTITDPA AMLGPETSLL SANAARDETA RLEERRGIIE FHVIGNSLTP KANRRVLLWL VGLQNVFSHQ LPRMPKEYIA RLVFDPKHKT LALIKDGRVI GGICFRMFPT QGFTEIVFCA VTSNEQVKGY GTHLMNHLKE YHIKHNILYF LTYADEYAIG YFKKQGFSKD IKVPKSRYLG YIKDYEGATL MECELNPRIP YTELSHIIKK QKEIIKKLIE RKQAQIRKVY PGLSCFKEGV RQIPVESVPG IRETGWKPLG KEKGKELKDP DQLYTTLKNL LAQIKSHPSA WPFMEPVKKS EAPDYYEVIR FPIDLKTMTE RLRSRYYVTR KLFVADLQRV IANCREYNPP DSEYCRCASA LEKFFYFKLK EGGLIDK
 OMIM    602301
 3D Structure    ModBase 3D Structure for Q92830
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    KAT2A protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 5mM DTT, 40% glycerol, 200mM NaCl and 1mM EDTA.
Sterile Filtered colorless solution.
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 Other Notes    Small volumes of KAT2A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for KAT2A recombinant protein

   Description: KAT2A Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 447 amino acids (411-837 a.a) and having a molecular mass of 51.1kDa.KAT2A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: General control of amino acid synthesis protein 5 like 2 (KAT2A) is a member of the GCN5 family. KAT2A functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. KAT2A interacts with Ku70, TAF9, transcription initiation protein SPT3 homolog, TADA2L, Ku80 and DDB1.
 Product Categories/Family for KAT2A recombinant protein    ENZYMES; Enzymes; Transferase
NCBI/Uniprot data below describe general gene information for KAT2A. It may not necessarily be applicable to this product.
 NCBI GI #    153791535
 NCBI GeneID    2648
 NCBI Accession #    NP_066564.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_021078.2 [Other Products]
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 UniProt Primary Accession #    Q92830 [Other Products]
 UniProt Secondary Accession #    Q8N1A2; Q9UCW1 [Other Products]
 UniProt Related Accession #    Q92830 [Other Products]
 Molecular Weight    48,921 Da
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 NCBI Official Full Name    histone acetyltransferase KAT2A
 NCBI Official Synonym Full Names    K(lysine) acetyltransferase 2A
 NCBI Official Symbol    KAT2A [Similar Products]
 NCBI Official Synonym Symbols   
GCN5; hGCN5; GCN5L2; PCAF-b
[Similar Products]
 NCBI Protein Information    histone acetyltransferase KAT2A; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; General control of amino acid synthesis, yeast, homolog-like 2; STAF97; general control of amino acid synthesis protein 5-like 2; histone acetyltransferase GCN5; hsGCN5; lysine acetyltransferase 2A
 UniProt Protein Name    Histone acetyltransferase KAT2A
 UniProt Synonym Protein Names   
General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; HsGCN5; Lysine acetyltransferase 2A; STAF97
 Protein Family    Histone acetyltransferase
 UniProt Gene Name    KAT2A [Similar Products]
 UniProt Synonym Gene Names    GCN5; GCN5L2; HGCN5; HsGCN5 [Similar Products]
 UniProt Entry Name    KAT2A_HUMAN
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 NCBI Summary for KAT2A    KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
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 UniProt Comments for KAT2A    GCN5: an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described.

Protein type: Acetyltransferase; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleoplasm; extracellular space

Molecular Function: protein binding; histone acetyltransferase activity; histone deacetylase binding; transcription coactivator activity; chromatin binding; H3 histone acetyltransferase activity

Biological Process: transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; somitogenesis; viral reproduction; in utero embryonic development; multicellular organism growth; regulation of protein stability; metencephalon development; histone deubiquitination; regulation of transcription from RNA polymerase II promoter; chromatin remodeling; cell proliferation; telencephalon development; neural tube closure; midbrain development
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 Research Articles on KAT2A    1. Purified GCN5 binds to an N-terminal sub-domain of MYC TAD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KAT2A recombinant proteinPathways associated with KAT2A recombinant protein
 Reference Product  PubMed Publications
 MYC recombinant protein  >8 publications with KAT2A and MYC
 TRRAP recombinant protein  >7 publications with KAT2A and TRRAP
 TADA2A recombinant protein  >3 publications with KAT2A and TADA2A
 TAF4 recombinant protein  >2 publications with KAT2A and TAF4
 TAF10 recombinant protein  >2 publications with KAT2A and TAF10
 SUPT3H recombinant protein  >1 publications with KAT2A and SUPT3H
 Products by Pathway  Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
Diseases associated with KAT2A recombinant proteinOrgans/Tissues associated with KAT2A recombinant protein
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with KAT2A and Brain Diseases
 Nervous System Diseases Antibodies  >2 publications with KAT2A and Nervous System Diseases
 Liver Diseases Antibodies  >2 publications with KAT2A and Liver Diseases
 Kidney Diseases Antibodies  >2 publications with KAT2A and Kidney Diseases
 Body Weight Changes Antibodies  >1 publications with KAT2A and Body Weight Changes
 Nerve Degeneration Antibodies  >1 publications with KAT2A and Nerve Degeneration
 Fatty Liver Antibodies  >1 publications with KAT2A and Fatty Liver
 Fibrosis Antibodies  >1 publications with KAT2A and Fibrosis
 Ovarian Diseases Antibodies  >1 publications with KAT2A and Ovarian Diseases
 Musculoskeletal Abnormalities Antibodies  >1 publications with KAT2A and Musculoskeletal Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with KAT2A and Liver
 Blood Antibodies  >3 publications with KAT2A and Blood
 Muscle Antibodies  >2 publications with KAT2A and Muscle
 Kidney Antibodies  >2 publications with KAT2A and Kidney
 Lung Antibodies  >2 publications with KAT2A and Lung
 Nerve Antibodies  >2 publications with KAT2A and Nerve
 Brain Antibodies  >2 publications with KAT2A and Brain
 Bone Antibodies  >1 publications with KAT2A and Bone
 Eye Antibodies  >1 publications with KAT2A and Eye
 Intestine Antibodies  >1 publications with KAT2A and Intestine
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