NP_066564.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
histone acetyltransferase KAT2A
NCBI Official Synonym Full Names
K(lysine) acetyltransferase 2A
NCBI Protein Information
histone acetyltransferase KAT2A; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; General control of amino acid synthesis, yeast, homolog-like 2; STAF97; general control of amino acid synthesis protein 5-like 2; histone acetyltransferase GCN5; hsGCN5; lysine acetyltransferase 2A
UniProt Protein Name
Histone acetyltransferase KAT2A
UniProt Synonym Protein Names
General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; HsGCN5; Lysine acetyltransferase 2A; STAF97
UniProt Synonym Gene Names
UniProt Entry Name
KAT2A_HUMAN
NCBI Summary for KAT2A
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
UniProt Comments for KAT2A
GCN5: an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described.
Protein type: Acetyltransferase; EC 2.3.1.48
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: nucleoplasm; extracellular space
Molecular Function: protein binding; histone acetyltransferase activity; histone deacetylase binding; transcription coactivator activity; chromatin binding; H3 histone acetyltransferase activity
Biological Process: transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; somitogenesis; viral reproduction; in utero embryonic development; multicellular organism growth; regulation of protein stability; metencephalon development; histone deubiquitination; regulation of transcription from RNA polymerase II promoter; chromatin remodeling; cell proliferation; telencephalon development; neural tube closure; midbrain development
Research Articles on KAT2A
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Products associated with KAT2A recombinant protein
Pathways associated with KAT2A recombinant protein
Diseases associated with KAT2A recombinant protein
Organs/Tissues associated with KAT2A recombinant protein
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