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KIR3DL1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203057
SDS-PAGE
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KIR3DL1, Recombinant Protein

 Also Known As   

KIR3DL1(Cytoplasmic tail, 361-444aa, His-tag, Human), Recombinant, E Coli

 Product Synonym Names    KIR3DL1; CD158E; NKAT3; NKB1; KIR3DL1 (Cytoplasmic tail; 361-444aa); MHC class I NK cell receptor; Natural killer-associated transcript 3; NKAT-3; p70 natural killer cell receptor clones CL-2/CL-11; HLA-BW4-specific inhibitory NK cell receptor; CD1; Killer cell immunoglobulin-like receptor 3DL1; Killer cell immunoglobulin-like receptor 3DL1 AMB11; CD158 antigen-like family member E; CD158e antigen; CD158E1; CD158E1/2; CD158E2; CL11; CL2; HLA-BW4-specific inhibitory NK cell receptor; killer cell immunoglobulin like receptor; Killer cell immunoglobulin like receptor three domains; short cytoplasmic tail; 1; Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1; KIR; KIR antigen 3DL1; KIR G1; KIR3DS1; Kirl1; Kirl2; Krl1; MGC119726; MGC119728; MGC126589; MGC126591; Natural killer associated transcript 3; Natural killer cell inhibitory receptor; NK receptor; NK-associated transcript 10; NK-associated transcript 3; NK-associated transcript 3delIg1; NKAT10; NKB1B; p70 killer cell inhibitory receptor
 Product Gene Name   

KIR3DL1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSTSGT IDKLDIEFHL WCSNKKNAAV MDQEPAGNRT ANSEDSDEQD PEEVTYAQLD HCVFTQRKIT RPSQRPKTPP TDTILYTELP NAKPRSKVVS CP
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In 25 mM Tris-HCl (pH7.5) 100mM NaCl
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of KIR3DL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for KIR3DL1 recombinant protein

   The three Ig-domain from of inhibitory killer cell Ig-like receptor 1(KIR3DL1,NKB1, nkat3, p70KIR) is a NK cell receptor for polymorphic HLA-B determinant. KIR3DL1 recognizes the Bw4 determinant defined by sequence motifs at positins 77-83 of the HLA-B heavy chain. The cytoplasmic tail of KIR, which contains two immunoreceptor tyrosine-based inhibition motifs(ITIMs), mediates inhibitory signal transduction that prevents killer cell-mediated cytotoxicity. A His-tag fusion protein of KIR3DL1 cytoplasmic tail(361-444aa) was overexpressed as insoluble protein aggregates(inclusion bodies). This protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer
 Product Categories/Family for KIR3DL1 recombinant protein    NK Cell Receptors
 Applications Tested/Suitable for KIR3DL1 recombinant protein   

SDS-PAGE

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 SDS-PAGE of KIR3DL1 recombinant protein    KIR3DL1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for KIR3DL1. It may not necessarily be applicable to this product.
 NCBI GI #    134268644
 NCBI GeneID    3811
 NCBI Accession #    NP_037421 [Other Products]
 NCBI GenBank Nucleotide #    NM_013289.2 [Other Products]
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 UniProt Secondary Accession #    O43473; Q14946; Q16541 [Other Products]
 UniProt Related Accession #    P43629 [Other Products]
 Molecular Weight    15 kDa (132 aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    killer cell immunoglobulin-like receptor 3DL1
 NCBI Official Synonym Full Names    killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
 NCBI Official Symbol    KIR3DL1 [Similar Products]
 NCBI Official Synonym Symbols   
KIR; NKB1; NKAT3; NKB1B; NKAT-3; CD158E1; KIR3DL1/S1
[Similar Products]
 NCBI Protein Information    killer cell immunoglobulin-like receptor 3DL1; CD158 antigen-like family member E; HLA-BW4-specific inhibitory NK cell receptor; KIR antigen 3DL1; MHC class I NK cell receptor; NK-receptor; killer Ig receptor; natural killer-associated transcript 3; p70 NK receptor CL-2/CL-11; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clones CL-2/CL-11
 UniProt Protein Name    Killer cell immunoglobulin-like receptor 3DL1
 UniProt Synonym Protein Names   
CD158 antigen-like family member E; HLA-BW4-specific inhibitory NK cell receptor; MHC class I NK cell receptor; Natural killer-associated transcript 3; NKAT-3; p70 natural killer cell receptor clones CL-2/CL-11; p70 NK receptor CL-2/CL-11; CD_antigen: CD158e
 Protein Family    Killer cell immunoglobulin-like receptor
 UniProt Gene Name    KIR3DL1 [Similar Products]
 UniProt Synonym Gene Names    CD158E; NKAT3; NKB1; NKAT-3; p70 NK receptor CL-2/CL-11 [Similar Products]
 UniProt Entry Name    KI3L1_HUMAN
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 NCBI Summary for KIR3DL1    Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KIR3DL1    KIR3DL1: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: HLA-B specific inhibitory MHC class I receptor activity

Biological Process: regulation of immune response; immune response; signal transduction

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
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Product References and Citations for KIR3DL1 recombinant protein

   Chan HW., et al. (2003) J. Exp. Med. 197(2), 245-55.
Gardiner CM., et al. (2001) J Immunol. 166(5):2992-3001.
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 Research Articles on KIR3DL1    1. The frequency of KIR3DL1 with HLA-Bw4 was significantly lower in diffuse large B-cell lymphoma patients than in controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KIR3DL1 recombinant proteinPathways associated with KIR3DL1 recombinant protein
 Reference Product  PubMed Publications
 HLA-C recombinant protein  >39 publications with KIR3DL1 and HLA-C
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram
Diseases associated with KIR3DL1 recombinant proteinOrgans/Tissues associated with KIR3DL1 recombinant protein
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >68 publications with KIR3DL1 and Immune System Diseases
 HIV Infections Antibodies  >40 publications with KIR3DL1 and HIV Infections
 Cardiovascular Diseases Antibodies  >7 publications with KIR3DL1 and Cardiovascular Diseases
 Liver Diseases Antibodies  >6 publications with KIR3DL1 and Liver Diseases
 Carcinoma Antibodies  >6 publications with KIR3DL1 and Carcinoma
 Gastrointestinal Diseases Antibodies  >6 publications with KIR3DL1 and Gastrointestinal Diseases
 Nervous System Diseases Antibodies  >5 publications with KIR3DL1 and Nervous System Diseases
 Diabetes Mellitus Antibodies  >4 publications with KIR3DL1 and Diabetes Mellitus
 Colorectal Neoplasms Antibodies  >4 publications with KIR3DL1 and Colorectal Neoplasms
 Skin Neoplasms Antibodies  >3 publications with KIR3DL1 and Skin Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with KIR3DL1 and Liver
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