NP_002251
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18.4 kDa (162aa)
NCBI Official Full Name
NKG2-C type II integral membrane protein
NCBI Official Synonym Full Names
killer cell lectin like receptor C2
NCBI Protein Information
NKG2-C type II integral membrane protein
UniProt Protein Name
NKG2-C type II integral membrane protein
UniProt Synonym Protein Names
CD159 antigen-like family member C; NK cell receptor C; NKG2-C-activating NK receptor; CD_antigen: CD159c
UniProt Synonym Gene Names
NCBI Summary for KLRC2
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for KLRC2
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Product References and Citations for KLRC2 recombinant protein
Houchins J.P., et al. (1991) J. Exp. Med. 173:1017-1020; Shum B.P., et al. (2002) J. Immunol. 168:240-252
Research Articles on KLRC2
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Products associated with KLRC2 recombinant protein
Pathways associated with KLRC2 recombinant protein
Diseases associated with KLRC2 recombinant protein
Organs/Tissues associated with KLRC2 recombinant protein
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