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KRT8 recombinant protein :: Keratin, type II cytoskeletal 8 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS967725
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Unit / Price
0.05 mg (E-Coli)  /  $900 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $990 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,115 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,210 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,330 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,330 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,360 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,410 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,505 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,895 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,025 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,055 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,290 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Keratin, type II cytoskeletal 8 (KRT8), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Keratin, type II cytoskeletal 8

 Product Synonym Names    Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
 Product Gene Name   

KRT8 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-483aa; Full Length
 Sequence    SIRVTQKSYK VSTSGPRAFS SRSYTSGPGS RISSSSFSRV GSSNFRGGLG GGYGGASGMG GITAVTVNQS LLSPLVLEVD PNIQAVRTQE KEQIKTLNNK FASFIDKVRF LEQQNKMLET KWSLLQQQKT ARSNMDNMFE SYINNLRRQL ETLGQEKLKL EAELGNMQGL VEDFKNKYED EINKRTEMEN EFVLIKKDVD EAYMNKVELE SRLEGLTDEI NFLRQLYEEE IRELQSQISD TSVVLSMDNS RSLDMDSIIA EVKAQYEDIA NRSRAEAESM YQIKYEELQS LAGKHGDDLR RTKTEISEMN RNISRLQAEI EGLKGQRASL EAAIADAEQR GELAIKDANA KLSELEAALQ RAKQDMARQL REYQELMNVK LALDIEIATY RKLLEGEESR LESGMQNMSI HTKTTSGYAG GLSSAYGGLT SPGLSYSLGS SFGSGAGSSS FSRTSSSRAV VVKKIETRDG KLVSESSDVL PK
 OMIM    148060
 3D Structure    ModBase 3D Structure for P05787
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of KRT8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for KRT8 recombinant protein

   Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
 Product Categories/Family for KRT8 recombinant protein    Immunology
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 SDS-Page of KRT8 recombinant protein    KRT8 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for KRT8. It may not necessarily be applicable to this product.
 NCBI GI #    372466577
 NCBI GeneID    3856
 NCBI Accession #    NP_001243222.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256293.1 [Other Products]
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 UniProt Primary Accession #    P05787 [Other Products]
 UniProt Secondary Accession #    Q14099; Q14716; Q14717; Q53GJ0; Q6DHW5; Q6GMY0; Q6P4C7; Q96J60; A8K4H3; B0AZN5; F8VXB4 [Other Products]
 UniProt Related Accession #    P05787 [Other Products]
 Molecular Weight    69.54kD
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 NCBI Official Full Name    keratin, type II cytoskeletal 8 isoform 2
 NCBI Official Synonym Full Names    keratin 8, type II
 NCBI Official Symbol    KRT8 [Similar Products]
 NCBI Official Synonym Symbols   
K8; KO; CK8; CK-8; CYK8; K2C8; CARD2
[Similar Products]
 NCBI Protein Information    keratin, type II cytoskeletal 8
 UniProt Protein Name    Keratin, type II cytoskeletal 8
 UniProt Synonym Protein Names   
Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
 Protein Family    Keratin
 UniProt Gene Name    KRT8 [Similar Products]
 UniProt Synonym Gene Names    CYK8; CK-8; K8 [Similar Products]
 UniProt Entry Name    K2C8_HUMAN
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 NCBI Summary for KRT8    This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for KRT8    K8: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Phsophorylated by p38 kinase, regulating cellular keratin filament reorganization. Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Mutation of this protein is a risk factor for cryptogenic liver failure.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: costamere; cytoplasm; dystrophin-associated glycoprotein complex; intercellular junction; intermediate filament; keratin filament; nuclear matrix; nucleoplasm; nucleus; sarcolemma; Z disc

Molecular Function: protein binding; protein complex binding; structural molecule activity

Biological Process: response to hydrostatic pressure; response to other organism; sarcomere organization; tumor necrosis factor-mediated signaling pathway; viral reproduction

Disease: Cirrhosis, Familial
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Product References and Citations for KRT8 recombinant protein

   Organization and sequence of the human gene encoding cytokeratin 8.Krauss S., Franke W.W.Gene 86:241-249(1990) Cloning and sequence of cDNA for human placental cytokeratin 8. Regulation of the mRNA in trophoblastic cells by cAMP.Yamamoto R., Kao L.C., McKnight C.E., Strauss J.F. IIIMol. Endocrinol. 4:370-374(1990) Embryonic simple epithelial keratins 8 and 18 chromosomal location emphasizes difference from other keratin pairs.Waseem A., Alexander C.M., Steel J.B., Lane E.B.New Biol. 2:464-478(1990) Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.Ku N.-O., Omary M.B.J. Biol. Chem. 272:7556-7564(1997) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. The finished DNA sequence of human chromosome 12.Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.Nature 440:346-351(2006)
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 Research Articles on KRT8    1. Variants in highly conserved residues of K8 Lys393Arg (ezetimibe/simvastatin-related) was found in patients with fatal Drug-induced liver injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KRT8 recombinant proteinPathways associated with KRT8 recombinant protein
 Reference Product  PubMed Publications
 KRT18 recombinant protein  >58 publications with KRT8 and KRT18
 TP53 recombinant protein  >5 publications with KRT8 and TP53
 TCHP recombinant protein  >1 publications with KRT8 and TCHP
 TDGF1 recombinant protein  >1 publications with KRT8 and TDGF1
 PPL recombinant protein  >1 publications with KRT8 and PPL
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Signaling Mediated By P38-alpha And P38-beta Pathway antibodies  Signaling Mediated By P38-alpha And P38-beta Pathway Diagram
Diseases associated with KRT8 recombinant proteinOrgans/Tissues associated with KRT8 recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >40 publications with KRT8 and Liver Diseases
 Breast Neoplasms Antibodies  >18 publications with KRT8 and Breast Neoplasms
 Adenocarcinoma Antibodies  >17 publications with KRT8 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >14 publications with KRT8 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >14 publications with KRT8 and Disease Models, Animal
 Fibrosis Antibodies  >12 publications with KRT8 and Fibrosis
 Liver Cirrhosis Antibodies  >10 publications with KRT8 and Liver Cirrhosis
 Liver Neoplasms Antibodies  >10 publications with KRT8 and Liver Neoplasms
 Necrosis Antibodies  >8 publications with KRT8 and Necrosis
 Drug-Induced Liver Injury Antibodies  >8 publications with KRT8 and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >53 publications with KRT8 and Liver
 Skin Antibodies  >19 publications with KRT8 and Skin
 Embryonic Tissue Antibodies  >15 publications with KRT8 and Embryonic Tissue
 Bone Antibodies  >10 publications with KRT8 and Bone
 Mouth Antibodies  >9 publications with KRT8 and Mouth
 Kidney Antibodies  >9 publications with KRT8 and Kidney
 Lung Antibodies  >8 publications with KRT8 and Lung
 Prostate Antibodies  >7 publications with KRT8 and Prostate
 Mammary Gland Antibodies  >6 publications with KRT8 and Mammary Gland
 Lymph Antibodies  >6 publications with KRT8 and Lymph
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