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FGF10 recombinant protein :: Keratinocyte Growth Factor 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS650907 FGF10 recombinant protein
Unit / Price
0.005 mg  /  $315 +1 FREE 8GB USB
0.025 mg  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Keratinocyte Growth Factor 2 (FGF10), Recombinant Protein

 Also Known As   

Keratinocyte Growth Factor 2, Recombinant, Human (KGF2)

 Product Gene Name   

FGF10 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (44305097..44388784, complement). Location: 5p13-p12
 OMIM    149730
 3D Structure    ModBase 3D Structure for O15520
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 Host    E Coli
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 Purity/Purification    Highly Purified
95% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.
 Form/Format    Supplied as a lyophilized powder in 5mM sodium phosphate, pH 7.4, 80mM sodium chloride.
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 Biological Activity    Recombinant Keratinocye Growth Factor-2 is fully biologically active when compared to standards. The ED50, calculated by the dose-dependent stimulation of FGF recpetors by BaF3 indicator cells (measured by 3H-thymidine uptake) is less then 0.5ng/ml corresponding to a specific activity of 2 x 10e6 Units/mg.
 Dimers and Aggregates    1% as determined by silver-stained SDS-PAGE gel analysis.
 Endotoxin Level    0.1ng/ug (IEU/ug) of KGF-2.
 Protein Content    Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280nm using the absorbency value of 1.79 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
2. Analysis by RP-HPLC, using a calibrated solution of KGF-2 as a Reference Standard.
 Reconstitution    Reconstitute the lyophilized KGF-2 in sterile 18M -cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
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 Preparation and Storage    Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile dH2O and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of FGF10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FGF10 recombinant protein

   KGF is a potent specific mitogen for many epithelial cells but not for fibroblasts and endothelial cells. KGF is thought to play an important role in the paracrine growth control of normal epithelial cells.

Recombinant Human KGF-2 (FGF-10) is a single, non-glycosylated polypeptide chain containing 170 amino acids and having a molecular mass of 19300 Dalton. rHuKGF-2 is highly related to KGF-1(FGF-7), it binds to the same receptor as KGF-1 and shares 57% sequence homology.
 Product Categories/Family for FGF10 recombinant protein    Growth Factors, Cytokines; Growth Factors-KGF
NCBI/Uniprot data below describe general gene information for FGF10. It may not necessarily be applicable to this product.
 NCBI GI #    2231295
 NCBI GeneID    2255
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 UniProt Primary Accession #    O15520 [Other Products]
 UniProt Secondary Accession #    Q6FHT6; Q96P59 [Other Products]
 UniProt Related Accession #    O15520; Q6FHR3; Q8NFI9 [Other Products]
 Molecular Weight    23,436 Da [Similar Products]
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 NCBI Official Full Name    keratinocyte growth factor 2
 NCBI Official Synonym Full Names    fibroblast growth factor 10
 NCBI Official Symbol    FGF10 [Similar Products]
 NCBI Protein Information    fibroblast growth factor 10; FGF-10; OTTHUMP00000161804; keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria
 UniProt Protein Name    Fibroblast growth factor 10
 UniProt Synonym Protein Names   
Keratinocyte growth factor 2
 Protein Family    Fibroblast growth factor
 UniProt Gene Name    FGF10 [Similar Products]
 UniProt Entry Name    FGF10_HUMAN
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 NCBI Summary for FGF10    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq]
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 UniProt Comments for FGF10    Function: Could be a growth factor active in the process of wound healing. Acts as a mitogen in the lung. May act in a manner similar to FGF-7.

Subunit structure: Interacts with FGFBP1. Ref.7

Subcellular location: Secreted

Potential.

Involvement in disease: Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [

MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections. Ref.9Defects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [

MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. Ref.10 Ref.11

Sequence similarities: Belongs to the heparin-binding growth factors family.
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 Research Articles on FGF10    1. There was no association among gene FGFR1 rs13317, p. E467K, p. M369I, p. S393S and gene FGF10 rs1448037 and nonsyndromic cleft lip with or without palate in Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FGF10 recombinant proteinPathways associated with FGF10 recombinant protein
 Reference Product  PubMed Publications
 FGFR2 recombinant protein  >132 publications with FGF10 and FGFR2
 POMC recombinant protein  >2 publications with FGF10 and POMC
 Products by Pathway  Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FGFR Ligand Binding And Activation Pathway antibodies  FGFR Ligand Binding And Activation Pathway Diagram
 FGFR1 Ligand Binding And Activation Pathway antibodies  FGFR1 Ligand Binding And Activation Pathway Diagram
 FGFR1b Ligand Binding And Activation Pathway antibodies  FGFR1b Ligand Binding And Activation Pathway Diagram
 FGFR2 Ligand Binding And Activation Pathway antibodies  FGFR2 Ligand Binding And Activation Pathway Diagram
 FGFR2b Ligand Binding And Activation Pathway antibodies  FGFR2b Ligand Binding And Activation Pathway Diagram
 FRS2-mediated Cascade Pathway antibodies  FRS2-mediated Cascade Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Pathway antibodies  IRS-related Events Pathway Diagram
Diseases associated with FGF10 recombinant proteinOrgans/Tissues associated with FGF10 recombinant protein
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >83 publications with FGF10 and Congenital Abnormalities
 Neoplasms Antibodies  >32 publications with FGF10 and Neoplasms
 Craniofacial Abnormalities Antibodies  >26 publications with FGF10 and Craniofacial Abnormalities
 Cleft Palate Antibodies  >19 publications with FGF10 and Cleft Palate
 Limb Deformities, Congenital Antibodies  >18 publications with FGF10 and Limb Deformities, Congenital
 Genital Diseases, Male Antibodies  >16 publications with FGF10 and Genital Diseases, Male
 Carcinoma Antibodies  >15 publications with FGF10 and Carcinoma
 Lung Diseases Antibodies  >14 publications with FGF10 and Lung Diseases
 Jaw Abnormalities Antibodies  >14 publications with FGF10 and Jaw Abnormalities
 Inflammation Antibodies  >13 publications with FGF10 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >38 publications with FGF10 and Muscle
 Brain Antibodies  >33 publications with FGF10 and Brain
 Intestine Antibodies  >27 publications with FGF10 and Intestine
 Kidney Antibodies  >20 publications with FGF10 and Kidney
 Trachea Antibodies  >15 publications with FGF10 and Trachea
 Uterus Antibodies  >7 publications with FGF10 and Uterus
 Mixed Antibodies  >4 publications with FGF10 and Mixed
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