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KHK recombinant protein :: Ketohexokinase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203439
SDS-Page
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ketohexokinase (KHK), Recombinant Protein

 Also Known As   

Ketohexokinase, 1-298aa, Human, E Coli

 Product Synonym Names    KHK; Hepatic fructokinase; EC 2.7.1.3; Hepatic fructokinase; ketohexokinase; Ketohexokinase isoform a
 Product Gene Name   

KHK recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTIL SLLGAPCAFM GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDRSLPDV SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV
 OMIM    X78678 mRNA
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) containing 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of KHK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for KHK recombinant protein

   Ketohexokinase is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate, leading to consumption of ATP, formation of AMP. This protein initiates first step in the metabolism of dietary fructose and is an important regulator of hepatic glucose metabolism. It is highly found in liver, renal cortex, and small intestine. Its deficiency causes the benign hereditary metabolic disorder essential fructosuria, leading to fructose being excreted in the urine. Recombinant human Ketohexokinase was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for KHK recombinant protein    Metabolism
 Applications Tested/Suitable for KHK recombinant protein   

SDS-PAGE

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 SDS-Page of KHK recombinant protein    KHK recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for KHK. It may not necessarily be applicable to this product.
 NCBI GI #    13623267
 NCBI GeneID    3795
 NCBI Accession #    AAH06233 [Other Products]
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 UniProt Secondary Accession #    Q6IBK2; Q99532; Q9BRJ3; Q9UMN1 [Other Products]
 UniProt Related Accession #    P50053 [Other Products]
 Molecular Weight    32.7 kDa (298aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    Ketohexokinase (fructokinase)
 NCBI Official Synonym Full Names    ketohexokinase
 NCBI Official Symbol    KHK [Similar Products]
 NCBI Protein Information    ketohexokinase
 UniProt Protein Name    Ketohexokinase
 UniProt Synonym Protein Names   
Hepatic fructokinase
 Protein Family    Ketohexokinase
 UniProt Gene Name    KHK [Similar Products]
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 NCBI Summary for KHK    This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KHK    Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
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Product References and Citations for KHK recombinant protein

   Bonthron DT., et al. (2009) J Histochem Cytochem. 57 (8):763-74.; Schermerhorn T., et al. (2009) Res Vet Sci. 87 (1):115-7. ;
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 Research Articles on KHK    1. Data indicate metabolic enzymes NAD kinase and ketohexokinase as candidate metabolic gene targets, and the chromatin remodeling protein INO80C as a tumor suppressor in KRAS(MUT) colorectal tumor xenograft.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KHK recombinant proteinPathways associated with KHK recombinant protein
 Reference Product  PubMed Publications
 HK1 recombinant protein  >1 publications with KHK and HK1
 ALDOC recombinant protein  >1 publications with KHK and ALDOC
 SORD recombinant protein  >1 publications with KHK and SORD
 Products by Pathway  Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose Catabolism Pathway antibodies  Fructose Catabolism Pathway Diagram
 Fructose Metabolism Pathway antibodies  Fructose Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Polyol Pathway antibodies  Polyol Pathway Diagram
 Sucrose Degradation Pathway antibodies  Sucrose Degradation Pathway Diagram
 Sucrose Degradation V (sucrose Alpha-glucosidase) Pathway antibodies  Sucrose Degradation V (sucrose Alpha-glucosidase) Pathway Diagram
Diseases associated with KHK recombinant proteinOrgans/Tissues associated with KHK recombinant protein
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >12 publications with KHK and Heart Diseases
 Hypertension Antibodies  >9 publications with KHK and Hypertension
 Fatty Liver Antibodies  >5 publications with KHK and Fatty Liver
 Weight Loss Antibodies  >5 publications with KHK and Weight Loss
 Liver Diseases Antibodies  >5 publications with KHK and Liver Diseases
 Hypertrophy Antibodies  >4 publications with KHK and Hypertrophy
 Fructosuria Antibodies  >4 publications with KHK and Fructosuria
 Kidney Diseases Antibodies  >3 publications with KHK and Kidney Diseases
 Liver Neoplasms Antibodies  >2 publications with KHK and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with KHK and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >23 publications with KHK and Liver
 Heart Antibodies  >15 publications with KHK and Heart
 Kidney Antibodies  >8 publications with KHK and Kidney
 Intestine Antibodies  >8 publications with KHK and Intestine
 Muscle Antibodies  >7 publications with KHK and Muscle
 Brain Antibodies  >7 publications with KHK and Brain
 Stomach Antibodies  >3 publications with KHK and Stomach
 Placenta Antibodies  >3 publications with KHK and Placenta
 Lung Antibodies  >2 publications with KHK and Lung
 Uterus Antibodies  >2 publications with KHK and Uterus
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