NP_055034.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted Molecular Mass: 67.9kDa Accurate Molecular Mass: 75kDa as determined by SDS-PAGE reducing conditions.
NCBI Official Full Name
killer cell immunoglobulin-like receptor 2DL2
NCBI Official Synonym Full Names
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
NCBI Protein Information
killer cell immunoglobulin-like receptor 2DL2; NKAT-6; p58 NK receptor CL-43; MHC class I NK cell receptor; CD158 antigen-like family member B1; natural killer-associated transcript 6; p58 natural killer cell receptor clone CL-43
UniProt Protein Name
Killer cell immunoglobulin-like receptor 2DL2
UniProt Synonym Protein Names
CD158 antigen-like family member B1; MHC class I NK cell receptor; Natural killer-associated transcript 6; NKAT-6; p58 natural killer cell receptor clone CL-43
UniProt Synonym Gene Names
UniProt Entry Name
KI2L2_HUMAN
NCBI Summary for KIR2DL2
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
UniProt Comments for KIR2DL2
KIR2DL2: Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: plasma membrane; integral to membrane
Biological Process: regulation of immune response
Research Articles on KIR2DL2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with KIR2DL2 recombinant protein
Diseases associated with KIR2DL2 recombinant protein
Organs/Tissues associated with KIR2DL2 recombinant protein
|