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KIR2DS4 recombinant protein :: Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS949442 KIR2DS4 recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4), Recombinant Protein

 Also Known As   

Recombinant Human Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4)

 Product Synonym Names    Killer cell immunoglobulin-like receptor 2DS4; CD158 antigen-like family member I; MHC class I NK cell receptor; Natural killer-associated transcript 8; NKAT-8; P58 natural killer cell receptor clones CL-39/CL-17; p58 NK receptor CL-39/CL-17; CD_antigen=;
 Product Gene Name   

KIR2DS4 recombinant protein

[Similar Products]
 Product Synonym Gene Name    KIR2DS4; CD158I; KKA3; NKAT8 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    22-245
 Sequence    QEGVHRKPS FLALPGHLVK SEETVILQCW SDVMFEHFLL HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC YGSVPHSPYQ LSAPSDPLDM VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAVRSINGT FQADFPLGPA THGGTYRCFG SFRDAPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLH
 OMIM    604955
 3D Structure    ModBase 3D Structure for P43632
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of KIR2DS4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for KIR2DS4. It may not necessarily be applicable to this product.
 NCBI GI #    530353676
 NCBI GeneID    3809
 NCBI Accession #    NP_001268900.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001281971.1 [Other Products]
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 UniProt Primary Accession #    P43632 [Other Products]
 UniProt Secondary Accession #    Q6H2G7 [Other Products]
 UniProt Related Accession #    P43632 [Other Products]
 Molecular Weight    33,583 Da
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 NCBI Official Full Name    killer cell immunoglobulin-like receptor 2DS4 isoform 2
 NCBI Official Synonym Full Names    killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
 NCBI Official Symbol    KIR2DS4 [Similar Products]
 NCBI Official Synonym Symbols   
KKA3; KIR1D; NKAT8; CD158I; KIR412; NKAT-8; KIR2DS1
[Similar Products]
 NCBI Protein Information    killer cell immunoglobulin-like receptor 2DS4; KIR antigen 2DS4; killer Ig receptor; p58 NK receptor CL-39/CL-17; MHC class I NK cell receptor; killer inhibitory receptor 4-1-2; CD158 antigen-like family member I; natural killer-associated transcript 8; natural killer cell inhibitory receptor; P58 natural killer cell receptor clones CL-39/CL-17; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1
 UniProt Protein Name    Killer cell immunoglobulin-like receptor 2DS4
 UniProt Synonym Protein Names   
CD158 antigen-like family member I; MHC class I NK cell receptor; Natural killer-associated transcript 8; NKAT-8; P58 natural killer cell receptor clones CL-39/CL-17; p58 NK receptor CL-39/CL-17; CD_antigen: CD158i
 Protein Family    Killer cell immunoglobulin-like receptor
 UniProt Gene Name    KIR2DS4 [Similar Products]
 UniProt Synonym Gene Names    CD158I; KKA3; NKAT8; NKAT-8; p58 NK receptor CL-39/CL-17 [Similar Products]
 UniProt Entry Name    KI2S4_HUMAN
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 NCBI Summary for KIR2DS4    Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KIR2DS4    KIR2DS4: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane; plasma membrane

Biological Process: innate immune response
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 Research Articles on KIR2DS4    1. lower genotype frequency in children with systemic juvenile idiopathic arthritis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KIR2DS4 recombinant proteinPathways associated with KIR2DS4 recombinant protein
 Reference Product  PubMed Publications
 HLA-C recombinant protein  >17 publications with KIR2DS4 and HLA-C
 TYROBP recombinant protein  >2 publications with KIR2DS4 and TYROBP
 KLRC1 recombinant protein  >1 publications with KIR2DS4 and KLRC1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
Diseases associated with KIR2DS4 recombinant proteinOrgans/Tissues associated with KIR2DS4 recombinant protein
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >6 publications with KIR2DS4 and Leukemia
 Lymphatic Diseases Antibodies  >2 publications with KIR2DS4 and Lymphatic Diseases
 Leukemia, Myeloid Antibodies  >2 publications with KIR2DS4 and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >2 publications with KIR2DS4 and Leukemia, Myeloid, Acute
 Myelodysplastic Syndromes Antibodies  >1 publications with KIR2DS4 and Myelodysplastic Syndromes
 Epstein-Barr Virus Infections Antibodies  >1 publications with KIR2DS4 and Epstein-Barr Virus Infections
 Carcinoma, Hepatocellular Antibodies  >1 publications with KIR2DS4 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >1 publications with KIR2DS4 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >49 publications with KIR2DS4 and Blood
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