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KIR3DL1 recombinant protein :: Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS948242 KIR3DL1 recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1), Recombinant Protein

 Also Known As   

Recombinant Human Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1)

 Product Synonym Names    Killer cell immunoglobulin-like receptor 3DL1; CD158 antigen-like family member E; HLA-BW4-specific inhibitory NK cell receptor; MHC class I NK cell receptor; Natural killer-associated transcript 3; NKAT-3; p70 natural killer cell receptor clones CL-2/CL-
 Product Gene Name   

KIR3DL1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    KIR3DL1; CD158E; NKAT3; NKB1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    22-340
 Sequence    HMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML YKEDRIHIPI FHGRIFQESF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPVVIMVTGN HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH
 OMIM    604946
 3D Structure    ModBase 3D Structure for P43629
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of KIR3DL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for KIR3DL1. It may not necessarily be applicable to this product.
 NCBI GI #    134268644
 NCBI GeneID    3811
 NCBI Accession #    NP_037421.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_013289.2 [Other Products]
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 UniProt Primary Accession #    P43629 [Other Products]
 UniProt Secondary Accession #    O43473; Q14946; Q16541 [Other Products]
 Molecular Weight    38,403 Da
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 NCBI Official Full Name    killer cell immunoglobulin-like receptor 3DL1
 UniProt Protein Name    Killer cell immunoglobulin-like receptor 3DL1
 UniProt Synonym Protein Names   
CD158 antigen-like family member E; HLA-BW4-specific inhibitory NK cell receptor; MHC class I NK cell receptor; Natural killer-associated transcript 3; NKAT-3; p70 natural killer cell receptor clones CL-2/CL-11; p70 NK receptor CL-2/CL-11; CD_antigen: CD158e
 Protein Family    Killer cell immunoglobulin-like receptor
 UniProt Gene Name    KIR3DL1 [Similar Products]
 UniProt Synonym Gene Names    CD158E; NKAT3; NKB1; NKAT-3; p70 NK receptor CL-2/CL-11 [Similar Products]
 UniProt Entry Name    KI3L1_HUMAN
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 NCBI Summary for KIR3DL1    Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KIR3DL1    KIR3DL1: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: HLA-B specific inhibitory MHC class I receptor activity

Biological Process: regulation of immune response; immune response; signal transduction

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KIR3DL1 recombinant proteinPathways associated with KIR3DL1 recombinant protein
 Reference Product  PubMed Publications
 HLA-C recombinant protein  >35 publications with KIR3DL1 and HLA-C
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram
Diseases associated with KIR3DL1 recombinant proteinOrgans/Tissues associated with KIR3DL1 recombinant protein
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >60 publications with KIR3DL1 and Immune System Diseases
 HIV Infections Antibodies  >36 publications with KIR3DL1 and HIV Infections
 Neoplasms Antibodies  >34 publications with KIR3DL1 and Neoplasms
 Inflammation Antibodies  >6 publications with KIR3DL1 and Inflammation
 Cardiovascular Diseases Antibodies  >6 publications with KIR3DL1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >5 publications with KIR3DL1 and Nervous System Diseases
 Carcinoma Antibodies  >5 publications with KIR3DL1 and Carcinoma
 Liver Diseases Antibodies  >4 publications with KIR3DL1 and Liver Diseases
 Gastrointestinal Diseases Antibodies  >4 publications with KIR3DL1 and Gastrointestinal Diseases
 Skin Neoplasms Antibodies  >3 publications with KIR3DL1 and Skin Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with KIR3DL1 and Liver
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