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SELL recombinant protein :: L-Selectin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142936 SELL recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,995 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

L-Selectin (SELL), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human L-Selectin

 Product Synonym Names    L Selectin Human; L-selectin Human Recombinant; L-selectin; Lymph node homing receptor; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; TQ1; gp90-MEL; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; CD62 antigen-like family member L; CD62L antigen; LAM1; LNHR; LSEL; CD62L; LYAM1; Leu-8; PLNHR; hLHRc; Lyam-1; L-Sel; L-Selectin
 Product Gene Name   

SELL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    153240
 3D Structure    ModBase 3D Structure for P14151
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE. Single band on Western Blot.
 Form/Format    L-Sel is supplied in 1x PBS and 50% Glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 1-2 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of SELL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SELL recombinant protein

   Description: L-Selectin Human Recombinant is expressed in E Coli containing 294 amino acids 39-332 fused to an amino terminal hexahistidine tag, having a total molecular weight of 37.55kDa.

Introduction: L-Selectin belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. The L-Selectin molecule is composed of various domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins.L-selectin is expressed constitutively on lymphocytes, monocytes and granulocytes and interacts specifically with carbohydrate groups on activated endothelial cells. L-Selectin may be shed by proteolytic cleavage and circulating levels in biological fluids may be used as an indicator of various pathological conditions. L-Selectin is cleaved by ADAM17.L-selectin works as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via the high endothelial venules. Ligands present on endothelial cells will attach to leukocytes expressing L-selectin, which causes the leukocytes to become localized at that juncture. The receptor is also located on the cell surfaces of "naive" T cells, which have not yet encountered their particular antigen. This surface expression is lost following the cells activation.
 Product Categories/Family for SELL recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Selectin
 Applications Tested/Suitable for SELL recombinant protein   

Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

 Application Notes for SELL recombinant protein    L-Selectin can be used directly as a positive control in Western blotting, ELISA, immunoprecipitation and other immunological experiments. The biological activity of this product has not yet been tested.
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NCBI/Uniprot data below describe general gene information for SELL. It may not necessarily be applicable to this product.
 NCBI GI #    262206315
 NCBI GeneID    6402
 NCBI Accession #    NP_000646.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000655.4 [Other Products]
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 UniProt Primary Accession #    P14151 [Other Products]
 UniProt Secondary Accession #    P15023; Q9UJ43; B2R6Q8 [Other Products]
 UniProt Related Accession #    P14151 [Other Products]
 Molecular Weight    43,618 Da [Similar Products]
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 NCBI Official Full Name    L-selectin
 NCBI Official Synonym Full Names    selectin L
 NCBI Official Symbol    SELL [Similar Products]
 NCBI Official Synonym Symbols   
TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1
[Similar Products]
 NCBI Protein Information    L-selectin; CD62 antigen-like family member L; gp90-MEL; leukocyte surface antigen Leu-8; leukocyte-endothelial cell adhesion molecule 1; lymph node homing receptor; lymphocyte adhesion molecule 1; pln homing receptor
 UniProt Protein Name    L-selectin
 UniProt Synonym Protein Names   
CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD_antigen: CD62L
 Protein Family    L-selectin
 UniProt Gene Name    SELL [Similar Products]
 UniProt Synonym Gene Names    LNHR; LYAM1; LAM-1; LECAM1 [Similar Products]
 UniProt Entry Name    LYAM1_HUMAN
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 NCBI Summary for SELL    This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
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 UniProt Comments for SELL    SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23-q25

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: heparin binding; protein binding; protease binding; cell adhesion molecule binding; glycosphingolipid binding; carbohydrate binding

Biological Process: regulation of immune response; cell adhesion; blood coagulation; leukocyte migration; response to ATP

Disease: Iga Nephropathy, Susceptibility To, 1
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 Research Articles on SELL    1. Increased expression of L-selectin ligands may be involved in the implantation process in tubal pregnancy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SELL recombinant proteinPathways associated with SELL recombinant protein
 Reference Product  PubMed Publications
 CD44 recombinant protein  >4 publications with SELL and CD44
 CD34 recombinant protein  >4 publications with SELL and CD34
 MSN recombinant protein  >2 publications with SELL and MSN
 SELPLG recombinant protein  >1 publications with SELL and SELPLG
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Diseases associated with SELL recombinant proteinOrgans/Tissues associated with SELL recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >210 publications with SELL and Nervous System Diseases
 Liver Diseases Antibodies  >117 publications with SELL and Liver Diseases
 Inflammation Antibodies  >84 publications with SELL and Inflammation
 Pain Antibodies  >72 publications with SELL and Pain
 Heart Diseases Antibodies  >70 publications with SELL and Heart Diseases
 Gastrointestinal Diseases Antibodies  >61 publications with SELL and Gastrointestinal Diseases
 Carcinoma, Hepatocellular Antibodies  >48 publications with SELL and Carcinoma, Hepatocellular
 Necrosis Antibodies  >46 publications with SELL and Necrosis
 Kidney Diseases Antibodies  >35 publications with SELL and Kidney Diseases
 Fever Antibodies  >29 publications with SELL and Fever
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >590 publications with SELL and Blood
 Liver Antibodies  >189 publications with SELL and Liver
 Bone Antibodies  >176 publications with SELL and Bone
 Muscle Antibodies  >145 publications with SELL and Muscle
 Heart Antibodies  >116 publications with SELL and Heart
 Kidney Antibodies  >98 publications with SELL and Kidney
 Vascular Antibodies  >92 publications with SELL and Vascular
 Brain Antibodies  >90 publications with SELL and Brain
 Lung Antibodies  >81 publications with SELL and Lung
 Spleen Antibodies  >73 publications with SELL and Spleen
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