NP_006005.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,804 Da
NCBI Official Full Name
EKC/KEOPS complex subunit LAGE3
NCBI Official Synonym Full Names
L antigen family member 3
NCBI Official Synonym Symbols
CVG5; ESO3; Pcc1; ITBA2; GAMOS2; DXS9879E; DXS9951E [Similar Products]
NCBI Protein Information
EKC/KEOPS complex subunit LAGE3
UniProt Protein Name
EKC/KEOPS complex subunit LAGE3
UniProt Synonym Protein Names
L antigen family member 3; Protein ESO-3; Protein ITBA2
UniProt Synonym Gene Names
NCBI Summary for LAGE3
This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. [provided by RefSeq, Jul 2008]
UniProt Comments for LAGE3
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex ().
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Products associated with LAGE3 recombinant protein
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