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DCT recombinant protein :: L-dopachrome tautomerase (DCT) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1095393 DCT recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

L-dopachrome tautomerase (DCT), Recombinant Protein

 Also Known As   

Recombinant Chicken L-dopachrome tautomerase (DCT)

 Product Synonym Names    Recombinant L-dopachrome tautomerase (DCT); L-dopachrome tautomerase; DCT; DT EC= 5.3.3.12; L-dopachrome Delta-isomerase Tyrosinase-related protein 2; TRP-2; TRP2
 Product Gene Name   

DCT recombinant protein

[Similar Products]
 Product Synonym Gene Name    DCT; TYRP2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    26-521
 Sequence    QFPRVCMTVE AIRSKRCCPA LGPDPGNVCG VLQGRGWCQG VQVDTQPWSG PYTLRNVDDR ERWPLKFFNQ SCWCTGNFAG YNCGDCKFGW TGPDCSVRKP PVVRKNIHSL TVEEREQFLD VLDRAKTTIH PDYVIATQHW MSLLGPSGEE PQIANCSIYN YFVWLHYYSV RDTLLGPGRP FTAIDFSHQG PAFVTWHRYH LLLLERDLQR LMGNESFALP YWDFATGRNT CDVCTDQLFG APRPDDPGLI SLNSRFSRWQ IVCNSLDDYN RLVTLCNGSD EGLLQRRPRD SGEQLPTAED VRRCLSRHEF DSPPFFRNSS FSFRNALEGF NKPEGALNSP MLNLHNLAHS FLNGTRVLPH AAANDPIFVV LHSFTDAIFD EWMKRFHPPD NAWPEELAPI GHNRLYNMVP FFPPVTNDQL FQTAEQLGYT YAIDLPGSLE ESQAWAAMVG STIGGALIAL AVLVLLLVLF QHRKQRKGFE PLMNVRFSSK KYMEEA
 Chromosome Location    Chromosome: 1; NC_006088.3 (145716157..145736915). Location: chromosome: 1
 3D Structure    ModBase 3D Structure for O93505
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Gallus gallus (Chicken)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of DCT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for DCT. It may not necessarily be applicable to this product.
 NCBI GI #    46048845
 NCBI GeneID    395775
 NCBI Accession #    NP_990266.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_204935.1 [Other Products]
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 UniProt Primary Accession #    O93505 [Other Products]
 UniProt Related Accession #    O93505 [Other Products]
 Molecular Weight    59,314 Da [Similar Products]
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 NCBI Official Full Name    L-dopachrome tautomerase
 NCBI Official Synonym Full Names    dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
 NCBI Official Symbol    DCT [Similar Products]
 NCBI Official Synonym Symbols   
TYRP2
[Similar Products]
 NCBI Protein Information    L-dopachrome tautomerase; DT; TRP2; TRP-2; L-dopachrome Delta-isomerase; tyrosinase-related protein 2; tyrosinase-related protein-2
 UniProt Protein Name    L-dopachrome tautomerase
 UniProt Synonym Protein Names   
L-dopachrome Delta-isomerase; Tyrosinase-related protein 2
 Protein Family    L-dopachrome tautomerase
 UniProt Gene Name    DCT [Similar Products]
 UniProt Synonym Gene Names    TYRP2; DCT; DT; TRP-2; TRP2 [Similar Products]
 UniProt Entry Name    TYRP2_CHICK
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 UniProt Comments for DCT    Function: Involved in regulating eumelanin and phaeomelanin levels.

Catalytic activity: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

Cofactor: Binds 2 zinc ions per subunit

By similarity.

Pathway: Pigment biosynthesis; melanin biosynthesis.

Subunit structure: Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex

By similarity.

Subcellular location: Melanosome membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Melanocytes and retinal pigmented epithelium.

Sequence similarities: Belongs to the tyrosinase family.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with DCT recombinant proteinDiseases associated with DCT recombinant protein
 Products by Pathway  Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >128 publications with DCT and Neoplasms
 Cardiovascular Diseases Antibodies  >84 publications with DCT and Cardiovascular Diseases
 Hypertension Antibodies  >61 publications with DCT and Hypertension
 Nervous System Diseases Antibodies  >59 publications with DCT and Nervous System Diseases
 Melanoma Antibodies  >53 publications with DCT and Melanoma
 Kidney Diseases Antibodies  >42 publications with DCT and Kidney Diseases
 Carcinoma Antibodies  >42 publications with DCT and Carcinoma
 Heart Diseases Antibodies  >39 publications with DCT and Heart Diseases
 Disease Models, Animal Antibodies  >38 publications with DCT and Disease Models, Animal
 Skin Diseases Antibodies  >31 publications with DCT and Skin Diseases
Organs/Tissues associated with DCT recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >23 publications with DCT and Liver
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