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LDHB recombinant protein :: L-lactate dehydrogenase B chain Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717399
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

L-lactate dehydrogenase B chain (LDHB), Recombinant Protein

 Also Known As   

Recombinant Human L-lactate dehydrogenase B chain

 Product Synonym Names    LDH heart subunit; LDH-H; Renal carcinoma antigen NY-REN-46
 Product Gene Name   

LDHB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-334aa; Full Length
 Sequence    ATLKEKLIAP VAEEEATVPN NKITVVGVGQ VGMACAISIL GKSLADELAL VDVLEDKLKG EMMDLQHGSL FLQTPKIVAD KDYSVTANSK IVVVTAGVRQ QEGESRLNLV QRNVNVFKFI IPQIVKYSPD CIIIVVSNPV DILTYVTWKL SGLPKHRVIG SGCNLDSARF RYLMAEKLGI HPSSCHGWIL GEHGDSSVAV WSGVNVAGVS LQELNPEMGT DNDSENWKEV HKMVVESAYE VIKLKGYTNW AIGLSVADLI ESMLKNLSRI HPVSTMVKGM YGIENEVFLS LPCILNARGL TSVINQKLKD DEVAQLKKSA DTLWDIQKDL KDL
 OMIM    150100
 3D Structure    ModBase 3D Structure for P07195
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of LDHB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for LDHB recombinant protein    Metabolism
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 SDS-PAGE of LDHB recombinant protein    LDHB recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for LDHB. It may not necessarily be applicable to this product.
 NCBI GI #    291575128
 NCBI GeneID    3945
 NCBI Accession #    NP_001167568.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001174097.2 [Other Products]
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 UniProt Primary Accession #    P07195 [Other Products]
 UniProt Related Accession #    P07195 [Other Products]
 Molecular Weight    40.6kD
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 NCBI Official Full Name    L-lactate dehydrogenase B chain isoform LDHB
 NCBI Official Synonym Full Names    lactate dehydrogenase B
 NCBI Official Symbol    LDHB [Similar Products]
 NCBI Official Synonym Symbols   
LDH-B; LDH-H; LDHBD; TRG-5; HEL-S-281
[Similar Products]
 NCBI Protein Information    L-lactate dehydrogenase B chain
 UniProt Protein Name    L-lactate dehydrogenase B chain
 UniProt Synonym Protein Names   
LDH heart subunit; LDH-H; Renal carcinoma antigen NY-REN-46
 Protein Family    L-lactate dehydrogenase
 UniProt Gene Name    LDHB [Similar Products]
 UniProt Synonym Gene Names    LDH-B; LDH-H [Similar Products]
 UniProt Entry Name    LDHB_HUMAN
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 NCBI Summary for LDHB    This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Recent studies have shown that two protein isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism, and that these C-terminally distinct isoforms have different subcellular localization. Alternatively spliced transcript variants have also been found for this gene. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Oct 2015]
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Product References and Citations for LDHB recombinant protein

   Structure of the human lactate dehydrogenase B gene.Takeno T., Li S.S.-L.Biochem. J. 257:921-924(1989) The cDNA and protein sequences of human lactate dehydrogenase B.Sakai I., Sharief F.S., Pan Y.-C.E., Li S.S.-L.Biochem. J. 248:933-936(1987) Bienvenut W.V.Submitted (MAY-2005) to UniProtKB Lubec G., Vishwanath V., Chen W.-Q., Sun Y.Submitted (DEC-2008) to UniProtKB Antigens recognized by autologous antibody in patients with renal-cell carcinoma.Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J.3.0.CO;2-5>Int. J. Cancer 83:456-464(1999) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.Nat. Biotechnol. 23:94-101(2005) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.Sci. Signal. 2:RA46-RA46(2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions.Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.Science 325:834-840(2009) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.Sci. Signal. 3:RA3-RA3(2010) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.Read J.A., Winter V.J., Eszes C.M., Sessions R.B., Brady R.L.3.0.CO;2-%23>Proteins 43:175-185(2001) Analysis of a genetic mutation in an electrophoretic variant of the human lactate dehydrogenase-B(H) subunit.Maekawa M., Sudo K., Kitajima M., Matsuura Y., Li S.S.-L., Kanno T.Hum. Genet. 91:423-426(1993) Detection and characterization of new genetic mutations in individuals heterozygous for lactate dehydrogenase-B(H) deficiency using DNA conformation polymorphism analysis and silver staining.Maekawa M., Sudo K., Kitajima M., Matsuura Y., Li S.S.-L., Kanno T.Hum. Genet. 91:163-168(1993) Molecular characterization of genetic mutations in human lactate dehydrogenase (LDH) B (H) variant.Sudo K., Maekawa M., Tomonaga A., Tsukada T., Nakayama T., Kitamura M., Li S.S.-L., Kanno T., Toriumi J.Hum. Genet. 89:158-162(1992) A missense mutation found in human lactate dehydrogenase-B (H) variant gene.Sudo K., Maekawa M., Ikawa S., Machida K., Kitamura M., Li S.S.-L.Biochem. Biophys. Res. Commun. 168:672-676(1990) DNA analysis of slow type of electrophoretic lactate dehydrogenase B(H) variant.Maekawa M., Sudo K., Fujita K., Yoshioka N., Sakurabayashi I., Li S.S.-L., Kanno T.Seibutsu Butsuri Kagaku 38:25-29(1994) Arginine to tryptophan substitution in the active site of a human lactate dehydrogenase variant -- LDHB GUA1 postulated effects on subunit structure and catalysis.Shonnard G.C., Hud N.V., Mohrenweiser H.W.Biochim. Biophys. Acta 1315:9-14(1996) A novel in-frame deletion mutation in a case of lactate dehydrogenase (LD) H subunit deficiency showing an atypical LD isoenzyme pattern in serum and erythrocytes.Sudo K., Maekawa M., Houki N., Okuda T., Akizuki S., Magara T., Kawano K.Clin. Biochem. 32:137-141(1999) First case of missense mutation (LDH-H:R171P) in exon 4 of the lactate dehydrogenase gene detected in a Japanese patient.Hidaka K., Ueda N., Hirata I., Watanabe Y., Minatogawa Y., Iuchi I.J. Hum. Genet. 44:69-72(1999) A novel missense mutation in human lactate dehydrogenase b-subunit gene.Takatani T., Takaoka N., Tatsumi M., Kawamoto H., Okuno Y., Morita K., Masutani T., Murakawa K., Okamoto Y.Mol. Genet. Metab. 73:344-348(2001)
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 Research Articles on LDHB    1. The readthrough-extended lactate dehydrogenase subunit LDHBx can also co-import LDHA, the other LDH subunit, into peroxisomes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LDHB recombinant proteinDiseases associated with LDHB recombinant protein
 Reference Product  PubMed Publications
 GPI recombinant protein  >11 publications with LDHB and GPI
 ME1 recombinant protein  >6 publications with LDHB and ME1
 GOT1 recombinant protein  >3 publications with LDHB and GOT1
 PKM recombinant protein  >2 publications with LDHB and PKM
 PDHB recombinant protein  >1 publications with LDHB and PDHB
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with LDHB and Nervous System Diseases
 Breast Neoplasms Antibodies  >6 publications with LDHB and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >5 publications with LDHB and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >4 publications with LDHB and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >4 publications with LDHB and Cardiovascular Diseases
 Liver Diseases Antibodies  >4 publications with LDHB and Liver Diseases
 Necrosis Antibodies  >3 publications with LDHB and Necrosis
 Heart Diseases Antibodies  >3 publications with LDHB and Heart Diseases
 Lung Neoplasms Antibodies  >3 publications with LDHB and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with LDHB and Neoplasms, Experimental
Organs/Tissues associated with LDHB recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with LDHB and Blood
 Muscle Antibodies  >14 publications with LDHB and Muscle
 Heart Antibodies  >11 publications with LDHB and Heart
 Brain Antibodies  >11 publications with LDHB and Brain
 Testis Antibodies  >10 publications with LDHB and Testis
 Liver Antibodies  >7 publications with LDHB and Liver
 Lymph Node Antibodies  >6 publications with LDHB and Lymph Node
 Lymph Antibodies  >6 publications with LDHB and Lymph
 Adipose Tissue Antibodies  >5 publications with LDHB and Adipose Tissue
 Bone Antibodies  >5 publications with LDHB and Bone
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