Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow LAG3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • FABP4 Antibody
 • MS2-ADAM8-CD156 Antibody
 • Myosin Heavy Chain 8, Skeletal Muscle, Perinatal (MYH8) ELISA Kit
 • IL-1 BETA (IL1B) Antibody
 • Collagen Type VIII Alpha 1 (COL8a1) Recombinant Protein
 • tumor protein, translationally-controlled 1 (TPT1) ELISA Kit
 • INS ELISA Kit
 • ARHGDIA Recombinant Protein
 • Jacalin Protein
 • Poly ADP Ribose Polymerase (PARP) ELISA Kit
 • prohibitin 2 (PHB2) ELISA Kit
 • Eosinophil peroxidase (EPX) ELISA Kit
 • TRIP4 Antibody
 • Interleukin-3 (rIL 3 ) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

LAG3 recombinant protein :: LAG3 / CD223 / Lymphocyte activation gene 3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2545158
SDS-PAGE
Unit / Price
0.05 mg  /  $475 +1 FREE 8GB USB
0.2 mg  /  $1,150 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LAG3 / CD223 / Lymphocyte activation gene 3, Recombinant Protein

★Popular Item★
 Also Known As   

Human LAG3 / CD223 / Lymphocyte activation gene 3 Protein (Fc Tag)

 Product Synonym Names    FDC
 Product Gene Name   

LAG3 recombinant protein

[Similar Products]
 Product Synonym Gene Name    CD223 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    X51985 mRNA
 3D Structure    ModBase 3D Structure for P18627
Section Bar
 Host    Human Cells
Section Bar
 Purity/Purification    > (3.0+91.0+3.1) % as determined by SDS-PAGE.
 Form/Format    Lyophilized from sterile PBS, pH 7.4
Section Bar
 Predicted N Terminal    Val 29
 Endotoxin    <1.0 EU per mug protein as determined by the LAL method.
Section Bar
 Preparation and Storage    Samples are stable for up to twelve months from date of receipt at -70 degree C
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of LAG3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for LAG3 recombinant protein

   Background: LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.

Description: A DNA sequence encoding the human LAG3 (NP_002277.4) (Met1-Leu450) was expressed with the Fc region of human IgG1 at the C-terminus.
 Application Notes for LAG3 recombinant protein    The recombinant human LAG3 consists 660 amino acids and predicts a molecular mass of 72.3 kDa.
Section Bar
 SDS-PAGE of LAG3 recombinant protein    LAG3 recombinant protein SDS-PAGE image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for LAG3. It may not necessarily be applicable to this product.
 NCBI GI #    167614500
 NCBI GeneID    3902
 NCBI Accession #    NP_002277.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_002286.5 [Other Products]
Section Bar
 UniProt Primary Accession #    P18627 [Other Products]
 UniProt Secondary Accession #    Q7Z643; A8K7T9 [Other Products]
 UniProt Related Accession #    P18627 [Other Products]
 Molecular Weight    39,103 Da
Table BarTOPTable Bar
 NCBI Official Full Name    lymphocyte activation gene 3 protein
 NCBI Official Synonym Full Names    lymphocyte activating 3
 NCBI Official Symbol    LAG3 [Similar Products]
 NCBI Official Synonym Symbols   
CD223
[Similar Products]
 NCBI Protein Information    lymphocyte activation gene 3 protein
 UniProt Protein Name    Lymphocyte activation gene 3 protein
 UniProt Synonym Protein Names   
Protein FDC; CD_antigen: CD223
 Protein Family    Lymphocyte activation gene 3 protein
 UniProt Gene Name    LAG3 [Similar Products]
 UniProt Synonym Gene Names    FDC; LAG-3 [Similar Products]
Section Bar
 NCBI Summary for LAG3    Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for LAG3    LAG3: a cell surface receptor involved in lymphocyte activation and neural function. LAG3 expressed on neurons is a receptor that binds extracellular Alpha-synuclein fibrils (PFF) with high affinity, leading to its endocytosis. LAG3 facilitates the neuron-to-neuron spread of PFF and its associated neural toxicity. Binds to HLA class-II antigens. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Molecular Function: antigen binding; MHC class II protein binding
Table BarTOPTable Bar
 Research Articles on LAG3    1. An IL-27/Lag3 axis enhances Foxp3+ regulatory T cell-suppressive function and therapeutic efficacy.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with LAG3 recombinant proteinDiseases associated with LAG3 recombinant protein
 Reference Product  PubMed Publications
 CD4 recombinant protein  >30 publications with LAG3 and CD4
 FOXP3 recombinant protein  >19 publications with LAG3 and FOXP3
 CTLA4 recombinant protein  >10 publications with LAG3 and CTLA4
 PDCD1 recombinant protein  >3 publications with LAG3 and PDCD1
 GZMB recombinant protein  >2 publications with LAG3 and GZMB
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >10 publications with LAG3 and Inflammation
 Disease Models, Animal Antibodies  >7 publications with LAG3 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >3 publications with LAG3 and Neoplasms, Experimental
 Lymphoma Antibodies  >3 publications with LAG3 and Lymphoma
 Necrosis Antibodies  >3 publications with LAG3 and Necrosis
 Immunologic Deficiency Syndromes Antibodies  >2 publications with LAG3 and Immunologic Deficiency Syndromes
 Lung Neoplasms Antibodies  >2 publications with LAG3 and Lung Neoplasms
 Carcinoma Antibodies  >1 publications with LAG3 and Carcinoma
 Heart Diseases Antibodies  >1 publications with LAG3 and Heart Diseases
 Carcinoma, Squamous Cell Antibodies  >1 publications with LAG3 and Carcinoma, Squamous Cell
Organs/Tissues associated with LAG3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >48 publications with LAG3 and Blood
 Spleen Antibodies  >7 publications with LAG3 and Spleen
 Intestine Antibodies  >2 publications with LAG3 and Intestine
 Uterus Antibodies  >1 publications with LAG3 and Uterus
 Brain Antibodies  >1 publications with LAG3 and Brain
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions