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LMX1B recombinant protein :: LIM Homeobox Transcription Factor 1 Beta Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS145561 LMX1B recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LIM Homeobox Transcription Factor 1 Beta (LMX1B), Recombinant Protein

 Also Known As   

Recombinant Human LIM Homeobox Transcription Factor 1, Beta

 Product Gene Name   

LMX1B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    161200
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 Other Notes    Small volumes of LMX1B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for LMX1B recombinant protein    RECOMBINANT & NATURAL PROTEINS
NCBI/Uniprot data below describe general gene information for LMX1B. It may not necessarily be applicable to this product.
 NCBI GI #    485956425
 NCBI GeneID    4010
 NCBI Accession #    O60663.3 [Other Products]
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 UniProt Secondary Accession #    O75463; Q5JU95; Q6ISC9; F8W7W6 [Other Products]
 UniProt Related Accession #    O60663 [Other Products]
 Molecular Weight    45,080 Da
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 NCBI Official Full Name    LIM homeobox transcription factor 1-beta
 NCBI Official Synonym Full Names    LIM homeobox transcription factor 1, beta
 NCBI Official Symbol    LMX1B [Similar Products]
 NCBI Official Synonym Symbols   
NPS1; LMX1.2
[Similar Products]
 NCBI Protein Information    LIM homeobox transcription factor 1-beta; LIM/homeobox protein 1.2; LIM/homeobox protein LMX1B; LMX-1.2
 UniProt Protein Name    LIM homeobox transcription factor 1-beta
 UniProt Synonym Protein Names   
LIM/homeobox protein 1.2; LMX-1.2; LIM/homeobox protein LMX1B
 Protein Family    LIM/homeobox protein
 UniProt Gene Name    LMX1B [Similar Products]
 UniProt Synonym Gene Names    LMX-1.2 [Similar Products]
 UniProt Entry Name    LMX1B_HUMAN
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 NCBI Summary for LMX1B    This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
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 UniProt Comments for LMX1B    LMX1B: Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Defects in LMX1B are the cause of nail-patella syndrome (NPS); also known as onychoosteodysplasia. NPS is a disease that cause abnormal skeletal patterning and renal dysplasia. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Cell development/differentiation; Transcription factor

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: nucleus

Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding; transcription factor activity

Biological Process: collagen fibril organization; transcription, DNA-dependent; in utero embryonic development; multicellular organismal development; neuron migration; cerebellum morphogenesis; limb morphogenesis; neuron differentiation; cell proliferation; organ growth; regulation of transcription, DNA-dependent; dorsal/ventral pattern formation; midbrain development; positive regulation of transcription from RNA polymerase II promoter; central nervous system neuron development

Disease: Nail-patella Syndrome
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 Research Articles on LMX1B    1. In a large family with the two disorders with two novel frameshift TSC1 and LMX1B mutations, we describe the phenotypes
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LMX1B recombinant proteinPathways associated with LMX1B recombinant protein
 Reference Product  PubMed Publications
 LDB1 recombinant protein  >8 publications with LMX1B and LDB1
 FEV recombinant protein  >4 publications with LMX1B and FEV
 GBX2 recombinant protein  >3 publications with LMX1B and GBX2
 TCF3 recombinant protein  >2 publications with LMX1B and TCF3
 LRP4 recombinant protein  >1 publications with LMX1B and LRP4
 Products by Pathway  Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with LMX1B recombinant proteinOrgans/Tissues associated with LMX1B recombinant protein
 Disease Name  Pubmed Publications
 Nail-Patella Syndrome Antibodies  >79 publications with LMX1B and Nail-Patella Syndrome
 Kidney Diseases Antibodies  >31 publications with LMX1B and Kidney Diseases
 Proteinuria Antibodies  >14 publications with LMX1B and Proteinuria
 Brain Diseases Antibodies  >13 publications with LMX1B and Brain Diseases
 Pain Antibodies  >12 publications with LMX1B and Pain
 Glaucoma 1, Open Angle, A Antibodies  >8 publications with LMX1B and Glaucoma 1, Open Angle, A
 Mental Disorders Antibodies  >8 publications with LMX1B and Mental Disorders
 Renal Insufficiency Antibodies  >7 publications with LMX1B and Renal Insufficiency
 Hematuria Antibodies  >5 publications with LMX1B and Hematuria
 Edema Antibodies  >3 publications with LMX1B and Edema
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >86 publications with LMX1B and Brain
 Eye Antibodies  >21 publications with LMX1B and Eye
 Mixed Antibodies  >1 publications with LMX1B and Mixed
 Testis Antibodies  >1 publications with LMX1B and Testis
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