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LOX recombinant protein

Scan QR to view Datasheet Catalog #    MBS205887
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LOX, Recombinant Protein

★Popular Item★
 Also Known As   

LOX, 169-417aa, Human, His tag, E Coli (Denatured)

 Product Synonym Names    Protein-lysine 6-oxidase; Lysyl oxidase
 Product Gene Name   

LOX recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSDDPYNPY KYSDDNPYYN YYDTYERPRP GGRYRPGYGT GYFQYGLPDL VADPYYIQAS TYVQKMSMYN LRCAAEENCL ASTAYRADVR DYDHRVLLRF PQRVKNQGTS DFLPSRPRYS WEWHSCHQHY HSMDEFSHYD LLDANTQRRV AEGHKASFCL EDTSCDYGYH RRFACTAHTQ GLSPGCYDTY GADIDCQWID ITDVKPGNYI LKVSVNPSYL VPESDYTNNV VRCDIRYTGH HAYASGCTIS PY
 OMIM    S78694 mRNA
 3D Structure    ModBase 3D Structure for P28300
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 Host    E Coli
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 Purity/Purification    > 85% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of LOX recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for LOX recombinant protein

   LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. Recombinant human LOX protein, fused to His-tag at N-terminus, was expressed in E Coli.
 Product Categories/Family for LOX recombinant protein    Cytoskeleton
 Applications Tested/Suitable for LOX recombinant protein   

SDS-PAGE

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 SDS-Page of LOX recombinant protein    LOX recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for LOX. It may not necessarily be applicable to this product.
 NCBI GI #    20149540
 NCBI GeneID    4015
 NCBI Accession #    NP_002308 [Other Products]
 NCBI GenBank Nucleotide #    NM_002317.6 [Other Products]
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 UniProt Primary Accession #    P28300 [Other Products]
 UniProt Secondary Accession #    Q5FWF0; B2R5Q3 [Other Products]
 UniProt Related Accession #    P28300 [Other Products]
 Molecular Weight    31.4 kDa (272aa)
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 NCBI Official Full Name    protein-lysine 6-oxidase isoform 1 preproprotein
 NCBI Official Synonym Full Names    lysyl oxidase
 NCBI Official Symbol    LOX [Similar Products]
 NCBI Official Synonym Symbols   
AAT10
[Similar Products]
 NCBI Protein Information    protein-lysine 6-oxidase
 UniProt Protein Name    Protein-lysine 6-oxidase
 UniProt Synonym Protein Names   
Lysyl oxidase
 Protein Family    Linoleate 9/13-lipoxygenase
 UniProt Gene Name    LOX [Similar Products]
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 NCBI Summary for LOX    This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
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 UniProt Comments for LOX    Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture ().
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Product References and Citations for LOX recombinant protein

   Kim Y., et al. (1995) J. Biol. Chem. 270:7176-7182.; Contente S., et al. (1999) Mol. Cell. Biochem. 194:79-91.
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 Research Articles on LOX    1. LOX expression was mildly but significantly upregulated in CD34+-derived primary myelofibrosis megakaryocytes and platelets compared with controls. These megakaryocytes showed a greater tendency to adhere and spread to monomeric collagen, and this was inhibited by the LOX-specific inhibitor BAPN.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LOX recombinant proteinPathways associated with LOX recombinant protein
 Reference Product  PubMed Publications
 LOXL2 recombinant protein  >77 publications with LOX and LOXL2
 LOXL1 recombinant protein  >71 publications with LOX and LOXL1
 BMP1 recombinant protein  >9 publications with LOX and BMP1
 FBLN5 recombinant protein  >8 publications with LOX and FBLN5
 ELN recombinant protein  >5 publications with LOX and ELN
 PCOLCE recombinant protein  >4 publications with LOX and PCOLCE
 Products by Pathway  Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Canonical And Non-Canonical TGF-B Signaling Pathway antibodies  Canonical And Non-Canonical TGF-B Signaling Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Crosslinking Of Collagen Fibrils Pathway antibodies  Crosslinking Of Collagen Fibrils Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with LOX recombinant proteinOrgans/Tissues associated with LOX recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >837 publications with LOX and Inflammation
 Cardiovascular Diseases Antibodies  >751 publications with LOX and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >518 publications with LOX and Disease Models, Animal
 Necrosis Antibodies  >299 publications with LOX and Necrosis
 Heart Diseases Antibodies  >233 publications with LOX and Heart Diseases
 Fibrosis Antibodies  >200 publications with LOX and Fibrosis
 Neoplasms, Experimental Antibodies  >177 publications with LOX and Neoplasms, Experimental
 Hypertension Antibodies  >176 publications with LOX and Hypertension
 Lung Neoplasms Antibodies  >145 publications with LOX and Lung Neoplasms
 Edema Antibodies  >145 publications with LOX and Edema
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >891 publications with LOX and Vascular
 Muscle Antibodies  >484 publications with LOX and Muscle
 Brain Antibodies  >477 publications with LOX and Brain
 Lung Antibodies  >371 publications with LOX and Lung
 Heart Antibodies  >347 publications with LOX and Heart
 Liver Antibodies  >317 publications with LOX and Liver
 Bone Antibodies  >287 publications with LOX and Bone
 Skin Antibodies  >214 publications with LOX and Skin
 Kidney Antibodies  >201 publications with LOX and Kidney
 Embryonic Tissue Antibodies  >180 publications with LOX and Embryonic Tissue
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