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LRPAP1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204340
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LRPAP1, Recombinant Protein

 Also Known As   

LRPAP1, 35-357aa, Human, His tag, E Coli

 Product Synonym Names    alpha-2-macroglobulin receptor-associated protein; A2MRAP; A2RAP; HBP44; MGC138272; MRAP; RAP
 Product Gene Name   

LRPAP1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSHMYSREK NQPKPSPKRE SGEEFRMEKL NQLWEKAQRL HLPPVRLAEL HADLKIQERD ELAWKKLKLD GLDEDGEKEA RLIRNLNVIL AKYGLDGKKD ARQVTSNSLS GTQEDGLDDP RLEKLWHKAK TSGKFSGEEL DKLWREFLHH KEKVHEYNVL LETLSRTEEI HENVISPSDL SDIKGSVLHS RHTELKEKLR SINQGLDRLR RVSHQGYSTE AEFEEPRVID LWDLAQSANL TDKELEAFRE ELKHFEAKIE KHNHYQKQLE IAHEKLRHAE SVGDGERVSR SREKHALLEG RTKELGYTVK KHLQDLSGRI SRARHNEL
 OMIM    M63959 mRNA
 3D Structure    ModBase 3D Structure for P30533
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 1mM DTT
 Concentration    1.0 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of LRPAP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LRPAP1 recombinant protein

   LRPAP1, also known as alpha-2-macroglobulin receptor-associated protein, belongs to the alpha-2-MRAP family. This protein interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. It is present on the cell surface forming a complex with the alpha 2 macroglobulin receptor heavy and light chains In complex with the alpha 2 MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis Recombinant human LRPAP1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for LRPAP1 recombinant protein    Metabolism
 Applications Tested/Suitable for LRPAP1 recombinant protein   

SDS-PAGE

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 SDS-Page of LRPAP1 recombinant protein    LRPAP1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for LRPAP1. It may not necessarily be applicable to this product.
 NCBI GI #    4505021
 NCBI GeneID    4043
 NCBI Accession #    NP_002328 [Other Products]
 NCBI GenBank Nucleotide #    NM_002337.3 [Other Products]
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 UniProt Primary Accession #    P30533 [Other Products]
 UniProt Secondary Accession #    Q2M310; Q53HQ3; Q53HS6; D3DVR9 [Other Products]
 UniProt Related Accession #    P30533 [Other Products]
 Molecular Weight    40.4 kDa (348aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    alpha-2-macroglobulin receptor-associated protein
 NCBI Official Synonym Full Names    LDL receptor related protein associated protein 1
 NCBI Official Symbol    LRPAP1 [Similar Products]
 NCBI Official Synonym Symbols   
RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP
[Similar Products]
 NCBI Protein Information    alpha-2-macroglobulin receptor-associated protein
 UniProt Protein Name    Alpha-2-macroglobulin receptor-associated protein
 UniProt Synonym Protein Names   
Low density lipoprotein receptor-related protein-associated protein 1; RAP
 Protein Family    Alpha-2-macroglobulin receptor-associated protein
 UniProt Gene Name    LRPAP1 [Similar Products]
 UniProt Synonym Gene Names    A2MRAP; Alpha-2-MRAP; RAP [Similar Products]
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 NCBI Summary for LRPAP1    This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
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 UniProt Comments for LRPAP1    Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.
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Product References and Citations for LRPAP1 recombinant protein

   Vash B. et al. (1998) Blood 92: 3277-3285.; Trommsdorff M. et al. (1999) Cell 97: 689-701.
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 Research Articles on LRPAP1    1. data also reveal that D1D2 is able to bind to a second distinct site on LRP1 to form a monovalent complex. The studies confirm the canonical model for ligand recognition by this class of receptors, which is initiated by pairs of lysine residues that dock into acidic pockets on the receptor
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LRPAP1 recombinant proteinPathways associated with LRPAP1 recombinant protein
 Reference Product  PubMed Publications
 VLDLR recombinant protein  >2 publications with LRPAP1 and VLDLR
 LRP2 recombinant protein  >2 publications with LRPAP1 and LRP2
 LRP8 recombinant protein  >1 publications with LRPAP1 and LRP8
 Products by Pathway  Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
 Reelin Signaling Pathway antibodies  Reelin Signaling Pathway Diagram
 Signaling Events Mediated By The Hedgehog Family Pathway antibodies  Signaling Events Mediated By The Hedgehog Family Pathway Diagram
Diseases associated with LRPAP1 recombinant proteinOrgans/Tissues associated with LRPAP1 recombinant protein
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >8 publications with LRPAP1 and Brain Diseases
 Heart Diseases Antibodies  >4 publications with LRPAP1 and Heart Diseases
 Abnormalities, Multiple Antibodies  >2 publications with LRPAP1 and Abnormalities, Multiple
 Neurobehavioral Manifestations Antibodies  >2 publications with LRPAP1 and Neurobehavioral Manifestations
 Prenatal Injuries Antibodies  >2 publications with LRPAP1 and Prenatal Injuries
 Prenatal Exposure Delayed Effects Antibodies  >2 publications with LRPAP1 and Prenatal Exposure Delayed Effects
 Cognition Disorders Antibodies  >1 publications with LRPAP1 and Cognition Disorders
 Weight Loss Antibodies  >1 publications with LRPAP1 and Weight Loss
 Necrosis Antibodies  >1 publications with LRPAP1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with LRPAP1 and Blood
 Liver Antibodies  >4 publications with LRPAP1 and Liver
 Eye Antibodies  >4 publications with LRPAP1 and Eye
 Brain Antibodies  >4 publications with LRPAP1 and Brain
 Kidney Antibodies  >2 publications with LRPAP1 and Kidney
 Nerve Antibodies  >2 publications with LRPAP1 and Nerve
 Bone Antibodies  >2 publications with LRPAP1 and Bone
 Vascular Antibodies  >2 publications with LRPAP1 and Vascular
 Heart Antibodies  >2 publications with LRPAP1 and Heart
 Spleen Antibodies  >2 publications with LRPAP1 and Spleen
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