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LYPLA1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203417
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LYPLA1, Recombinant Protein

★Popular Item★
 Also Known As   

LYPLA1, 1-230aa, Mouse, His tag, E Coli

 Product Synonym Names    Acyl-protein thioesterase 1; lysophospholipase 1; Pla1a; APT-1; LysoPLA I; LPL-I; APT1
 Product Gene Name   

LYPLA1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.1M NaCl,1mM DTT
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Mouse
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of LYPLA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for LYPLA1 recombinant protein

   LYPLA1 is lysophospholipase that acts on biological membranes to regulate the multifunctional lysophospholipids. This protein hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS and also has depalmitoylating activity. Recombinant mouse LYPLA1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques
 Product Categories/Family for LYPLA1 recombinant protein    Metabolism
 Applications Tested/Suitable for LYPLA1 recombinant protein   


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 SDS-PAGE of LYPLA1 recombinant protein    LYPLA1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for LYPLA1. It may not necessarily be applicable to this product.
 NCBI GI #    6678760
 NCBI GeneID    18777
 NCBI Accession #    NP_032892 [Other Products]
 NCBI GenBank Nucleotide #    NM_008866.2 [Other Products]
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 UniProt Secondary Accession #    Q3TJZ0; Q7TPX1; Q8BWM6 [Other Products]
 UniProt Related Accession #    P97823 [Other Products]
 Molecular Weight    26.8 kDa (250aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    acyl-protein thioesterase 1
 NCBI Official Synonym Full Names    lysophospholipase 1
 NCBI Official Symbol    Lypla1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    acyl-protein thioesterase 1; APT-1; LPL-I; lysoPLA I; lysophopholipase 1; lysophospholipase I; phospholipase 1a
 UniProt Protein Name    Acyl-protein thioesterase 1
 UniProt Synonym Protein Names   
Lysophospholipase 1; Lysophospholipase I; LPL-I; LysoPLA I
 UniProt Gene Name    Lypla1 [Similar Products]
 UniProt Synonym Gene Names    Apt1; Pla1a; APT-1; LPL-I; LysoPLA I [Similar Products]
 UniProt Entry Name    LYPA1_MOUSE
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 UniProt Comments for LYPLA1    LYPLA1: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity. Belongs to the AB hydrolase 2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.2.-; Phospholipase; Lipid Metabolism - glycerophospholipid

Cellular Component: mitochondrion; cytoplasm; cytosol

Molecular Function: acyl-CoA hydrolase activity; hydrolase activity; palmitoyl-(protein) hydrolase activity; CoA hydrolase activity; lysophospholipase activity

Biological Process: negative regulation of Golgi to plasma membrane protein transport; lipid metabolic process; fatty acid metabolic process; protein depalmitoylation
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Product References and Citations for LYPLA1 recombinant protein

   Schaloske R.H., et al. (2006) Biochim Biophys Acta. 1761:1246-1259.
Hiraoka M., et al. (2002) J. Biol. Chem 277:10090-10099.
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 Research Articles on LYPLA1    1. Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with LYPLA1 recombinant proteinDiseases associated with LYPLA1 recombinant protein
 Products by Pathway  Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nitric Oxide Pathway antibodies  Metabolism Of Nitric Oxide Pathway Diagram
 ENOS Activation Pathway antibodies  ENOS Activation Pathway Diagram
 ENOS Activation And Regulation Pathway antibodies  ENOS Activation And Regulation Pathway Diagram
 Disease Name  Pubmed Publications
 Weight Gain Antibodies  >1 publications with LYPLA1 and Weight Gain
 Atherosclerosis Antibodies  >1 publications with LYPLA1 and Atherosclerosis
 Neoplasm Metastasis Antibodies  >1 publications with LYPLA1 and Neoplasm Metastasis
 Urinary Bladder Neoplasms Antibodies  >1 publications with LYPLA1 and Urinary Bladder Neoplasms
 Hyperplasia Antibodies  >1 publications with LYPLA1 and Hyperplasia
 Necrosis Antibodies  >1 publications with LYPLA1 and Necrosis
Organs/Tissues associated with LYPLA1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with LYPLA1 and Brain
 Blood Antibodies  >5 publications with LYPLA1 and Blood
 Kidney Antibodies  >3 publications with LYPLA1 and Kidney
 Intestine Antibodies  >1 publications with LYPLA1 and Intestine
 Bladder Antibodies  >1 publications with LYPLA1 and Bladder
 Skin Antibodies  >1 publications with LYPLA1 and Skin
 Thymus Antibodies  >1 publications with LYPLA1 and Thymus
 Ovary Antibodies  >1 publications with LYPLA1 and Ovary
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