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LAMa3 recombinant protein :: Laminin Alpha 3 (LAMa3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2010860 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $255 +1 FREE 8GB USB
0.1 mg  /  $390 +1 FREE 8GB USB
0.2 mg  /  $480 +1 FREE 8GB USB
0.5 mg  /  $935 +1 FREE 8GB USB
1 mg  /  $1,380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Laminin Alpha 3 (LAMa3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Laminin Alpha 3 (LAMa3)

 Product Gene Name   

LAMa3 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Laminin Alpha 3 (LAMa3) (MBS2001626)
Antigen: Laminin Alpha 3 (LAMa3) (MBS2010860)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2010860 Technical Datasheet    Technical Datasheet PDF
 Chromosome Location    Chromosome: 18; NC_000018.9 (21269562..21535030). Location: 18q11.2
 OMIM    226700
 3D Structure    ModBase 3D Structure for Q16787
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 Host    E. coli
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 Purity/Purification    >90%
 Concentration    Original Concentration: 200g/mL (lot specific)
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 Source    Prokaryotic expression
 Residues    Gln47~Leu296
 Tags    N-terminal His-Tag
 Subcellular Location    Secreted, extracellular matrix.
 Traits    Freeze-dried powder
 Predicted isoelectric point    5.9
 Predicted Molecular Mass    28.3kDa
 Accurate Molecular Mass    33kDa as determined by SDS-PAGE reducing conditions.
 Phenomenon explanation    The possible reasons that the actual band size differs from the predicted are as follows:
1. Splice variants: Alternative splicing may create different sized proteins from the same gene.
2. Relative charge: The composition of amino acids may affects the charge of the protein.
3. Post-translational modification: Phosphorylation, glycosylation, methylation etc.
4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form.
5. Polymerization of the target protein: Dimerization, multimerization etc.
 Usage    Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex
    
 Organism species    Homo Sapiens (Human)
 Buffer formulation    20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 12 months.

Stability Test:The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of LAMa3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for LAMa3 recombinant protein   

Positive Control, Immunogen, SDS-PAGE, WB

(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of LAMa3 recombinant protein    LAMa3 recombinant protein Sequence image
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 SDS-PAGE of LAMa3 recombinant protein    LAMa3 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for LAMa3. It may not necessarily be applicable to this product.
 NCBI GI #    38045908
 NCBI GeneID    3909
 NCBI Accession #    NP_000218.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000227.3 [Other Products]
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 UniProt Primary Accession #    Q16787 [Other Products]
 UniProt Secondary Accession #    Q13679; Q13680; Q6VU67; Q6VU68; Q6VU69; Q76E14; Q96TG0 [Other Products]
 UniProt Related Accession #    Q16787 [Other Products]
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 NCBI Official Full Name    laminin subunit alpha-3 isoform 2
 NCBI Official Synonym Full Names    laminin, alpha 3
 NCBI Official Symbol    LAMA3 [Similar Products]
 NCBI Official Synonym Symbols   
E170; LOCS; BM600; LAMNA; lama3a
[Similar Products]
 NCBI Protein Information    laminin subunit alpha-3; BM600 150kD subunit; nicein 150kD subunit; nicein subunit alpha; kalinin 165kD subunit; kalinin subunit alpha; epiligrin subunit alpha; laminin-5 alpha 3 chain; laminin-5 subunit alpha; laminin-6 subunit alpha; laminin-7 subunit alpha; epiligrin 170 kda subunit; epiligrin alpha 3 subunit; laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin)
 UniProt Protein Name    Laminin subunit alpha-3
 UniProt Synonym Protein Names   
Epiligrin 170 kDa subunit; E170; Epiligrin subunit alpha; Kalinin subunit alpha; Laminin-5 subunit alpha; Laminin-6 subunit alpha; Laminin-7 subunit alpha; Nicein subunit alpha
 Protein Family    Laminin
 UniProt Gene Name    LAMA3 [Similar Products]
 UniProt Synonym Gene Names    LAMNA; E170 [Similar Products]
 UniProt Entry Name    LAMA3_HUMAN
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 NCBI Summary for LAMa3    The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]
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 UniProt Comments for LAMa3    LAMA3: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMA3 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB); also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. Defects in LAMA3 are the cause of laryngoonychocutaneous syndrome (LOCS). LOCS is an autosomal recessive epithelial disorder confined to the Punjabi Muslim population. The condition is characterized by cutaneous erosions, nail dystrophy and exuberant vascular granulation tissue in certain epithelia, especially conjunctiva and larynx. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: laminin-5 complex; laminin-1 complex; extracellular region; basement membrane

Molecular Function: structural molecule activity; receptor binding

Biological Process: regulation of cell adhesion; extracellular matrix disassembly; hemidesmosome assembly; epidermis development; extracellular matrix organization and biogenesis; regulation of embryonic development; cell adhesion; regulation of cell migration

Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Laryngoonychocutaneous Syndrome; Epidermolysis Bullosa, Junctional, Herlitz Type
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 Research Articles on LAMa3    1. Results identify the point during neoplastic progression in epithelia when the tumor suppressor p16 and laminin 5 are expressed and suggest that normal epithelia may use the same mechanism to generate non-dividing, motile cells for wound repair.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LAMa3 recombinant proteinPathways associated with LAMa3 recombinant protein
 Reference Product  PubMed Publications
 LAMB3 recombinant protein  >51 publications with LAMa3 and LAMB3
 LAMC2 recombinant protein  >49 publications with LAMa3 and LAMC2
 ITGB4 recombinant protein  >5 publications with LAMa3 and ITGB4
 LAMB1 recombinant protein  >2 publications with LAMa3 and LAMB1
 ITGA3 recombinant protein  >1 publications with LAMa3 and ITGA3
 LAMB2 recombinant protein  >1 publications with LAMa3 and LAMB2
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Anchoring Fibril Formation Pathway antibodies  Anchoring Fibril Formation Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
Diseases associated with LAMa3 recombinant proteinOrgans/Tissues associated with LAMa3 recombinant protein
 Disease Name  Pubmed Publications
 Epidermolysis Bullosa, Junctional Antibodies  >55 publications with LAMa3 and Epidermolysis Bullosa, Junctional
 Neoplasms Antibodies  >18 publications with LAMa3 and Neoplasms
 Carcinoma Antibodies  >17 publications with LAMa3 and Carcinoma
 Neoplasm Metastasis Antibodies  >5 publications with LAMa3 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >5 publications with LAMa3 and Adenocarcinoma
 Necrosis Antibodies  >3 publications with LAMa3 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >3 publications with LAMa3 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >3 publications with LAMa3 and Inflammation
 Laryngo onycho cutaneous syndrome Antibodies  >3 publications with LAMa3 and Laryngo onycho cutaneous syndrome
 Lung Neoplasms Antibodies  >2 publications with LAMa3 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >49 publications with LAMa3 and Skin
 Lung Antibodies  >5 publications with LAMa3 and Lung
 Bone Antibodies  >4 publications with LAMa3 and Bone
 Kidney Antibodies  >4 publications with LAMa3 and Kidney
 Muscle Antibodies  >4 publications with LAMa3 and Muscle
 Mouth Antibodies  >4 publications with LAMa3 and Mouth
 Liver Antibodies  >3 publications with LAMa3 and Liver
 Placenta Antibodies  >3 publications with LAMa3 and Placenta
 Embryonic Tissue Antibodies  >2 publications with LAMa3 and Embryonic Tissue
 Connective Tissue Antibodies  >2 publications with LAMa3 and Connective Tissue
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