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S recombinant protein :: Large envelope protein (S) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1211330
SDS-PAGE
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 Product Name   

Large envelope protein (S), Recombinant Protein

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 Also Known As   

Recombinant Hepatitis B virus genotype B2 Large envelope protein (S)

 Product Synonym Names    Recombinant Large envelope protein (S); Large envelope protein; L glycoprotein L-HBsAg; LHB Large S protein Large surface protein Major surface antigen
 Product Gene Name   

S recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-389
 Sequence    GTNLSVPNPL GFFPDHQLDP AFKANSDNPD WDLNPHKDNW PDSNKVGVGA FGPGFTPPHG GLLGWSPQAQ GILTTVPTAP PPASTNRQLG RKPTPLSPPL RDTHPQAMQW NSTTFHQTLQ DPRVRALYFP AGGSSSGTVN PVQNTASSIS SILSTTGDPV PNMENIASGL LGPLLVLQAG FFSLTKILTI PLSLDSWWTS LNFLGETPVC LGQNSQSQIS SHSPTCCPPI CPGYRWMCLR RFIIFLCILL LCLIFLLVLL DYQGMLPVCP LIPGSSTTST GPCKTCTTPA QGTSMFPSCC CTKPTDGNCT CIPIPSSWAF AKYLWEWASV RFSWLSLLVP FVQWFVGLSP TVWLSVIWMM WFWGPSLYNI LSPFMPLLPI FFCLWVYI
 3D Structure    ModBase 3D Structure for P17397
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90%(SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 Degree C for up to one week.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of S recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for S recombinant protein

   The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein (By similarity).
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 SDS-PAGE of S recombinant protein    S recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for S. It may not necessarily be applicable to this product.
 NCBI GI #    138793
 NCBI Accession #    P17397.3 [Other Products]
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 UniProt Primary Accession #    P17397 [Other Products]
 Molecular Weight    58kD [Similar Products]
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 NCBI Official Full Name    Large envelope protein
 UniProt Protein Name    Large envelope protein
 UniProt Synonym Protein Names   
L glycoprotein; L-HBsAg; LHB; Large S protein; Large surface protein; Major surface antigen
 UniProt Gene Name    S [Similar Products]
 UniProt Synonym Gene Names    LHB [Similar Products]
 UniProt Entry Name    HBSAG_HBVB2
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 UniProt Comments for S    Function: The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane

Probable. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein

By similarity.The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid

By similarity.

Subunit structure: Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion

By similarity.

Subcellular location: Virion membrane

By similarity.

Domain: The large envelope protein is synthesized with the pre-S region at the cytosolic side of the endoplasmic reticulum and, hence will be within the virion after budding. Therefore the pre-S region is not N-glycosylated. Later a post-translational translocation of N-terminal pre-S and TM1 domains occur in about 50% of proteins at the virion surface. These molecules change their topology by an unknown mechanism, resulting in exposure of pre-S region at virion surface. For isoform M in contrast, the pre-S2 region is translocated cotranslationally to the endoplasmic reticulum lumen and is N-glycosylated.

Post-translational modification: Isoform M is N-terminally acetylated at a ratio of 90%, and N-glycosylated at the pre-S2 region

By similarity.Myristoylated

By similarity.

Biotechnological use: Systematic vaccination of individuals at risk of exposure to the virus has been the main method of controlling the morbidity and mortality associated with hepatitis B. The first hepatitis B vaccine was manufactured by the purification and inactivation of HBsAg obtained from the plasma of chronic hepatitis B virus carriers. The vaccine is now produced by recombinant DNA techniques and expression of the S isoform in yeast cells. The pre-S region do not seem to induce strong enough antigenic response.

Sequence similarities: Belongs to the orthohepadnavirus major surface antigen family.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with S recombinant proteinPathways associated with S recombinant protein
 Reference Product  PubMed Publications
 FLNA recombinant protein  >12 publications with S and FLNA
 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
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 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
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