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LXN recombinant protein :: Latexin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203268
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Latexin (LXN), Recombinant Protein

 Also Known As   

Latexin, 1-222aa, Human, Recombinant, E Coli

 Product Synonym Names    LXN; ECI; TCI; MuM; Endogenous carboxypeptidase inhibitor; Latexin; Latexin protein; Tissue carboxypeptidase inhibitor
 Product Gene Name   

LXN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 50mM NaCl, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Expression System    E Coli
 Endotoxin    < 1.0 Eu per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of LXN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for LXN recombinant protein

   Latexin, a carboxypeptidase A inhibitor, is highly expressed in heart, prostate, ovary, kidney, pancrease, and colon, moderaqte or low in other tissues including brain. Latexin has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1. It is down-regulated in the presenilin-1-deficient mouse brain, thus putatively playing a role in Alzheimer's disease. Recombinant human Latexin protein was expressed in E.coli and purified by using conventional chromatography.
 Product Categories/Family for LXN recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for LXN recombinant protein   


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 SDS-PAGE of LXN recombinant protein    LXN recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for LXN. It may not necessarily be applicable to this product.
 NCBI GI #    194473714
 NCBI GeneID    56925
 NCBI Accession #    NP_064554 [Other Products]
 NCBI GenBank Nucleotide #    NM_020169.3 [Other Products]
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 UniProt Secondary Accession #    Q96PN2; Q9NQS6 [Other Products]
 UniProt Related Accession #    Q9BS40 [Other Products]
 Molecular Weight    25.7 kDa (222aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    latexin
 NCBI Official Synonym Full Names    latexin
 NCBI Official Symbol    LXN [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    latexin; MUM; endogenous carboxypeptidase inhibitor; tissue carboxypeptidase inhibitor
 UniProt Protein Name    Latexin
 UniProt Synonym Protein Names   
Endogenous carboxypeptidase inhibitor; ECI; Protein MUM; Tissue carboxypeptidase inhibitor; TCI
 Protein Family    Latexin
 UniProt Gene Name    LXN [Similar Products]
 UniProt Synonym Gene Names    ECI; TCI [Similar Products]
 UniProt Entry Name    LXN_HUMAN
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 NCBI Summary for LXN    This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]
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 UniProt Comments for LXN    LXN: Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. Belongs to the protease inhibitor I47 (latexin) family.

Chromosomal Location of Human Ortholog: 3q25.32

Cellular Component: cytoplasm

Molecular Function: heparin binding; metalloendopeptidase inhibitor activity

Biological Process: inflammatory response; detection of temperature stimulus involved in sensory perception of pain
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Product References and Citations for LXN recombinant protein

   De Haan G., et al. (2007). Nat Genet. 39(2):141-2
Aagaard A., et al. (2005). Structure. 13(2):309-17
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 Research Articles on LXN    1. latexin is markedly downregulated in hepatocellular carcinoma specimens, compared to adjacent non-cancerous tissues.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LXN recombinant proteinDiseases associated with LXN recombinant protein
 Reference Product  PubMed Publications
 CPA1 recombinant protein  >1 publications with LXN and CPA1
 CPA2 recombinant protein  >1 publications with LXN and CPA2
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >3 publications with LXN and Carcinoma
 Disease Models, Animal Antibodies  >2 publications with LXN and Disease Models, Animal
 Necrosis Antibodies  >2 publications with LXN and Necrosis
 Melanoma Antibodies  >2 publications with LXN and Melanoma
 Pain Antibodies  >1 publications with LXN and Pain
 Nervous System Diseases Antibodies  >1 publications with LXN and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >1 publications with LXN and Neoplasms, Experimental
Organs/Tissues associated with LXN recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with LXN and Brain
 Prostate Antibodies  >3 publications with LXN and Prostate
 Pancreas Antibodies  >2 publications with LXN and Pancreas
 Skin Antibodies  >2 publications with LXN and Skin
 Blood Antibodies  >2 publications with LXN and Blood
 Bone Antibodies  >1 publications with LXN and Bone
 Nerve Antibodies  >1 publications with LXN and Nerve
 Stomach Antibodies  >1 publications with LXN and Stomach
 Kidney Antibodies  >1 publications with LXN and Kidney
 Ovary Antibodies  >1 publications with LXN and Ovary
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