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LEPR recombinant protein :: Leptin receptor (LEPR) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1256655
SDS-PAGE
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Leptin receptor (LEPR), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Pig Leptin receptor (LEPR), partial

 Product Gene Name   

LEPR recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for O02671
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Sus scrofa (Pig)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of LEPR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 SDS-PAGE of LEPR recombinant protein    LEPR recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for LEPR. It may not necessarily be applicable to this product.
 NCBI GI #    66793463
 NCBI GeneID    396836
 NCBI Accession #    NP_001019758.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001024587.1 [Other Products]
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 UniProt Primary Accession #    O02671 [Other Products]
 UniProt Secondary Accession #    Q95257; Q9MZS2; Q9N1F9; Q9XSN9 [Other Products]
 UniProt Related Accession #    O02671 [Other Products]
 Molecular Weight    132,523 Da
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 NCBI Official Full Name    leptin receptor
 NCBI Official Symbol    LEPR [Similar Products]
 NCBI Protein Information    leptin receptor
 UniProt Protein Name    Leptin receptor
 UniProt Synonym Protein Names   
OB receptor; OB-R; CD_antigen: CD295
 Protein Family    Leptin receptor
 UniProt Gene Name    LEPR [Similar Products]
 UniProt Synonym Gene Names    OBR; LEP-R; OB-R [Similar Products]
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 UniProt Comments for LEPR    Receptor for hormone LEP/leptin (). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production ().
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 Research Articles on LEPR    1. study has allowed a transcriptional characterization of LEP and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LEPR recombinant proteinPathways associated with LEPR recombinant protein
 Reference Product  PubMed Publications
 LEP recombinant protein  >193 publications with LEPR and LEP
 STAT3 recombinant protein  >62 publications with LEPR and STAT3
 JAK2 recombinant protein  >17 publications with LEPR and JAK2
 SOCS3 recombinant protein  >11 publications with LEPR and SOCS3
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with LEPR recombinant proteinOrgans/Tissues associated with LEPR recombinant protein
 Disease Name  Pubmed Publications
 Obesity Antibodies  >432 publications with LEPR and Obesity
 Peripheral Nervous System Diseases Antibodies  >412 publications with LEPR and Peripheral Nervous System Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >359 publications with LEPR and Drug-Related Side Effects and Adverse Reactions
 Overweight Antibodies  >286 publications with LEPR and Overweight
 Disease Models, Animal Antibodies  >266 publications with LEPR and Disease Models, Animal
 Diabetes Mellitus Antibodies  >239 publications with LEPR and Diabetes Mellitus
 Inflammation Antibodies  >224 publications with LEPR and Inflammation
 Diabetes Mellitus, Type 2 Antibodies  >138 publications with LEPR and Diabetes Mellitus, Type 2
 Insulin Resistance Antibodies  >126 publications with LEPR and Insulin Resistance
 Necrosis Antibodies  >117 publications with LEPR and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >255 publications with LEPR and Liver
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