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LCMT1 recombinant protein :: Leucine Carboxyl Methyltransferase 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS145387 LCMT1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Leucine Carboxyl Methyltransferase 1 (LCMT1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Leucine Carboxyl Methyltransferase 1

 Product Synonym Names    LCMT1 Human; Leucine Carboxyl Methyltransferase 1 Human Recombinant; Leucine carboxyl methyltransferase 1; Protein-leucine O-methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1; LCMT1; LCMT; PPMT1; CGI-68
 Product Gene Name   

LCMT1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MGSHMA TRQR ESSITSCCST SSCDADDEGV RGTCEDASLC KRFAVSIGYW HDPYIQHFVR LSKERKAPEI NRGYFARVHG VSQLIKAFLR KTECHCQIVN LGAGMDTTFW RLKDEDLLPS KYFEVDFPMI VTRKLHSIKC KPPLSSPILE LHSEDTLQMD GHILDSKRYA VIGADLRDLS ELEEKLKKCN MNTQLPTLLI AECVLVYMTP EQSANLLKWA ANSFERAMFI NYEQVNMGDR FGQIMIENLR RRQCDLAGVE TCKSLESQKE RLLSNGWETA SAVDMMELYN RLPRAEVSRI ESLEFLDEME LLEQLMRHYC LCWATKGGNE LGLKEITY.< /u>
 OMIM    610286
 3D Structure    ModBase 3D Structure for Q9UIC8
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The LCMT1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 1mM DTT and 0.15M NaCl.
Sterile Filtered colorless solution.
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 Other Notes    Small volumes of LCMT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LCMT1 recombinant protein

   Description: LCMT1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 358 amino acids (1-334) and having a molecular mass of 41kDa.LCMT1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: LCMT1 is a member of the LCMT family, methyltransferase superfamily. LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A to form alpha-leucine ester residues.
 Product Categories/Family for LCMT1 recombinant protein    ENZYMES; Enzymes; Transferase
NCBI/Uniprot data below describe general gene information for LCMT1. It may not necessarily be applicable to this product.
 NCBI GI #    74048545
 NCBI GeneID    51451
 NCBI Accession #    NP_001027563.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001032391.1 [Other Products]
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 UniProt Primary Accession #    Q9UIC8 [Other Products]
 UniProt Secondary Accession #    Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9Y378; A6NL89; A8K770 [Other Products]
 UniProt Related Accession #    Q9UIC8 [Other Products]
 Molecular Weight    32,172 Da
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 NCBI Official Full Name    leucine carboxyl methyltransferase 1 isoform b
 NCBI Official Synonym Full Names    leucine carboxyl methyltransferase 1
 NCBI Official Symbol    LCMT1 [Similar Products]
 NCBI Official Synonym Symbols   
LCMT; PPMT1; CGI-68
[Similar Products]
 NCBI Protein Information    leucine carboxyl methyltransferase 1; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1; protein phosphatase methyltransferase 1; protein-leucine O-methyltransferase
 UniProt Protein Name    Leucine carboxyl methyltransferase 1
 UniProt Synonym Protein Names   
Protein-leucine O-methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
 Protein Family    Leucine carboxyl methyltransferase
 UniProt Gene Name    LCMT1 [Similar Products]
 UniProt Synonym Gene Names    LCMT [Similar Products]
 UniProt Entry Name    LCMT1_HUMAN
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 NCBI Summary for LCMT1    LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for LCMT1    LCMT1: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - histidine; EC 2.1.1.233; Lipid Metabolism - androgen and estrogen; Methyltransferase; Other Amino Acids Metabolism - selenoamino acid

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: cytosol

Molecular Function: protein binding; C-terminal protein carboxyl methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity

Biological Process: regulation of apoptosis; protein amino acid methylation; C-terminal protein amino acid methylation; protein modification process; negative regulation of protein complex assembly
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 Research Articles on LCMT1    1. alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LCMT1 recombinant proteinOrgans/Tissues associated with LCMT1 recombinant protein
 Reference Product  PubMed Publications
 PPP2CA recombinant protein  >9 publications with LCMT1 and PPP2CA
 PPP2CB recombinant protein  >8 publications with LCMT1 and PPP2CB
 PPP2R4 recombinant protein  >1 publications with LCMT1 and PPP2R4
 PPP2R2A recombinant protein  >1 publications with LCMT1 and PPP2R2A
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with LCMT1 and Brain
 Vascular Antibodies  >1 publications with LCMT1 and Vascular
 Embryonic Tissue Antibodies  >1 publications with LCMT1 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with LCMT1 and Pancreas
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