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LRRK2 recombinant protein :: Leucine Rich Repeat Kinase 2 (LRRK2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2012043 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
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Unit / Price
0.01 mg  /  $150 +1 FREE 8GB USB
0.05 mg  /  $290 +1 FREE 8GB USB
0.1 mg  /  $455 +1 FREE 8GB USB
0.2 mg  /  $560 +1 FREE 8GB USB
0.5 mg  /  $1,080 +1 FREE 8GB USB
1 mg  /  $1,610 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Leucine Rich Repeat Kinase 2 (LRRK2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Leucine Rich Repeat Kinase 2 (LRRK2)

 Product Gene Name   

LRRK2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF-FP AIRDYHFVNA TEESDALAKL RKTIINESLN FKIRDQLVVG QLIPDCYVEL EKIILSERKN VPIEFPVIDR KRLLQLVREN QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP KWLCKIMAQI LTVKVEGCPK HPKGIISRRD VEKFLSKKRK FPKNYMSQYF KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI ELPHCENSEI IIRLYEMPYF PMGFWSRLIN RLLEISPYML SGRERALRP
 Chromosome Location    Chromosome: 12; NC_000012.11 (40618813..40763087). Location: 12q12
 OMIM    168600
 3D Structure    ModBase 3D Structure for Q5S007
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and preservative.
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 Organism    Homo sapiens (Human)
 Subcellular Location    Cytoplasm. Membrane;Peripheral membrane protein. Mitochondrion.Residues
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile ddH2O.
 Predicted Isoelectric Point    7.8
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of LRRK2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for LRRK2 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-Page of LRRK2 recombinant protein    LRRK2 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for LRRK2. It may not necessarily be applicable to this product.
 NCBI GI #    171846278
 NCBI GeneID    120892
 NCBI Accession #    NP_940980.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_198578.3 [Other Products]
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 UniProt Primary Accession #    Q5S007 [Other Products]
 UniProt Secondary Accession #    Q6ZS50; Q8NCX9; A6NJU2 [Other Products]
 UniProt Related Accession #    Q5S007 [Other Products]
 Molecular Weight    31.0kDa
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 NCBI Official Full Name    leucine-rich repeat serine/threonine-protein kinase 2
 NCBI Official Synonym Full Names    leucine-rich repeat kinase 2
 NCBI Official Symbol    LRRK2 [Similar Products]
 NCBI Official Synonym Symbols   
PARK8; RIPK7; ROCO2; AURA17; DARDARIN
[Similar Products]
 NCBI Protein Information    leucine-rich repeat serine/threonine-protein kinase 2; augmented in rheumatoid arthritis 17
 UniProt Protein Name    Leucine-rich repeat serine/threonine-protein kinase 2
 UniProt Synonym Protein Names   
Dardarin
 Protein Family    Leucine-rich repeat serine/threonine-protein kinase
 UniProt Gene Name    LRRK2 [Similar Products]
 UniProt Synonym Gene Names    PARK8 [Similar Products]
 UniProt Entry Name    LRRK2_HUMAN
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 NCBI Summary for LRRK2    This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LRRK2    LRRK2: a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). May play a role in the etiology of Parkinson disease. May also have GTPase activity. Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Interacts with PARK2, PRDX3 and TPCN2. Expressed throughout the adult brain, but at a lower level than in heart and liver. Expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas. Defects in LRRK2 are the cause of Parkinson disease type 8 (PARK8). A slowly progressive neurodegenerative disorder characterized by bradykinesia, rigidity, resting tremor, postural instability, neuronal loss in the substantia nigra, and the presence of neurofibrillary MAPT (tau)-positive and Lewy bodies in some patients.

Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; TKL group; LRRK family

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: dendrite cytoplasm; Golgi apparatus; extracellular space; mitochondrion; lysosome; dendrite; terminal button; inclusion body; trans-Golgi network; cytosol; lipid raft; mitochondrial outer membrane; cell soma; mitochondrial matrix; mitochondrial inner membrane; cytoplasm; cytoplasmic vesicle; endosome; neuron projection; synaptic vesicle membrane; endoplasmic reticulum; perikaryon; axon; mitochondrial membrane; plasma membrane; cell junction

Molecular Function: tubulin binding; GTPase activity; identical protein binding; GTP-dependent protein kinase activity; clathrin binding; protein homodimerization activity; Rho GTPase binding; GTP binding; actin binding; GTPase activator activity; protein kinase activity; MAP kinase kinase activity; protein serine/threonine kinase activity; SNARE binding; protein binding; protein kinase A binding; syntaxin-1 binding; kinase activity; glycoprotein binding; ATP binding

Biological Process: regulation of synaptic transmission, glutamatergic; positive regulation of protein binding; activation of MAPKK activity; activation of MAPK activity; protein amino acid autophosphorylation; regulation of neuron maturation; determination of adult life span; protein amino acid phosphorylation; positive regulation of MAP kinase activity; tangential migration from the subventricular zone to the olfactory bulb; negative regulation of protein amino acid phosphorylation; regulation of dopamine receptor signaling pathway; small GTPase mediated signal transduction; regulation of mitochondrial depolarization; negative regulation of protein binding; neuromuscular junction development; positive regulation of autophagy; positive regulation of dopamine receptor signaling pathway; olfactory bulb development; MAPKKK cascade; peptidyl-threonine phosphorylation; endocytosis; regulation of locomotion; peptidyl-serine phosphorylation; positive regulation of programmed cell death; regulation of membrane potential; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; intracellular distribution of mitochondria; autophagy; positive regulation of protein amino acid phosphorylation; response to oxidative stress; regulation of excitatory postsynaptic membrane potential; neurite morphogenesis; positive regulation of GTPase activity

Disease: Parkinson Disease 8, Autosomal Dominant
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 Research Articles on LRRK2    1. The findings of this study suggested that 22q11.2 deletions represent a novel genetic risk factor for early-onset PD with variable neuropathological presentation reminiscent of LRRK2-associated PD neuropathology
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LRRK2 recombinant proteinPathways associated with LRRK2 recombinant protein
 Reference Product  PubMed Publications
 PARK2 recombinant protein  >805 publications with LRRK2 and PARK2
 SNCA recombinant protein  >123 publications with LRRK2 and SNCA
 MKKS recombinant protein  >3 publications with LRRK2 and MKKS
 STUB1 recombinant protein  >2 publications with LRRK2 and STUB1
 EIF2C2 recombinant protein  >1 publications with LRRK2 and EIF2C2
 CDC37 recombinant protein  >1 publications with LRRK2 and CDC37
 DVL1 recombinant protein  >1 publications with LRRK2 and DVL1
 MSN recombinant protein  >1 publications with LRRK2 and MSN
 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Wnt Signaling Pathway And Pluripotency antibodies  Wnt Signaling Pathway And Pluripotency Diagram
Diseases associated with LRRK2 recombinant proteinOrgans/Tissues associated with LRRK2 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >839 publications with LRRK2 and Nervous System Diseases
 Parkinson Disease Antibodies  >835 publications with LRRK2 and Parkinson Disease
 Neurodegenerative Diseases Antibodies  >819 publications with LRRK2 and Neurodegenerative Diseases
 Movement Disorders Antibodies  >813 publications with LRRK2 and Movement Disorders
 Parkinsonian Disorders Antibodies  >797 publications with LRRK2 and Parkinsonian Disorders
 Death Antibodies  >94 publications with LRRK2 and Death
 Disease Models, Animal Antibodies  >80 publications with LRRK2 and Disease Models, Animal
 Nerve Degeneration Antibodies  >39 publications with LRRK2 and Nerve Degeneration
 Inflammation Antibodies  >19 publications with LRRK2 and Inflammation
 PARKINSON DISEASE 8, AUTOSOMAL DOMINANT Antibodies  >18 publications with LRRK2 and PARKINSON DISEASE 8, AUTOSOMAL DOMINANT
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >288 publications with LRRK2 and Brain
 Nerve Antibodies  >73 publications with LRRK2 and Nerve
 Blood Antibodies  >41 publications with LRRK2 and Blood
 Kidney Antibodies  >18 publications with LRRK2 and Kidney
 Skin Antibodies  >8 publications with LRRK2 and Skin
 Eye Antibodies  >8 publications with LRRK2 and Eye
 Embryonic Tissue Antibodies  >7 publications with LRRK2 and Embryonic Tissue
 Lung Antibodies  >6 publications with LRRK2 and Lung
 Bone Antibodies  >5 publications with LRRK2 and Bone
 Bone Marrow Antibodies  >4 publications with LRRK2 and Bone Marrow
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