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Spn recombinant protein :: Leukosialin (Spn) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS955599 Spn recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Leukosialin (Spn), Recombinant Protein

 Also Known As   

Recombinant Mouse Leukosialin (Spn)

 Product Synonym Names    Leukosialin; B-cell differentiation antigen LP-3; Leukocyte sialoglycoprotein; Lymphocyte antigen 48; Ly-48; Sialophorin; CD_antigen=; CD43
 Product Gene Name   

Spn recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    20-248
 Sequence    D SLQRTTMLPS TPHITAPSTS EAQNASPSVS VGSGTVDSKE TISPWGQTTI PVSLTPLETT ELSSLETSAG ASMSTPVPEP TASQEVSSKT SALLPEPSNV ASDPPVTAAN PVTDGPAANP VTDGTAASTS ISKGTSAPPT TVTTSSNETS GPSVATTVSS KTSGPPVTTA TGSLGPSSEM HGLPATTATS SVESSSVARG TSVSSRKTST TSTQDPITTR SPSQESSG
 3D Structure    ModBase 3D Structure for P15702
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Spn recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Spn. It may not necessarily be applicable to this product.
 NCBI GI #    83716013
 NCBI GeneID    20737
 NCBI Accession #    NP_001032899.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001037810.2 [Other Products]
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 UniProt Primary Accession #    P15702 [Other Products]
 UniProt Related Accession #    P15702 [Other Products]
 Molecular Weight    40,038 Da
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 NCBI Official Full Name    leukosialin
 NCBI Official Synonym Full Names    sialophorin
 NCBI Official Symbol    Spn [Similar Products]
 NCBI Official Synonym Symbols   
Cd43; Ly48; Galgp; Ly-48; A630014B01Rik
[Similar Products]
 NCBI Protein Information    leukosialin; 3E8 antigen; lymphocyte antigen 48; leukocyte sialoglycoprotein; B-cell differentiation antigen LP-3
 UniProt Protein Name    Leukosialin
 UniProt Synonym Protein Names   
B-cell differentiation antigen LP-3; Leukocyte sialoglycoprotein; Lymphocyte antigen 48; Ly-48; Sialophorin; CD_antigen: CD43
 Protein Family    Leukosialin
 UniProt Gene Name    Spn [Similar Products]
 UniProt Synonym Gene Names    Ly-48 [Similar Products]
 UniProt Entry Name    LEUK_MOUSE
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 UniProt Comments for Spn    sialophorin: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX. Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: extracellular space; microvillus; cell surface; membrane; integral to plasma membrane; integral to membrane; basement membrane; uropod; external side of plasma membrane; cleavage furrow

Molecular Function: protein domain specific binding; protein binding

Biological Process: positive regulation of tumor necrosis factor biosynthetic process; regulation of immune response; regulation of defense response to virus; negative regulation of cell adhesion; negative thymic T cell selection; negative regulation of T cell proliferation; response to protozoan; cell surface receptor linked signal transduction; T cell costimulation; defense response to bacterium; positive regulation of T cell proliferation; positive regulation of protein amino acid phosphorylation; negative regulation of type IV hypersensitivity; negative regulation of T cell activation
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 Research Articles on Spn    1. We have identified a robust physiologic role for CD43 in a relevant animal model and established an important in vivo function for CD43-dependent regulation of IFN-gamma production.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Spn recombinant proteinPathways associated with Spn recombinant protein
 Reference Product  PubMed Publications
 Icam1 recombinant protein  >10 publications with Spn and Icam1
 Lgals1 recombinant protein  >3 publications with Spn and Lgals1
 Siglec1 recombinant protein  >1 publications with Spn and Siglec1
 Products by Pathway  Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram
Diseases associated with Spn recombinant proteinOrgans/Tissues associated with Spn recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >84 publications with Spn and Nervous System Diseases
 Inflammation Antibodies  >41 publications with Spn and Inflammation
 Pain Antibodies  >35 publications with Spn and Pain
 Cardiovascular Diseases Antibodies  >27 publications with Spn and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >25 publications with Spn and Disease Models, Animal
 Necrosis Antibodies  >25 publications with Spn and Necrosis
 Hypertension Antibodies  >19 publications with Spn and Hypertension
 Liver Neoplasms Antibodies  >14 publications with Spn and Liver Neoplasms
 Liver Diseases Antibodies  >14 publications with Spn and Liver Diseases
 Breast Neoplasms Antibodies  >8 publications with Spn and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >278 publications with Spn and Blood
 Bone Antibodies  >80 publications with Spn and Bone
 Bone Marrow Antibodies  >51 publications with Spn and Bone Marrow
 Spleen Antibodies  >48 publications with Spn and Spleen
 Liver Antibodies  >44 publications with Spn and Liver
 Thymus Antibodies  >25 publications with Spn and Thymus
 Inner Ear Antibodies  >5 publications with Spn and Inner Ear
 Embryonic Tissue Antibodies  >5 publications with Spn and Embryonic Tissue
 Adipose Tissue Antibodies  >1 publications with Spn and Adipose Tissue
 Uncharacterized Tissue Antibodies  >1 publications with Spn and Uncharacterized Tissue
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