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LPL recombinant protein :: Lipoprotein Lipase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS145361 LPL recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,775 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lipoprotein Lipase (LPL), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Lipoprotein Lipase, HEK

 Product Synonym Names    LPL Human, HEK; Lipoprotein Lipase Human Recombinant, HEK; Lipoprotein lipase; LPL; LIPD; HDLCQ11; LPL, HEK
 Product Gene Name   

LPL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    HVDYKDD DDK PAGADQ RRDF IDIESKFALR TPEDTAEDTC HLIPGVAESV ATCHFNHSSK TFMVIHGWTV TGMYESWVPK ADQRRDF IDIESKFALR TPEDTAEDTC HLIPGVAESV ATCHFNHSSK TFMVIHGWTV TGMYESWVPK LVAALY KREP DSNVIVVDWL SRAQEHYPVS AGYTKLVGQD VARFINWMEE EFNYPLDNVH LLGYSLGAHA AGIAGSLTNK KVNRIT GLDP AGPNFEYAEA PSRLSPDDAD FVDVLHTFTR GSPGRSIGIQ KPVGHVDIYP NGGTFQPGCN IGEAIRVIAE RGLGDV DQLV KCSHERSIHL FIDSLLNEEN PSKAYRCSSK EAFEKGLCLS CRKNRCNNLG YEISKVRAKR SSKMYLKTRS QMPYKV FHYQ VKIHFSGTES ETHTNQAFEI SLYGTVAESE NIPFTLPEVS TNKTYSFLIY TEVDIGELLM LKLKWKSDSY FSWSDW WSSP GFAIQKIRVK AGETQKKVIF CSREKVSHLQ KGKAPAVFVK CHDKSLNKKS G.
 OMIM    238600
 3D Structure    ModBase 3D Structure for P06858
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 Host    HEK293 cells
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 Form/Format    LPL was filtered (0.4 um) and lyophilized from 0.5 mg/ml in 20mM Tris buffer and 50mM NaCl, pH 7.5.
Filtered white lyophilized powder.
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 Solubility    It is recomended to add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
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 Preparation and Storage    Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of LPL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LPL recombinant protein

   Description: The Recombinant Human LPL produced in HEK293 cell line has a molecular mass of 51.8kDa containing 461 amino acid residues of the human LPL (Ala28-Gly475, variant Asn > Ser318) and fused to a 13 a.a. Flag-tag at N-terminus.

Introduction: LPL is a lipoprotein lipase, which is expressed in the heart, muscle, and adipose tissue. LPL acts as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Type I hyperlipoproteinemia is a result of severe mutations which cause LPL deficiency, whereas less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. Lipoprotein lipase (LPL) is a fundamental enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. LPL also promotes the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF) secretion and induction of vascular smooth muscle cell proliferation.
 Product Categories/Family for LPL recombinant protein    ENZYMES; Enzymes; Lipase
NCBI/Uniprot data below describe general gene information for LPL. It may not necessarily be applicable to this product.
 NCBI GI #    4557727
 NCBI GeneID    4023
 NCBI Accession #    NP_000228.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000237.2 [Other Products]
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 UniProt Primary Accession #    P06858 [Other Products]
 UniProt Secondary Accession #    Q16282; Q16283; Q96FC4; B2R5T9 [Other Products]
 UniProt Related Accession #    P06858 [Other Products]
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 NCBI Official Full Name    lipoprotein lipase
 NCBI Official Synonym Full Names    lipoprotein lipase
 NCBI Official Symbol    LPL [Similar Products]
 NCBI Official Synonym Symbols   
LIPD; HDLCQ11
[Similar Products]
 NCBI Protein Information    lipoprotein lipase
 UniProt Protein Name    Lipoprotein lipase
 Protein Family    Lipoprotein
 UniProt Gene Name    LPL [Similar Products]
 UniProt Synonym Gene Names    LIPD; LPL [Similar Products]
 UniProt Entry Name    LIPL_HUMAN
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 NCBI Summary for LPL    LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LPL    LPL: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency); also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis. Belongs to the AB hydrolase superfamily. Lipase family.

Protein type: Membrane protein, GPI anchor; Phospholipase; EC 3.1.1.34; Lipid Metabolism - glycerolipid

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface; plasma membrane; extracellular region

Molecular Function: heparin binding; triacylglycerol lipase activity; protein binding; lipoprotein lipase activity; apolipoprotein binding; phospholipase activity; triglyceride binding; receptor binding

Biological Process: response to drug; phototransduction, visible light; triacylglycerol metabolic process; phospholipid metabolic process; triacylglycerol catabolic process; triacylglycerol biosynthetic process; lipoprotein metabolic process; response to cold; retinoid metabolic process; fatty acid biosynthetic process

Disease: Hyperlipoproteinemia, Type I; Hyperlipidemia, Familial Combined
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 Research Articles on LPL    1. The HindIII G allele in lipoprotein lipase gene may be a protective factor against the development of hypertensive intracranial hemorrhage among the Han Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LPL recombinant proteinPathways associated with LPL recombinant protein
 Reference Product  PubMed Publications
 APOE recombinant protein  >323 publications with LPL and APOE
 APOB recombinant protein  >238 publications with LPL and APOB
 APOC2 recombinant protein  >187 publications with LPL and APOC2
 FABP4 recombinant protein  >69 publications with LPL and FABP4
 APOC3 recombinant protein  >51 publications with LPL and APOC3
 APOA1 recombinant protein  >38 publications with LPL and APOA1
 LRP1 recombinant protein  >9 publications with LPL and LRP1
 INS recombinant protein  >8 publications with LPL and INS
 LIPE recombinant protein  >8 publications with LPL and LIPE
 APOA2 recombinant protein  >4 publications with LPL and APOA2
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
Diseases associated with LPL recombinant proteinOrgans/Tissues associated with LPL recombinant protein
 Disease Name  Pubmed Publications
 Dyslipidemias Antibodies  >766 publications with LPL and Dyslipidemias
 Hyperlipidemias Antibodies  >719 publications with LPL and Hyperlipidemias
 Cardiovascular Diseases Antibodies  >662 publications with LPL and Cardiovascular Diseases
 Hypertriglyceridemia Antibodies  >558 publications with LPL and Hypertriglyceridemia
 Atherosclerosis Antibodies  >502 publications with LPL and Atherosclerosis
 Obesity Antibodies  >488 publications with LPL and Obesity
 Fatty Liver Antibodies  >313 publications with LPL and Fatty Liver
 Heart Diseases Antibodies  >293 publications with LPL and Heart Diseases
 Insulin Resistance Antibodies  >289 publications with LPL and Insulin Resistance
 Necrosis Antibodies  >173 publications with LPL and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2429 publications with LPL and Blood
 Adipose Tissue Antibodies  >1268 publications with LPL and Adipose Tissue
 Connective Tissue Antibodies  >956 publications with LPL and Connective Tissue
 Liver Antibodies  >903 publications with LPL and Liver
 Muscle Antibodies  >833 publications with LPL and Muscle
 Heart Antibodies  >648 publications with LPL and Heart
 Vascular Antibodies  >417 publications with LPL and Vascular
 Intestine Antibodies  >225 publications with LPL and Intestine
 Bone Antibodies  >180 publications with LPL and Bone
 Kidney Antibodies  >162 publications with LPL and Kidney
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