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LUM recombinant protein :: Lumican Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS145957 LUM recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lumican, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Lumican

 Product Synonym Names    LUM Human; Lumican Human Recombinant; Lumican; LDC; Lumican Proteoglycan; Keratan Sulfate Proteoglycan Lumican; SLRR2D; KSPG Lumican
 Product Gene Name   

LUM recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MGSQYY DYDF PLSIYGQSSP NCAPECNCPE SYPSAMYCDE LKLKSVPMVP PGIKYLYLRN NQIDHIDEKA FENVTDLQWL ILDHNLLENS KIKGRVFSKL KQLKKLHINH NNLTESVGPL PKSLEDLQLT HNKITKLGSF EGLVNLTFIH LQHNRLKEDA VSAAFKGLKS LEYLDLSFNQ IARLPSGLPV SLLTLYLDNN KISNIPDEYF KRFNALQYLR LSHNELADSG IPGNSFNVSS LVELDLSYNK LKNIPTVNEN LENYYLEVNQ LEKFDIKSFC KILGPLSYSK IKHLRLDGNR ISETSLPPDM YECLRVANEV TLN
 OMIM    600616
 3D Structure    ModBase 3D Structure for P51884
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    LUM protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
 Other Notes    Small volumes of LUM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LUM recombinant protein

   Description: LUM Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 343 amino acids (19-338a.a) and having a molecular mass of 30.9kDa.LUM is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Lumican also known as LUM belongs to the small leucine-rich proteoglycan (SLRP) family which comprises decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. Furthermore we can see that in these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the main keratan sulfate proteoglycan of the cornea however LUM is also distributed in interstitial collagenous matrices throughout the body. Lumican regulates collagen fibril organization and circumferential growth, corneal transparency, epithelial cell migration and tissue repair. Among the diseases associated with LUM is posterior amorphous corneal dystrophy.
 Product Categories/Family for LUM recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for LUM. It may not necessarily be applicable to this product.
 NCBI GI #    4505047
 NCBI GeneID    4060
 NCBI Accession #    NP_002336.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002345.3 [Other Products]
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 UniProt Primary Accession #    P51884 [Other Products]
 UniProt Secondary Accession #    Q96QM7; B2R6R5 [Other Products]
 UniProt Related Accession #    P51884 [Other Products]
 Molecular Weight    38,429 Da
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 NCBI Official Full Name    lumican
 NCBI Official Synonym Full Names    lumican
 NCBI Official Symbol    LUM [Similar Products]
 NCBI Official Synonym Symbols   
LDC; SLRR2D
[Similar Products]
 NCBI Protein Information    lumican; KSPG lumican; keratan sulfate proteoglycan lumican; lumican proteoglycan
 UniProt Protein Name    Lumican
 UniProt Synonym Protein Names   
Keratan sulfate proteoglycan lumican; KSPG lumican
 Protein Family    Lumican
 UniProt Gene Name    LUM [Similar Products]
 UniProt Synonym Gene Names    LDC; SLRR2D; KSPG lumican [Similar Products]
 UniProt Entry Name    LUM_HUMAN
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 NCBI Summary for LUM    This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LUM    LUM: a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q21.33

Cellular Component: extracellular matrix; extracellular space; lysosomal lumen; proteinaceous extracellular matrix; fibrillar collagen; Golgi lumen; extracellular region

Molecular Function: collagen binding; protein binding; extracellular matrix structural constituent

Biological Process: keratan sulfate metabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; glycosaminoglycan metabolic process; visual perception; cartilage development; keratan sulfate biosynthetic process; carbohydrate metabolic process; positive regulation of transcription from RNA polymerase II promoter; pathogenesis; keratan sulfate catabolic process; response to organic cyclic substance
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 Research Articles on LUM    1. Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LUM recombinant proteinPathways associated with LUM recombinant protein
 Reference Product  PubMed Publications
 DCN recombinant protein  >18 publications with LUM and DCN
 KERA recombinant protein  >12 publications with LUM and KERA
 FMOD recombinant protein  >10 publications with LUM and FMOD
 COL1A2 recombinant protein  >7 publications with LUM and COL1A2
 ACAN recombinant protein  >3 publications with LUM and ACAN
 OGN recombinant protein  >2 publications with LUM and OGN
 Products by Pathway  Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
 Defective EXT2 Causes Exostoses 2 Pathway antibodies  Defective EXT2 Causes Exostoses 2 Pathway Diagram
 Defective PAPSS2 Causes SEMD-PA Pathway antibodies  Defective PAPSS2 Causes SEMD-PA Pathway Diagram
Diseases associated with LUM recombinant proteinOrgans/Tissues associated with LUM recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >241 publications with LUM and Nervous System Diseases
 Brain Diseases Antibodies  >146 publications with LUM and Brain Diseases
 Carcinoma Antibodies  >103 publications with LUM and Carcinoma
 Inflammation Antibodies  >74 publications with LUM and Inflammation
 Disease Models, Animal Antibodies  >71 publications with LUM and Disease Models, Animal
 Breast Neoplasms Antibodies  >66 publications with LUM and Breast Neoplasms
 Kidney Diseases Antibodies  >61 publications with LUM and Kidney Diseases
 Necrosis Antibodies  >54 publications with LUM and Necrosis
 Liver Diseases Antibodies  >52 publications with LUM and Liver Diseases
 Neoplasms, Experimental Antibodies  >45 publications with LUM and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >539 publications with LUM and Blood
 Bone Antibodies  >163 publications with LUM and Bone
 Vascular Antibodies  >161 publications with LUM and Vascular
 Lung Antibodies  >154 publications with LUM and Lung
 Brain Antibodies  >123 publications with LUM and Brain
 Bone Marrow Antibodies  >104 publications with LUM and Bone Marrow
 Kidney Antibodies  >93 publications with LUM and Kidney
 Liver Antibodies  >92 publications with LUM and Liver
 Heart Antibodies  >82 publications with LUM and Heart
 Muscle Antibodies  >80 publications with LUM and Muscle
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