NP_037110.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39.2 kDa
NCBI Official Full Name
lutropin-choriogonadotropic hormone receptor
NCBI Official Synonym Full Names
luteinizing hormone/choriogonadotropin receptor
NCBI Protein Information
lutropin-choriogonadotropic hormone receptor
UniProt Protein Name
Lutropin-choriogonadotropic hormone receptor
UniProt Synonym Protein Names
Luteinizing hormone receptor; LSH-R
UniProt Synonym Gene Names
UniProt Entry Name
LSHR_RAT
NCBI Summary for Lhcgr
for both luteinizing hormone and choriogonadotropin; involved in reproductive development and function [RGD, Feb 2006]
UniProt Comments for Lhcgr
LHR: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in LHCGR are a cause of familial male precocious puberty (FMPP); also known as testotoxicosis. In FMPP the receptor is constitutively activated. Defects in LHCGR are the cause of luteinizing hormone resistance (LHR); also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1
Cellular Component: cytoplasm; endoplasmic reticulum; endosome; extracellular space; integral to plasma membrane; lysosome; nucleus; plasma membrane; receptor complex
Molecular Function: ATPase binding; identical protein binding; lutropin-choriogonadotropic hormone receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein homodimerization activity
Biological Process: adenylate cyclase activation; arachidonic acid secretion; central nervous system development; cognition; development of secondary male sexual characteristics; female gonad development; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); hormone-mediated signaling; luteinizing hormone signaling pathway; male gonad development; ovarian follicle development; ovulation cycle process; positive regulation of calcium-mediated signaling; positive regulation of hormone biosynthetic process; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of release of sequestered calcium ion into cytosol; protein targeting to lysosome; regulation of steroid biosynthetic process; response to drug; spermatogenesis; uterus development
Product References and Citations for Lhcgr recombinant protein
Lutropin-choriogonadotropin receptor
an unusual member of the G protein-coupled receptor family.McFarland K.C., Sprengel R., Phillips H.S., Koehler M., Rosemblit N., Nikolics K., Segaloff D.L., Seeburg P.H.Science 245:494-499(1989)
Expression of the LH/CG receptor gene in rat ovarian tissue is regulated by an extensive alternative splicing of the primary transcript.Aatsinki J.T., Pietila E.M., Lakkakorpi J.T., Rajaniemi H.J.Mol. Cell. Endocrinol. 84:127-135(1992)
Structure of the luteinizing hormone receptor gene and multiple exons of the coding sequence.Koo Y.B., Slaughter R.G., Ji T.H.Endocrinology 128:2297-2308(1991)
Cloning of rat lutropin (LH)
receptor analogs lacking the soybean lectin domain.Bernard M.P., Myers R.V., Moyle W.R.Mol. Cell. Endocrinol. 71:R19-R23(1990)
Structure of the lutropin/choriogonadotropin receptor.Segaloff D.L., Sprengel R., Nikolics K., Ascoli M.Recent Prog. Horm. Res. 46:261-301(1990)
Structural organization of the rat luteinizing hormone (LH)
receptor gene.Tsai-Morris C.H., Buczko E., Wang W., Xie X.-Z., Dufau M.L.J. Biol. Chem. 266:11355-11359(1991)
Intronic nature of the rat luteinizing hormone receptor gene defines a soluble receptor subspecies with hormone binding activity.Tsai-Morris C.H., Buczko E., Wang W., Dufau M.L.J. Biol. Chem. 265:19385-19388(1990)
Characterization and structure of ovarian and testicular LH/hCG receptors.Dufau M.L., Minegishi T., Buczko E.S., Delgado C.J., Zhang R.J. Steroid Biochem. 33:715-720(1989)
Purification, characterization, and amino-terminal sequence of rat ovarian receptor for luteinizing hormone/human choriogonadotropin.Roche P.C., Ryan R.J.J. Biol. Chem. 264:4636-4641(1989)
Asp383 in the second transmembrane domain of the lutropin receptor is important for high affinity hormone binding and cAMP production.Ji I., Ji T.H.J. Biol. Chem. 266:14953-14957(1991)
The lutropin/choriogonadotropin receptor is palmitoylated at intracellular cysteine residues.Zhu H., Wang H., Ascoli M.Mol. Endocrinol. 9:141-150(1995)
Research Articles on Lhcgr
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Products associated with Lhcgr recombinant protein
Pathways associated with Lhcgr recombinant protein
Diseases associated with Lhcgr recombinant protein
Organs/Tissues associated with Lhcgr recombinant protein
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