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LYVE-1 recombinant protein :: Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143392 LYVE-1 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,125 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 (LYVE-1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 (25-235)

 Product Synonym Names    LYVE1 Human 25-235 a.a.; Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 (25-235 a.a) Human Recombinant; HAR; XLKD1; LYVE-1; CRSBP-1; LYVE1; Lymphatic vessel endothelial hyaluronic acid receptor 1 precursor; Cell surface retention sequence-binding protein 1; Hyaluronic acid receptor; Extracellular link domain-containing protein; LYVE-1 (25-235)
 Product Gene Name   

LYVE-1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    DPLRAEELS IQVSCRIMGI TLVSKKANQQ LNFTEAKEAC RLLGLSLAGK DQVETALKAS FETCSYGWVG DGFVVISRIS PNPKCGKNGV GVLIRKVPVS RQFAAYCYNS SDTWTNSCIP EIITTKDPIF NTQTATQTTE FIVSDSTYSV ASPYSTIPAP TTTPPAPAST SIPRRKKLIC VTEVFMETST MSTETEPFVE NKAAFKNEAA GFGGSGRLVP RGSHHHHHH
 OMIM    605702
 3D Structure    ModBase 3D Structure for Q9Y5Y7
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 Host    High Five insect cells
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 Purity/Purification    Greater than 90.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The LYVE1 protein solution contains 20mM Tris buffer pH-7.5 and 10% Glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    LYVE1 although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of LYVE-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LYVE-1 recombinant protein

   Description: LYVE1 Human Recombinant produced in insect cells is a single, glycosylated polypeptide chain containing 229 amino acids and having a molecular mass of 24.8 kDa. As a result of glycosylation, the LYVE1 migrates on SDS-PAGE at approximately 50 kDa.

Introduction: LYVE1 is a selective marker of the lymphatic endothelium & a surface endocytic receptor for both soluble and immobilized hyaluronan, LYVE1 is an extracellular glycosaminoglycan that plays a role in cell adhesion and migration. LYVE1 functions in lympathic hyaluronan transport and is involved in tumor metastasis. Recombinant human LYVE1 was expressed in and purified by conventional chromatography techniques. The normal adult human choroid is endowed with a significant number of LYVE-1 positive macrophages. LYVE-1 is expressed in a reticulum cell neoplasm in an axillary lymph node. This reticulum cell sarcoma is a lymphatic sinus lining cell sarcoma which might represent another subtype of reticulum cell sarcomas.LYVE-1 immunohistochemistry is a functional method for detecting lymphatics invaded by cancer cells, and detailed examination of the submucosa around the tumor is important for predicting LN metastasis.
 Product Categories/Family for LYVE-1 recombinant protein    PROTEIN KINASES; Enzymes; LYVE1
NCBI/Uniprot data below describe general gene information for LYVE-1. It may not necessarily be applicable to this product.
 NCBI GI #    40549451
 NCBI GeneID    10894
 NCBI Accession #    NP_006682.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006691.3 [Other Products]
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 UniProt Primary Accession #    Q9Y5Y7 [Other Products]
 UniProt Secondary Accession #    Q8TC18; Q9UNF4 [Other Products]
 UniProt Related Accession #    Q9Y5Y7 [Other Products]
 Molecular Weight    35,213 Da
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 NCBI Official Full Name    lymphatic vessel endothelial hyaluronic acid receptor 1
 NCBI Official Synonym Full Names    lymphatic vessel endothelial hyaluronan receptor 1
 NCBI Official Symbol    LYVE1 [Similar Products]
 NCBI Official Synonym Symbols   
HAR; XLKD1; LYVE-1; CRSBP-1
[Similar Products]
 NCBI Protein Information    lymphatic vessel endothelial hyaluronic acid receptor 1; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1; extracellular link domain containing 1; extracellular link domain-containing 1; extracellular link domain-containing protein 1
 UniProt Protein Name    Lymphatic vessel endothelial hyaluronic acid receptor 1
 UniProt Synonym Protein Names   
Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor
 Protein Family    Lymphatic vessel endothelial hyaluronic acid receptor
 UniProt Gene Name    LYVE1 [Similar Products]
 UniProt Synonym Gene Names    CRSBP1; HAR; XLKD1; LYVE-1; CRSBP-1 [Similar Products]
 UniProt Entry Name    LYVE1_HUMAN
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 NCBI Summary for LYVE-1    This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LYVE-1    XLKD1: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: transmembrane receptor activity; hyaluronic acid binding; receptor activity

Biological Process: anatomical structure morphogenesis; glycosaminoglycan metabolic process; transport; cell-matrix adhesion; carbohydrate metabolic process; response to wounding; pathogenesis; signal transduction; cell motility; hyaluronan metabolic process; hyaluronan catabolic process
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 Research Articles on LYVE-1    1. Data indicate that detection of lymphatic vascular invasion (LVI) can be optimized by specific D2-40 or LYVE-1 staining.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LYVE-1 recombinant proteinPathways associated with LYVE-1 recombinant protein
 Reference Product  PubMed Publications
 VEGFC recombinant protein  >59 publications with LYVE-1 and VEGFC
 CD44 recombinant protein  >19 publications with LYVE-1 and CD44
 STAB2 recombinant protein  >3 publications with LYVE-1 and STAB2
 IGFBP3 recombinant protein  >2 publications with LYVE-1 and IGFBP3
 ATM recombinant protein  >1 publications with LYVE-1 and ATM
 Products by Pathway  Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
 Defective EXT2 Causes Exostoses 2 Pathway antibodies  Defective EXT2 Causes Exostoses 2 Pathway Diagram
 Defective PAPSS2 Causes SEMD-PA Pathway antibodies  Defective PAPSS2 Causes SEMD-PA Pathway Diagram
Diseases associated with LYVE-1 recombinant proteinOrgans/Tissues associated with LYVE-1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >21 publications with LYVE-1 and Inflammation
 Disease Models, Animal Antibodies  >14 publications with LYVE-1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >13 publications with LYVE-1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >11 publications with LYVE-1 and Lung Diseases
 Necrosis Antibodies  >11 publications with LYVE-1 and Necrosis
 Liver Neoplasms Antibodies  >10 publications with LYVE-1 and Liver Neoplasms
 Edema Antibodies  >9 publications with LYVE-1 and Edema
 Liver Diseases Antibodies  >9 publications with LYVE-1 and Liver Diseases
 Fibrosis Antibodies  >5 publications with LYVE-1 and Fibrosis
 Carcinoma, Hepatocellular Antibodies  >5 publications with LYVE-1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >181 publications with LYVE-1 and Vascular
 Eye Antibodies  >23 publications with LYVE-1 and Eye
 Lung Antibodies  >21 publications with LYVE-1 and Lung
 Embryonic Tissue Antibodies  >16 publications with LYVE-1 and Embryonic Tissue
 Muscle Antibodies  >15 publications with LYVE-1 and Muscle
 Liver Antibodies  >15 publications with LYVE-1 and Liver
 Bone Antibodies  >11 publications with LYVE-1 and Bone
 Stomach Antibodies  >10 publications with LYVE-1 and Stomach
 Connective Tissue Antibodies  >9 publications with LYVE-1 and Connective Tissue
 Heart Antibodies  >7 publications with LYVE-1 and Heart
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