NP_002986.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,517 Da
NCBI Official Full Name
lymphotactin
UniProt Protein Name
Lymphotactin
UniProt Synonym Protein Names
ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1
UniProt Synonym Gene Names
UniProt Entry Name
XCL1_HUMAN
NCBI Summary for Lymphotactin
This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
UniProt Comments for Lymphotactin
XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1q23
Cellular Component: extracellular space; extracellular region
Molecular Function: protein homodimerization activity; chemokine activity; chemokine receptor binding
Biological Process: neutrophil chemotaxis; negative regulation of T-helper 1 type immune response; positive regulation of T cell mediated cytotoxicity; negative regulation of transcription factor activity; response to virus; positive regulation of T cell cytokine production; positive regulation of leukocyte chemotaxis; negative regulation of T cell cytokine production; signal transduction; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production; cell-cell signaling; negative regulation of interferon-gamma production; release of sequestered calcium ion into cytosol; regulation of inflammatory response; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transcription, DNA-dependent
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Products associated with Lymphotactin recombinant protein
Pathways associated with Lymphotactin recombinant protein
Diseases associated with Lymphotactin recombinant protein
Organs/Tissues associated with Lymphotactin recombinant protein
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