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XCL1 recombinant protein :: Lymphotactin/XCL1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203317
SDS-PAGE
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
0.25 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lymphotactin/XCL1, Recombinant Protein

 Also Known As   

Lymphotactin/XCL1, 22-114aa, Human, His-tag, Recombinant, E Coli

 Product Synonym Names    XCL1; ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1; SCYC1; Chemokine (C motif) ligand 1; Lymphotactin/XCL1; Chemokine (C motif) ligand 1 C motif chemokine 1; SCM 1 alpha; SCM1; SCYC1; Chemokine C Motif Ligand 1; Small inducible cytokine C1; Small Inducible Cytokine Subfamily C Member 1; XC chemokine ligand 1; XCL1.
 Product Gene Name   

XCL1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MVGSEVSDKR TCVSLTTQRL PVSRIKTYTI TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT GTQQSTNTAV TLTG
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol 2 mM DTT, 0.2 M NaCl.
 Concentration    0.25 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of XCL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for XCL1 recombinant protein

   Lymphotactin, also known as XCL1, is member of gamma or C subfamily of chemokines. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. The expression of lymphotactin is restricted to activated T cells such as activated CD8+ T cells and other calss IMHC restricted T cells. Since lymphotactin is produced by lymphocytes and acts on lymphocytes, it is speculated that it is a messenger in T cell chemoattraction. Recombinant human XCL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
 Product Categories/Family for XCL1 recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for XCL1 recombinant protein   

SDS-PAGE

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 SDS-PAGE of XCL1 recombinant protein    XCL1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for XCL1. It may not necessarily be applicable to this product.
 NCBI GI #    4506853
 NCBI GeneID    6375
 NCBI Accession #    NP_002986 [Other Products]
 NCBI GenBank Nucleotide #    NM_002995.2 [Other Products]
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 UniProt Secondary Accession #    Q52MA8 [Other Products]
 UniProt Related Accession #    P47992 [Other Products]
 Molecular Weight    12.5 kDa (114aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher) [Similar Products]
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 NCBI Official Full Name    lymphotactin
 NCBI Official Synonym Full Names    chemokine (C motif) ligand 1
 NCBI Official Symbol    XCL1 [Similar Products]
 NCBI Official Synonym Symbols   
LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
[Similar Products]
 NCBI Protein Information    lymphotactin; SCM-1-alpha; XC chemokine ligand 1; c motif chemokine 1; cytokine SCM-1; lymphotaxin; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); small-inducible cytokine C1
 UniProt Protein Name    Lymphotactin
 UniProt Synonym Protein Names   
ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1
 Protein Family    Lymphotactin
 UniProt Gene Name    XCL1 [Similar Products]
 UniProt Synonym Gene Names    LTN; SCYC1 [Similar Products]
 UniProt Entry Name    XCL1_HUMAN
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 NCBI Summary for XCL1    This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
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 UniProt Comments for XCL1    XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: extracellular space; extracellular region

Molecular Function: protein homodimerization activity; chemokine activity; chemokine receptor binding

Biological Process: neutrophil chemotaxis; negative regulation of T-helper 1 type immune response; positive regulation of T cell mediated cytotoxicity; negative regulation of transcription factor activity; response to virus; positive regulation of T cell cytokine production; positive regulation of leukocyte chemotaxis; negative regulation of T cell cytokine production; signal transduction; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production; cell-cell signaling; release of sequestered calcium ion into cytosol; negative regulation of interferon-gamma production; regulation of inflammatory response; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transcription, DNA-dependent
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Product References and Citations for XCL1 recombinant protein

   Yoshida T., et al. (1996). FEBS Lett. 395(1):82-8.
Kennedy J., et al. (1995). J Immunol. 155(1):203-9.
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 Research Articles on XCL1    1. XCL1 displays antimicrobial activity against E. coli and S. aureus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with XCL1 recombinant proteinPathways associated with XCL1 recombinant protein
 Reference Product  PubMed Publications
 CD4 recombinant protein  >46 publications with XCL1 and CD4
 XCR1 recombinant protein  >32 publications with XCL1 and XCR1
 CXCR3 recombinant protein  >10 publications with XCL1 and CXCR3
 CCR5 recombinant protein  >8 publications with XCL1 and CCR5
 CCR1 recombinant protein  >5 publications with XCL1 and CCR1
 CX3CR1 recombinant protein  >4 publications with XCL1 and CX3CR1
 CCR2 recombinant protein  >3 publications with XCL1 and CCR2
 CCR3 recombinant protein  >2 publications with XCL1 and CCR3
 CCR7 recombinant protein  >2 publications with XCL1 and CCR7
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
Diseases associated with XCL1 recombinant proteinOrgans/Tissues associated with XCL1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >27 publications with XCL1 and Inflammation
 Necrosis Antibodies  >17 publications with XCL1 and Necrosis
 Disease Models, Animal Antibodies  >16 publications with XCL1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >14 publications with XCL1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >12 publications with XCL1 and Lung Diseases
 Nervous System Diseases Antibodies  >6 publications with XCL1 and Nervous System Diseases
 Colonic Neoplasms Antibodies  >4 publications with XCL1 and Colonic Neoplasms
 Eye Diseases Antibodies  >4 publications with XCL1 and Eye Diseases
 Kidney Diseases Antibodies  >3 publications with XCL1 and Kidney Diseases
 Lymphoma Antibodies  >3 publications with XCL1 and Lymphoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >138 publications with XCL1 and Blood
 Lung Antibodies  >16 publications with XCL1 and Lung
 Lymph Node Antibodies  >8 publications with XCL1 and Lymph Node
 Kidney Antibodies  >7 publications with XCL1 and Kidney
 Prostate Antibodies  >2 publications with XCL1 and Prostate
 Uterus Antibodies  >1 publications with XCL1 and Uterus
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