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LYZ recombinant protein :: Lysozyme Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS172024 LYZ recombinant protein
Unit / Price
100 mg  /  $130 +1 FREE 8GB USB
1 g  /  $230 +1 FREE 8GB USB
5 g  /  $480 +1 FREE 8GB USB
100 g  /  $2,410 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lysozyme (LYZ), Recombinant Protein

 Also Known As   

Recombinant Human Lysozyme

 Product Synonym Names    Lysozyme
 Product Gene Name   

LYZ recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 153450
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 Purity/Purification    > 90% (SDS-PAGE)
 Form/Format    Lyophilized
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 Source    Rice (Oryza sativa)
 EC Number    3.2.1.17
 Specific Activity    >=10,000 U/mg protein
 Solubility    Clear solution at 10 mg/mL PBS
 Recertification    2 years
 Protein    >= 0.75 mg protein/mg solid (Nitrogen Analyzer)
 Moisture Content    <=10%
 Activity    >100,000 U/mg protein
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 Preparation and Storage    2-8 degree C
 Other Notes    Small volumes of LYZ recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for LYZ recombinant protein

   MyBioSource sells research and bulk quantities of Recombinant Human Lysozyme, expressed in rice and purified from an animal free system.

Custom preparations, technical support, bulk quantities and aliquoting available.

Lysozyme lyses the peptidoglycan polymer typically found in most bacterial cell walls. Recombinant Lysozyme has identical amino acid sequences as the native Lysozyme. In lysing bacterial cells, recombinant Lysozyme is added to the cell extraction buffer at a range of 0.05 to 0.5 mg/mL (7,000 to 70,000 U/mL).

Typically, the extraction buffer contains 100mM tris HCL, 2mM EDTA, 0.05% trion I-100, pH 8.0. The cell paste is suspended in extraction buffer and incubated for at least 15 minutes at room temperature. Alternatively, Triton X-100 at 1% and PMSF at 1mM can be added separately and the lysis solution is further incubated for at least 15 minutes at 37C. The lysed cell suspension is clarified by centrifugation at 20,000 g for at least 15 minutes. The extraction conditions and concentration of recombinant lyosozyme needed for optiomal cell lysis and protein recovery depends on various factors.

Not only does lysozyme have very important clinical implications, but it is also a useful tool in molecular biology. The ability of lysozyme to break down bacterial cell walls (cell lysis) is utilized by molecular biologists. Cell lysis is necessary to extract recombinant proteins or DNA from bacterial cells. Human lysozyme is preferred to chicken lysozyme because it is up to four times more active. Also, the activity of chicken lysozyme has high lot-to-lot variation. Many recombinant protein production systems prefer an animal-free lysozyme to avoid the risk of infectious disease transmission.
 Product Categories/Family for LYZ recombinant protein    Recombinant; Proteins; Antigens; Standards/controls; Lysozyme
NCBI/Uniprot data below describe general gene information for LYZ. It may not necessarily be applicable to this product.
 NCBI GI #    307142
 NCBI GeneID    4069
 NCBI Accession #    AAA59536.1 [Other Products]
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 UniProt Secondary Accession #    P00695; Q13170; Q9UCF8 [Other Products]
 UniProt Related Accession #    P61626 [Other Products]
 Molecular Weight    16,537 Da [Similar Products]
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 NCBI Official Full Name    lysozyme (EC 3.2.1.17)
 NCBI Official Synonym Full Names    lysozyme
 NCBI Official Symbol    LYZ [Similar Products]
 NCBI Official Synonym Symbols   
LZM
[Similar Products]
 NCBI Protein Information    lysozyme C; c-type lysozyme; 1,4-beta-N-acetylmuramidase C
 UniProt Protein Name    Lysozyme C
 UniProt Synonym Protein Names   
1,4-beta-N-acetylmuramidase C
 Protein Family    Lysozyme
 UniProt Gene Name    LYZ [Similar Products]
 UniProt Synonym Gene Names    LZM [Similar Products]
 UniProt Entry Name    LYSC_HUMAN
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 NCBI Summary for LYZ    This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
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 UniProt Comments for LYZ    LYZ: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Defects in LYZ are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Belongs to the glycosyl hydrolase 22 family.

Protein type: Secreted, signal peptide; Endoplasmic reticulum; EC 3.2.1.17; Vesicle; Secreted; Hydrolase

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular space; extracellular region

Molecular Function: identical protein binding; lysozyme activity

Biological Process: retinal homeostasis; metabolic process; cytolysis; defense response to bacterium; inflammatory response

Disease: Amyloidosis, Familial Visceral
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 Research Articles on LYZ    1. Both mRNA and protein levels of lysozyme were significantly higher in patients with biofilm associated chronic rhinosinusitis (CRS) than those with CRS and no biofilm and controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LYZ recombinant proteinPathways associated with LYZ recombinant protein
 Reference Product  PubMed Publications
 LTF recombinant protein  >3 publications with LYZ and LTF
 GSN recombinant protein  >1 publications with LYZ and GSN
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Salivary Secretion Pathway antibodies  Salivary Secretion Pathway Diagram
 Salivary Secretion Pathway antibodies  Salivary Secretion Pathway Diagram
Diseases associated with LYZ recombinant proteinOrgans/Tissues associated with LYZ recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >11 publications with LYZ and Inflammation
 Cardiovascular Diseases Antibodies  >7 publications with LYZ and Cardiovascular Diseases
 Necrosis Antibodies  >7 publications with LYZ and Necrosis
 Disease Models, Animal Antibodies  >5 publications with LYZ and Disease Models, Animal
 Heart Diseases Antibodies  >2 publications with LYZ and Heart Diseases
 Neoplasms, Experimental Antibodies  >2 publications with LYZ and Neoplasms, Experimental
 Kidney Diseases Antibodies  >2 publications with LYZ and Kidney Diseases
 Fibrosis Antibodies  >2 publications with LYZ and Fibrosis
 Lung Diseases Antibodies  >2 publications with LYZ and Lung Diseases
 Hypertension Antibodies  >2 publications with LYZ and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >29 publications with LYZ and Blood
 Intestine Antibodies  >8 publications with LYZ and Intestine
 Bone Antibodies  >7 publications with LYZ and Bone
 Liver Antibodies  >7 publications with LYZ and Liver
 Heart Antibodies  >7 publications with LYZ and Heart
 Vascular Antibodies  >7 publications with LYZ and Vascular
 Kidney Antibodies  >6 publications with LYZ and Kidney
 Lymph Node Antibodies  >4 publications with LYZ and Lymph Node
 Muscle Antibodies  >4 publications with LYZ and Muscle
 Stomach Antibodies  >3 publications with LYZ and Stomach
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