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LOXL1 recombinant protein :: Lysyl Oxidase Like Protein 1 (LOXL1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2010841 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) LOXL1 recombinant protein
Unit / Price
0.01 mg  /  $185 +1 FREE 8GB USB
0.05 mg  /  $380 +1 FREE 8GB USB
0.1 mg  /  $585 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lysyl Oxidase Like Protein 1 (LOXL1), Recombinant Protein

 Also Known As   

Recombinant Lysyl Oxidase Like Protein 1 (LOXL1)

 Product Gene Name   

LOXL1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF-LPDLVP D PNYVQASTYV QRAHLYSLRC AAEEKCLAST AYAPEATDYD VRVLLRFPQR VKNQGTADFL PNRPRHTWEW HSCHQHYHSM DEFSHYDLLD AATGKKVAEG HKASFCLEDS TCDFGNLKRY ACTSHTQGLS PGCYDTYNAD IDCQWIDITD VQPGNYILKV HVNPKYIVLE SDFTNNVVRC NIHYTGRYVS ATNCKIVQS
 Chromosome Location    Chromosome: 15; NC_000015.9 (74218789..74244478). Location: 15q22
 OMIM    153456
 3D Structure    ModBase 3D Structure for Q08397
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Leu369~Ser574 (Accession # Q08397) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of LOXL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for LOXL1 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for LOXL1 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for LOXL1. It may not necessarily be applicable to this product.
 NCBI GI #    67782346
 NCBI GeneID    4016
 NCBI Accession #    NP_005567.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005576.2 [Other Products]
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 UniProt Primary Accession #    Q08397 [Other Products]
 UniProt Secondary Accession #    Q6NUL3; Q96BW7 [Other Products]
 UniProt Related Accession #    Q08397 [Other Products]
 Molecular Weight    25.0kDa
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 NCBI Official Full Name    lysyl oxidase homolog 1 preproprotein
 NCBI Official Synonym Full Names    lysyl oxidase-like 1
 NCBI Official Symbol    LOXL1 [Similar Products]
 NCBI Official Synonym Symbols   
LOL; LOXL
[Similar Products]
 NCBI Protein Information    lysyl oxidase homolog 1; lysyl oxidase-like protein 1
 UniProt Protein Name    Lysyl oxidase homolog 1
 UniProt Synonym Protein Names   
Lysyl oxidase-like protein 1
 Protein Family    Lysyl oxidase
 UniProt Gene Name    LOXL1 [Similar Products]
 UniProt Synonym Gene Names    LOXL; LOL [Similar Products]
 UniProt Entry Name    LOXL1_HUMAN
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 NCBI Summary for LOXL1    This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LOXL1    LOXL1: Active on elastin and collagen substrates. Genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome (XFS); also called exfoliation glaucoma (XFG). XFS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations. Belongs to the lysyl oxidase family.

Protein type: Oxidoreductase; Secreted; EC 1.4.3.-; Secreted, signal peptide; Extracellular matrix

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: extracellular matrix; extracellular space; extracellular region; acrosome; basement membrane

Molecular Function: copper ion binding; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process: extracellular matrix organization and biogenesis; response to lipopolysaccharide; protein amino acid deamination

Disease: Exfoliation Syndrome
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 Research Articles on LOXL1    1. LOXL1 is more abundant in the deposits in the iris region and, alternatively APOE is concentrated in the PEX material accumulated in the pupillary area of the anterior lens capsule.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LOXL1 recombinant proteinPathways associated with LOXL1 recombinant protein
 Reference Product  PubMed Publications
 FBLN5 recombinant protein  >10 publications with LOXL1 and FBLN5
 FBN1 recombinant protein  >2 publications with LOXL1 and FBN1
 ELN recombinant protein  >2 publications with LOXL1 and ELN
 COL5A1 recombinant protein  >1 publications with LOXL1 and COL5A1
 Products by Pathway  Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Crosslinking Of Collagen Fibrils Pathway antibodies  Crosslinking Of Collagen Fibrils Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with LOXL1 recombinant proteinOrgans/Tissues associated with LOXL1 recombinant protein
 Disease Name  Pubmed Publications
 Exfoliation Syndrome Antibodies  >78 publications with LOXL1 and Exfoliation Syndrome
 Cardiovascular Diseases Antibodies  >15 publications with LOXL1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >10 publications with LOXL1 and Disease Models, Animal
 Fibrosis Antibodies  >6 publications with LOXL1 and Fibrosis
 Nervous System Diseases Antibodies  >5 publications with LOXL1 and Nervous System Diseases
 Inflammation Antibodies  >4 publications with LOXL1 and Inflammation
 Hypertension Antibodies  >4 publications with LOXL1 and Hypertension
 Heart Diseases Antibodies  >3 publications with LOXL1 and Heart Diseases
 Urinary Bladder Neoplasms Antibodies  >3 publications with LOXL1 and Urinary Bladder Neoplasms
 Kidney Diseases Antibodies  >2 publications with LOXL1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >54 publications with LOXL1 and Eye
 Connective Tissue Antibodies  >25 publications with LOXL1 and Connective Tissue
 Vascular Antibodies  >19 publications with LOXL1 and Vascular
 Muscle Antibodies  >13 publications with LOXL1 and Muscle
 Skin Antibodies  >11 publications with LOXL1 and Skin
 Bone Antibodies  >11 publications with LOXL1 and Bone
 Nerve Antibodies  >9 publications with LOXL1 and Nerve
 Lung Antibodies  >6 publications with LOXL1 and Lung
 Kidney Antibodies  >6 publications with LOXL1 and Kidney
 Bladder Antibodies  >6 publications with LOXL1 and Bladder
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