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Loxl2 recombinant protein :: Lysyl oxidase homolog 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS718282
SDS-PAGE
Unit / Price
0.01 mg (Yeast)  /  $195 +1 FREE 8GB USB
0.01 mg (E-Coli)  /  $230 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $255 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $310 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $415 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $515 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $660 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $830 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,090 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,090 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,325 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,575 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,680 +2 FREE 8GB USB
1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,730 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,365 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,395 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $3,135 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lysyl oxidase homolog 2 (Loxl2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Lysyl oxidase homolog 2

 Product Synonym Names    Lysyl oxidase-like protein 2
 Product Gene Name   

Loxl2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS718282 COA    COA PDF
 Sequence Positions    26-776. Full length of mature protein;
 Sequence    QYEGWPYQLQ YPEYFQQPAP EHHQRQVPSD VVKIQVRLAG QKRKHNEGRV EVYYEGQWGT VCDDDFSIHA AHVVCRQVGY VEAKSWAASS SYGPGEGPIW LDNIYCTGKE STLASCSSNG WGVTDCKHTE DVGVVCSEKR IPGFKFDNSL INQIESLNIQ VEDIRIRPIL SAFRHRKPVT EGYVEVKEGK AWKQICNKHW TAKNSHVVCG MFGFPAEKTY NPKAYKTFAS RRKLRYWKFS MNCTGTEAHI SSCKLGPSVT RDPVKNATCE NGQPAVVSCV PSQIFSPDGP SRFRKAYKPE QPLVRLRGGA QVGEGRVEVL KNGEWGTICD DKWDLVSASV VCRELGFGTA KEAITGSRLG QGIGPIHLNE VQCTGTEKSI IDCKFNTESQ GCNHEEDAGV RCNIPIMGFQ KKVRLNGGRN PYEGRVEVLT ERNGSLVWGT VCGQNWGIVE AMVVCRQLGL GFASNAFQET WYWHGNIFAN NVVMSGVKCS GTELSLAHCR HDEEVACPEG GVRFGAGVAC SETAPDLVLN AEIVQQTAYL EDRPMSLLQC AMEENCLSAS AVHTDPTRGH RRLLRFSSQI HNNGQSDFRP KNGRHAWIWH DCHRHYHSME VFTYYDLLSL NGTKVAEGHK ASFCLEDTEC EGDIQKSYEC ANFGEQGITM GCWDMYRHDI DCQWIDITDV PPGDYLFQVV INPNYEVPES DFSNNIMKCR SRYDGYRIWM YNCHVGGAFS EETEQKFEHF SGLLNNQLSV Q
 3D Structure    ModBase 3D Structure for P58022
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Loxl2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Loxl2 recombinant protein

   Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (T) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. 1 Publication
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 SDS-PAGE of Loxl2 recombinant protein    Loxl2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Loxl2. It may not necessarily be applicable to this product.
 NCBI GI #    225579028
 NCBI GeneID    94352
 NCBI Accession #    NP_201582.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_033325.2 [Other Products]
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 UniProt Primary Accession #    P58022 [Other Products]
 UniProt Secondary Accession #    Q8BRE6; Q8BS86; Q8C4K0; Q9JJ39 [Other Products]
 UniProt Related Accession #    P58022 [Other Products]
 Molecular Weight    88.48kD
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 NCBI Official Full Name    lysyl oxidase homolog 2
 NCBI Official Synonym Full Names    lysyl oxidase-like 2
 NCBI Official Symbol    Loxl2 [Similar Products]
 NCBI Official Synonym Symbols   
1110004B06Rik; 4930526G11Rik; 9430067E15Rik
[Similar Products]
 NCBI Protein Information    lysyl oxidase homolog 2
 UniProt Protein Name    Lysyl oxidase homolog 2
 UniProt Synonym Protein Names   
Lysyl oxidase-like protein 2
 Protein Family    Lysyl oxidase
 UniProt Gene Name    Loxl2 [Similar Products]
 UniProt Entry Name    LOXL2_MOUSE
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 UniProt Comments for Loxl2    LOXL2: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. Belongs to the lysyl oxidase family.

Protein type: Secreted; Cell adhesion; Oxidoreductase; EC 1.4.3.13; Secreted, signal peptide

Cellular Component: basement membrane; chromosome; extracellular region; extracellular space; membrane; nucleoplasm; nucleus; proteinaceous extracellular matrix

Molecular Function: chromatin binding; copper ion binding; metal ion binding; methylated histone residue binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; protein-lysine 6-oxidase activity; scavenger receptor activity; transcription corepressor activity

Biological Process: chromatin modification; collagen fibril organization; endothelial cell migration; endothelial cell proliferation; epithelial to mesenchymal transition; histone modification; negative regulation of transcription, DNA-dependent; positive regulation of chondrocyte differentiation; protein amino acid deamination; protein modification process; regulation of transcription, DNA-dependent; response to copper ion; response to hypoxia; sprouting angiogenesis; transcription, DNA-dependent
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 Research Articles on Loxl2    1. LOX and LOXL2 may play an important role in the pathogenesis of AMD. Targeting LOXL2 could have a broader efficacy than targeting LOX, by reducing angiogenesis and inflammation, as well as fibrosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Loxl2 recombinant proteinDiseases associated with Loxl2 recombinant protein
 Reference Product  PubMed Publications
 Col1a1 recombinant protein  >6 publications with Loxl2 and Col1a1
 Snai1 recombinant protein  >3 publications with Loxl2 and Snai1
 Cdh1 recombinant protein  >2 publications with Loxl2 and Cdh1
 Col5a1 recombinant protein  >1 publications with Loxl2 and Col5a1
 Egfl7 recombinant protein  >1 publications with Loxl2 and Egfl7
 Ccnd1 recombinant protein  >1 publications with Loxl2 and Ccnd1
 Ramp3 recombinant protein  >1 publications with Loxl2 and Ramp3
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >22 publications with Loxl2 and Fibrosis
 Breast Neoplasms Antibodies  >21 publications with Loxl2 and Breast Neoplasms
 Neoplasm Invasiveness Antibodies  >17 publications with Loxl2 and Neoplasm Invasiveness
 Lung Diseases Antibodies  >15 publications with Loxl2 and Lung Diseases
 Disease Models, Animal Antibodies  >11 publications with Loxl2 and Disease Models, Animal
 Lung Neoplasms Antibodies  >11 publications with Loxl2 and Lung Neoplasms
 Inflammation Antibodies  >9 publications with Loxl2 and Inflammation
 Neoplasms, Experimental Antibodies  >8 publications with Loxl2 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >7 publications with Loxl2 and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >6 publications with Loxl2 and Cardiovascular Diseases
Organs/Tissues associated with Loxl2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >19 publications with Loxl2 and Lung
 Bone Antibodies  >15 publications with Loxl2 and Bone
 Eye Antibodies  >12 publications with Loxl2 and Eye
 Connective Tissue Antibodies  >11 publications with Loxl2 and Connective Tissue
 Heart Antibodies  >8 publications with Loxl2 and Heart
 Bone Marrow Antibodies  >7 publications with Loxl2 and Bone Marrow
 Kidney Antibodies  >6 publications with Loxl2 and Kidney
 Embryonic Tissue Antibodies  >5 publications with Loxl2 and Embryonic Tissue
 Prostate Antibodies  >3 publications with Loxl2 and Prostate
 Mammary Gland Antibodies  >3 publications with Loxl2 and Mammary Gland
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