Q8JZQ0.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
18.1; 36.2
NCBI Official Full Name
Macrophage colony-stimulating factor 1
NCBI Official Synonym Full Names
colony stimulating factor 1
NCBI Protein Information
macrophage colony-stimulating factor 1
UniProt Protein Name
Macrophage colony-stimulating factor 1
UniProt Synonym Gene Names
UniProt Entry Name
CSF1_RAT
NCBI Summary for M-CSF
plays a role in macrophage formation; involved in osteoclastogenesis and endochondral ossification [RGD, Feb 2006]
UniProt Comments for M-CSF
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance ().
Research Articles on M-CSF
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Disclaimer
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Products associated with M-CSF active protein
Pathways associated with M-CSF active protein
Organs/Tissues associated with M-CSF active protein
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