NP_001107001.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36.4 kDa
NCBI Official Full Name
macrophage colony-stimulating factor 1 isoform 2
NCBI Official Synonym Full Names
colony stimulating factor 1 (macrophage)
NCBI Protein Information
macrophage colony-stimulating factor 1; osteopetrosis
UniProt Protein Name
Macrophage colony-stimulating factor 1
UniProt Synonym Gene Names
UniProt Entry Name
CSF1_MOUSE
UniProt Comments for M-CSF
Function: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Subunit structure: Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R. Ref.14
Subcellular location: Cell membrane; Single-pass type I membrane protein
By similarity. Processed macrophage colony-stimulating factor 1: Secreted › extracellular space
By similarity.
Post-translational modification: N-glycosylated. The predominant soluble form is a chondroitin sulfate-containing proteoglycan.
Involvement in disease: A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling. Ref.13
Caution: The sequence reported in Ref.3 was thought to originate from rat, but was later shown (Ref.10 and Ref.11) to be derived from mouse.
Research Articles on M-CSF
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Pathways associated with M-CSF active protein
Diseases associated with M-CSF active protein
Organs/Tissues associated with M-CSF active protein
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