NP_002349.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,335 Da
NCBI Official Full Name
mitotic spindle assembly checkpoint protein MAD2A
NCBI Official Synonym Full Names
MAD2 mitotic arrest deficient-like 1 (yeast)
NCBI Official Synonym Symbols
NCBI Protein Information
mitotic spindle assembly checkpoint protein MAD2A; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1
UniProt Protein Name
Mitotic spindle assembly checkpoint protein MAD2A
UniProt Synonym Protein Names
Mitotic arrest deficient 2-like protein 1; MAD2-like protein 1
UniProt Synonym Gene Names
UniProt Entry Name
MD2L1_HUMAN
NCBI Summary for MAD2L1
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]
UniProt Comments for MAD2L1
MAD2L1: required for the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. Inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. Interacts with Cdc20, MAD2L1BP and with ADAM17/TACE
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 4q27
Cellular Component: kinetochore; spindle pole; perinuclear region of cytoplasm; nuclear pore; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; protein homodimerization activity
Biological Process: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitotic sister chromatid segregation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle checkpoint; mitotic cell cycle spindle assembly checkpoint; negative regulation of mitotic cell cycle; mitotic cell cycle; negative regulation of protein catabolic process; negative regulation of apoptosis
Research Articles on MAD2L1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with MAD2L1 recombinant protein
Pathways associated with MAD2L1 recombinant protein
Diseases associated with MAD2L1 recombinant protein
Organs/Tissues associated with MAD2L1 recombinant protein
|