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MAGOH recombinant protein

Scan QR to view Datasheet Catalog #    MBS203529
SDS-Page
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAGOH, Recombinant Protein

 Also Known As   

MAGOH, 1-146aa, Human, His tag, E Coli

 Product Synonym Names    Protein mago nashi homolog; MAGOH1; MAGOHA; Protein mago nashi homolog Mago nashi homolog proliferation associated (Drosophila); Mago nashi protein homolog.
 Product Gene Name   

MAGOH recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MESDFYLRYY VGHKGKFGHE FLEFEFRPDG KLRYANNSNY KNDVMIRKEA YVHKSVMEEL KRIIDDSEIT KEDDALWPPP DRVGRQELEI VIGDEHISFT TSKIGSLIDV NQSKDPEGLR VFYYLVQDLK CLVFSLIGLH FKIKPILEHH HHHH
 OMIM    AF035940 mRNA
 3D Structure    ModBase 3D Structure for P61326
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 2mM DTT, 0.1M NaCl, 20% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of MAGOH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MAGOH recombinant protein

   MAGOH, the human homolog of Drosophila mago nashi, is required for embryo development. MAGOH is ubiquitously expressed in adult tissues. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. Recombinant human MAGOH protein, fused to His-tag at C-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for MAGOH recombinant protein    Transcription & Translation
 Applications Tested/Suitable for MAGOH recombinant protein   

SDS-PAGE

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 SDS-Page of MAGOH recombinant protein    MAGOH recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for MAGOH. It may not necessarily be applicable to this product.
 NCBI GI #    4505087
 NCBI GeneID    4116
 NCBI Accession #    NP_002361 [Other Products]
 NCBI GenBank Nucleotide #    NM_002370.3 [Other Products]
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 UniProt Primary Accession #    P61326 [Other Products]
 UniProt Secondary Accession #    O35169; P50606; Q5SW69; B1ARP8; B2R5A2 [Other Products]
 UniProt Related Accession #    P61326 [Other Products]
 Molecular Weight    18.2 kDa (154aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    protein mago nashi homolog
 NCBI Official Synonym Full Names    mago homolog, exon junction complex core component
 NCBI Official Symbol    MAGOH [Similar Products]
 NCBI Official Synonym Symbols   
MAGOH1; MAGOHA
[Similar Products]
 NCBI Protein Information    protein mago nashi homolog
 UniProt Protein Name    Protein mago nashi homolog
 Protein Family    Protein mago nashi
 UniProt Gene Name    MAGOH [Similar Products]
 UniProt Synonym Gene Names    MAGOHA [Similar Products]
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 NCBI Summary for MAGOH    Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAGOH    Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.
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Product References and Citations for MAGOH recombinant protein

   Gehring NH., et al. (2009) Cell. 137 (3):536-48. ; Chamieh H., et al. (2008) Nat Struct Mol Biol. 15 (1):85-93.;
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 Research Articles on MAGOH    1. findings show 2 genes MAGOH and MAGOHB are expressed in mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA increases after LPS stimulation; both MAGOH proteins interact with other exon junction complex (EJC) components, incorporate into mRNA-bound EJCs and activate nonsense-mediated decay
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MAGOH recombinant proteinPathways associated with MAGOH recombinant protein
 Reference Product  PubMed Publications
 RBM8A recombinant protein  >32 publications with MAGOH and RBM8A
 EIF4A3 recombinant protein  >15 publications with MAGOH and EIF4A3
 CASC3 recombinant protein  >14 publications with MAGOH and CASC3
 RNPS1 recombinant protein  >11 publications with MAGOH and RNPS1
 UPF3B recombinant protein  >8 publications with MAGOH and UPF3B
 MAGOHB recombinant protein  >3 publications with MAGOH and MAGOHB
 UPF3A recombinant protein  >2 publications with MAGOH and UPF3A
 DDX39B recombinant protein  >1 publications with MAGOH and DDX39B
 WIBG recombinant protein  >1 publications with MAGOH and WIBG
 Products by Pathway  Pathway Diagram
 Cleavage Of Growing Transcript In The Termination Region Pathway antibodies  Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
 Exon Junction Complex (EJC) Pathway antibodies  Exon Junction Complex (EJC) Pathway Diagram
 Exon Junction Complex (EJC) Pathway antibodies  Exon Junction Complex (EJC) Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Nonsense Mediated Decay (NMD) Enhanced By The Exon Junction Complex (EJC) Pathway antibodies  Nonsense Mediated Decay (NMD) Enhanced By The Exon Junction Complex (EJC) Pathway Diagram
 Nonsense-Mediated Decay (NMD) Pathway antibodies  Nonsense-Mediated Decay (NMD) Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 RNA Polymerase II Transcription Pathway antibodies  RNA Polymerase II Transcription Pathway Diagram
 RNA Polymerase II Transcription Termination Pathway antibodies  RNA Polymerase II Transcription Termination Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
Diseases associated with MAGOH recombinant proteinOrgans/Tissues associated with MAGOH recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >3 publications with MAGOH and Breast Neoplasms
 Adenocarcinoma Antibodies  >2 publications with MAGOH and Adenocarcinoma
 Precancerous Conditions Antibodies  >1 publications with MAGOH and Precancerous Conditions
 Liver Diseases Antibodies  >1 publications with MAGOH and Liver Diseases
 Inflammation Antibodies  >1 publications with MAGOH and Inflammation
 Necrosis Antibodies  >1 publications with MAGOH and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with MAGOH and Brain
 Embryonic Tissue Antibodies  >3 publications with MAGOH and Embryonic Tissue
 Lung Antibodies  >2 publications with MAGOH and Lung
 Lymph Node Antibodies  >2 publications with MAGOH and Lymph Node
 Lymph Antibodies  >2 publications with MAGOH and Lymph
 Blood Antibodies  >2 publications with MAGOH and Blood
 Testis Antibodies  >2 publications with MAGOH and Testis
 Eye Antibodies  >1 publications with MAGOH and Eye
 Skin Antibodies  >1 publications with MAGOH and Skin
 Liver Antibodies  >1 publications with MAGOH and Liver
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