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MAPRE1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203939
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAPRE1, Recombinant Protein

★Popular Item★
 Also Known As   

MAPRE1, 1-268aa, Human, His tag, E Coli

 Product Synonym Names    Microtubule-associated protein RP/EB family member 1.; Microtubule-associated protein RP/EB family member 1.; EB1; MGC117374; MGC129946
 Product Gene Name   

MAPRE1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MAVNVYSTSV TSDNLSRHDM LAWINESLQL NLTKIEQLCS GAAYCQFMDM LFPGSIALKK VKFQAKLEHE YIQNFKILQA GFKRMGVDKI IPVDKLVKGK FQDNFEFVQW FKKFFDANYD GKDYDPVAAR QGQETAVAPS LVAPALNKPK KPLTSSSAAP QRPISTQRTA AAPKAGPGVV RKNPGVGNGD DEAAELMQQV NVLKLTVEDL EKERDFYFGK LRNIELICQE NEGENDPVLQ RIVDILYATD EGFVIPDEGG PQEEQEEY
 OMIM    U24166 mRNA
 3D Structure    ModBase 3D Structure for Q15691
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 2mM DTT, 0.1M NaCl.
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of MAPRE1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MAPRE1 recombinant protein

   MAPRE1, also known as EB1, belongs to the intermediate/early gene family. This protein first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. It localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. MAPRE1 is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Recombinant human MAPRE1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for MAPRE1 recombinant protein    Cytoskeleton
 Applications Tested/Suitable for MAPRE1 recombinant protein   

SDS-PAGE

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 SDS-Page of MAPRE1 recombinant protein    MAPRE1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for MAPRE1. It may not necessarily be applicable to this product.
 NCBI GI #    6912494
 NCBI GeneID    22919
 NCBI Accession #    NP_036457 [Other Products]
 NCBI GenBank Nucleotide #    NM_012325.2 [Other Products]
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 UniProt Primary Accession #    Q15691 [Other Products]
 UniProt Secondary Accession #    Q3KQS8; B2R6I7; E1P5M8 [Other Products]
 UniProt Related Accession #    Q15691 [Other Products]
 Molecular Weight    32.2 kDa (288aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    microtubule-associated protein RP/EB family member 1
 NCBI Official Synonym Full Names    microtubule associated protein RP/EB family member 1
 NCBI Official Symbol    MAPRE1 [Similar Products]
 NCBI Official Synonym Symbols   
EB1
[Similar Products]
 NCBI Protein Information    microtubule-associated protein RP/EB family member 1
 UniProt Protein Name    Microtubule-associated protein RP/EB family member 1
 UniProt Synonym Protein Names   
APC-binding protein EB1; End-binding protein 1; EB1
 Protein Family    Microtubule-associated protein RP/EB family
 UniProt Gene Name    MAPRE1 [Similar Products]
 UniProt Synonym Gene Names    EB1 [Similar Products]
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 NCBI Summary for MAPRE1    The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAPRE1    Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:12388762). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). May play a role in cell migration ().
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Product References and Citations for MAPRE1 recombinant protein

   Zhang T., et al. (2009) J Cell Sci. 122 (Pt 9):1401-9. ; Tirnauer JS., et al. (2002) Mol Biol Cell. 13 (10):3614-26.;
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 Research Articles on MAPRE1    1. A novel EB1 acetylation site regulates the dynamic structure of microtubules.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MAPRE1 recombinant proteinPathways associated with MAPRE1 recombinant protein
 Reference Product  PubMed Publications
 KIF2C recombinant protein  >4 publications with MAPRE1 and KIF2C
 AURKB recombinant protein  >3 publications with MAPRE1 and AURKB
 CLASP1 recombinant protein  >2 publications with MAPRE1 and CLASP1
 CLASP2 recombinant protein  >1 publications with MAPRE1 and CLASP2
 MAD2L1 recombinant protein  >1 publications with MAPRE1 and MAD2L1
 CKAP5 recombinant protein  >1 publications with MAPRE1 and CKAP5
 Products by Pathway  Pathway Diagram
 AURKA Activation By TPX2 Pathway antibodies  AURKA Activation By TPX2 Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 Cilium Assembly Pathway antibodies  Cilium Assembly Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
Diseases associated with MAPRE1 recombinant proteinOrgans/Tissues associated with MAPRE1 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >11 publications with MAPRE1 and Carcinoma
 Adenocarcinoma Antibodies  >5 publications with MAPRE1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >4 publications with MAPRE1 and Breast Neoplasms
 Liver Diseases Antibodies  >3 publications with MAPRE1 and Liver Diseases
 Lung Neoplasms Antibodies  >3 publications with MAPRE1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with MAPRE1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with MAPRE1 and Liver Neoplasms
 Inflammation Antibodies  >2 publications with MAPRE1 and Inflammation
 Heart Diseases Antibodies  >2 publications with MAPRE1 and Heart Diseases
 Neoplasms, Experimental Antibodies  >1 publications with MAPRE1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with MAPRE1 and Blood
 Brain Antibodies  >9 publications with MAPRE1 and Brain
 Lung Antibodies  >7 publications with MAPRE1 and Lung
 Muscle Antibodies  >5 publications with MAPRE1 and Muscle
 Heart Antibodies  >5 publications with MAPRE1 and Heart
 Vascular Antibodies  >4 publications with MAPRE1 and Vascular
 Liver Antibodies  >4 publications with MAPRE1 and Liver
 Kidney Antibodies  >3 publications with MAPRE1 and Kidney
 Nerve Antibodies  >3 publications with MAPRE1 and Nerve
 Mouth Antibodies  >2 publications with MAPRE1 and Mouth
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